G-CSF alone vs cyclophosphamide plus G-CSF in PBPC mobilization of patients with lymphoma: results depend on degree of previous pretreatment.

We performed a randomized study to compare 'G-CSF alone' (administered at dose of 10 mcg/kg/day) and 'cyclophosphamide plus G-CSF' (cyclophosphamide at dose of 4 g/m(2) and G-CSF at dose of 10 microg/kg/day), as PBPC mobilization schedules in 52 patients with NHL or HD. Randomization was stratified according to the amount of previous chemotherapy (< or =2 and >2 lines of previous chemotherapy). Mean CD34+ cell peak in P.B., mean 'Total CD34+ cells' harvested and percentage of patients successfully mobilized, in the group mobilized with 'G-CSF alone' vs the group mobilized with 'cyclophosphamide plus G-CSF', were: 35.3 x 10(6) vs 45.8 x 10(6)/l (P=0.3), 5.4 x 10(6) vs 6.8 x 10(6)/kg (P>0.9) and 50 vs 61% (P=0.4). No differences were observed in the stratum of less pretreated patients. However, in the stratum of patients who had previously received more than two lines of chemotherapy, CD34+cell peak (P=0.05) and percentage of successful mobilization (P=0.01) were higher when 'cyclophosphamide plus G-CSF' was used. Using logistic regression, both age and mobilization with 'G-CSF alone' were significantly associated with a low CD34+ cell peak in P.B. However, in the stratum of less pretreated patients, only age was significantly associated with this risk.

[Epidemiological research on dental caries incidence in a sample of the school-age population of Ragusa]. / Ricerche epidemiologiche sull'incidenza della carie dentale in un campione della popolazione scolastica di Ragusa.

The authors have conducted an epidemiologic research into a sample of 1500 schoolboys of Ragusa aged between a six and a twelve years old, to evaluate the incidence of dental caries. A small percentage of children practice correct oral cleanliness and know the importance of regular medical check-ups. The result is that, since childhood, a large incidence of dental caries is present whether in permanent teeth or in deciduous teeth, often precociously extracted and rarely treated with all the negative consequences that follow. Therefore it's necessary to intensify both information programs and dental prevention at a scholastic level in the intervention of a valid program of social and preventive medicine.

[Periodontal disease during pregnancy]. / Considerazioni cliniche sulle paradenziopatie nel corso della gravidanza.

The authors have reported three clinical cases of gingivitis during the pregnancy in the women. These gingivitis were noticed more frequently during the end of the second and the third quarter. The patients were educated to maintain a better oral hygiene and they were treated with scaling and root-planing to obtain the periodontal healing.