Investigation of the effect of metoclopramide on proliferation signal molecules in breast tissue.

Metoclopramide (MCP) is a drug that has been widely used in recent years due to its hyperprolactinaemia effect on mothers during breastfeeding. The aim of this study was to investigate the proliferative changes that MCP may cause in the maternal breast tissue. In this study, 18 Wistar albino young-adult breastfeeding mothers with their offspring were divided into three groups: control group, low-dose MCP-applied group and high-dose MCP-applied group. The experiment was carried out during the lactation period and at the end of 21 days. Prolactin, BrdU and Ki-67 breast tissue distributions were evaluated by immunohistochemistry, and tissue levels were evaluated biochemically by the ELISA method. According to ELISA and immunohistochemistry results in breast tissue, there was no significant difference between Ki-67 and BrdU results in all groups. Metoclopramide did not change the expression of proliferation molecules Ki-67 and BrdU in breast tissue. These results suggested that while metoclopramide increases breast proliferation, it does not have the risk of transforming the tissue into a tumour.

Breast self-examination training video with the sign language for deaf women: An interventional study.

OBJECTIVE: Breast self-examination is an important component for the early detection of breast cancer. The lack of knowledge of deaf women regarding breast examination and screenings may delay diagnosis of breast cancer. The objective of the study is to examine the effect of a video prepared with the sign language giving breast self-examination (BSE) skills to deaf women. METHODS: This study used a quantitative, quasi-experimental, comparison group research design. Participants were recruited from the Izmir Association for the Protection and Development of the Deaf, Izmir, Turkey. The research was conducted between March 2018 and March 2019. BSE training video was prepared by the researchers. One group (n = 30) watched a BSE training video with sign language. The other group (n = 30) watched a BSE training video without sign language. After the training video, the BSE Skill Assessment of all women were assessed on a female torso mannequin model using BSE Skill Assessment Form. RESULTS: The BSE skills of the women who watched the training video with sign language were significantly different from those who watched the training video without sign language (p < 0.05). CONCLUSION: The training video with the sign language prepared by the researchers can significantly improve the BSE skills of deaf women.

Effect of simulation training on students' childbirth skills and satisfaction in Turkey.

This study examined the effects of simulation training on student midwives' management skills for normal childbirth and their satisfaction. This study utilized a quantitative, quasi-experimental, comparison group research design. Students were placed into two groups according to the last digit of their school identity number (odd versus even), given by The Directorate of Student Affairs. Lots were drawn to decide which simulation model the odd and even numbers would represent. One group received simulation training for normal birth skills using a low-fidelity pelvic model (n = 37) while the other group used a high-fidelity computer-based mannequin (n = 38). After the skills training, each student midwife managed the second and third stages of a simulated normal childbirth. The skill checklists were used to evaluate the students' second and third stage labor midwifery skills. After the simulation activity, the Students' Satisfaction and Self-confidence Scale was used to measure their levels of satisfaction with the simulation activity and their self-confidence in learning. There were no significant differences between the groups in terms of childbirth management skills and satisfaction in learning (p > 0.05). Thus, both methods can be recommended for simulation training of student midwives.