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1.
PLoS Biol ; 21(7): e3002204, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37478129

RESUMO

Research data is optimized when it can be freely accessed and reused. To maximize research equity, transparency, and reproducibility, policymakers should take concrete steps to ensure that research software is openly accessible and reusable.


Assuntos
Políticas , Software , Reprodutibilidade dos Testes
2.
J Adv Nurs ; 80(9): 3812-3824, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-38297432

RESUMO

AIM: Develop evidence-based recommendations for managers to support primary healthcare nurses to thrive at work. DESIGN: A mixed-methods sequential explanatory design. METHODS: National data were collected in 2020 via an e-survey based on a meta-analysis of antecedents of thriving from 213 primary healthcare nurses across New Zealand. Structural equation modelling analysis identified the key factors supporting primary healthcare nurses to thrive. This informed a second open-ended e-survey in 2022 of 19 nurses from one primary healthcare organization. The thematic analysis provided recommendations for improving management strategies to support thriving primary healthcare nurses. RESULTS: The vitality component of thriving significantly reduced burnout and intention to leave organization and profession. In contrast, the learning component of thriving had a significant positive effect on burnout. The key factors that support thriving at work are empowering leadership and perceived organizational supports (decreases burnout and intention to leave organization and profession through enhanced vitality). Recommendations for improving thriving were made in eight key areas: communication, effective management, professional development, scope of practice, autonomy, effective orientation, reward and work-life balance. CONCLUSIONS: Vitality is important in reducing burnout and turnover intentions. While learning was identified as increasing burnout, professional development and training for managers were identified as essential. Hence, the vitality dimension of the thriving at work construct should be studied at the dimension level, but more research is needed into the impact of learning on thriving over time. Primary healthcare nurses have identified that empowering leadership and perceived organizational support are critical factors in supporting them to thrive, and they provide specific recommendations for managers to improve these factors in the clinical setting. NO PATIENT OR PUBLIC CONTRIBUTION: This study collected data from Registered Nurses only. WHAT IS ALREADY KNOWN: A plethora of existing research focuses on resilience in nurses rather than thriving at work. Enabling employees to thrive at work contributes to improved well-being and sustainable organizational performance. WHAT THIS PAPER ADDS: Empowering leadership and perceived organizational support are the key factors that support primary healthcare nurses to thrive at work. The vitality dimension of the thriving at work construct should be studied at the dimension level, and further research is needed into the impact of learning on thriving over time. Primary healthcare nurses recommend that managers focus on improving communication, management efficiency, professional development, scope of practice, autonomy, orientation, reward and work-life balance.


Assuntos
Esgotamento Profissional , Satisfação no Emprego , Humanos , Esgotamento Profissional/psicologia , Esgotamento Profissional/prevenção & controle , Adulto , Feminino , Masculino , Nova Zelândia , Pessoa de Meia-Idade , Atenção Primária à Saúde , Inquéritos e Questionários , Reorganização de Recursos Humanos , Liderança , Enfermagem de Atenção Primária/psicologia
3.
J Clin Nurs ; 32(11-12): 2466-2480, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35579183

RESUMO

AIMS AND OBJECTIVES: This review aimed to synthesise international research about how intersectionality has been used to explore issues within the nursing profession. The objectives were to determine which intersecting variables have been explored, how intersectionality has been operationalised, and the implications for nursing leadership. BACKGROUND: Barriers to health system leadership created at the intersection of gender, race, ethnicity, professional cadre and other socially constructed categories exist in the health workforce. Consequently, an intersectionality paradigm has been recommended to explore power, privilege and oppression issues in the nursing profession. DESIGN: An integrative systematic review method was selected for its ability to include diverse methodologies. The review complies with the PRISMA guidelines for reporting systematic reviews. METHOD: The search terms nurs* nurses nursing AND Intersectionality intersectional intersectionalism, intersect were used in December 2021 to search the Cumulative Index to Nursing and Allied Health Literature (CINAHL Plus) PsycINFO, PubMed, Ovid, ProQuest and the first ten pages of Google Scholar from 2011 to 2021. Directed content analysis was applied to the data. RESULTS: Access to education, absence of expectations as a career and patriarchal structures support male nurses into positions of leadership in healthcare systems. Intra-group differences highlight the paradox of homogenous categories for ethnicity and gender. Being a member of an ethnic minority group hinders career progression regardless of gender. The aftereffects of colonisation exist within the nursing space. CONCLUSIONS: This review is the first to synthesise research using intersectionality to explore the impact of socially constructed identities on nursing leadership. There is a dearth of evidence specific to this topic, ignoring the diversity within this professional group. Future research should include intersectionality to discover how social categories empower or impede a nurse's career progression to leadership roles. RELEVANCE TO CLINICAL PRACTICE: An intersectionality paradigm can encourage nurses to attend to issues of power, privilege and oppression in the profession and their practice.


Assuntos
Etnicidade , Liderança , Humanos , Masculino , Enquadramento Interseccional , Grupos Minoritários
4.
J Clin Nurs ; 30(13-14): 1927-1941, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33760314

RESUMO

AIM: This study determines whether the culture within an acute care hospital empowers 'all' nurses to be leaders by exploring intersectionality and nursing leadership in the context of the social environment. BACKGROUND: Nurses practice leadership in their day-to-day activities as clinical leaders alongside traditional roles of management and leadership. However, some nurses do not acknowledge nursing work as leadership activity, nor is it seen so by others where hierarchical leadership approaches remain prevalent. Social constructs of gender and race are barriers to accessing formal leadership positions for some, while dominant power structures such as class diminish the value of bedside nursing work. Unexplored is the impact of the intersection of these and other social identities on nurses being leaders. DESIGN: An embedded case study design. METHODS: Thirty-one participants participated in semi-structured interviews. Four levels of analysis including inductive and deductive approaches were applied to the data. The research complied with COREQ guidelines for reporting qualitative research. RESULTS: This study shows nurses do not identify themselves as leaders without an associated title and the pathway to leadership varies depending on intersecting social constructions. CONCLUSION: The impact of the organisational structures and the experience of navigating intersecting social constructions on nurses being leaders goes unseen, privileging some while disadvantaging others. RELEVANCE TO CLINICAL PRACTICE: Health organisations need to be aware of intersectionality in the workplace and explore equity in their structures to be genuinely empowering. Nursing leadership must examine strategies that challenge and decolonise the nursing profession. Bedside nurses should be given more power and respected as leaders of the patient experience, achievable through a renewed emphasis on the fundamentals of care and resonant leadership, which can neutralise a culture of managerialism. Intersectionality can inform the development of new nursing leadership roles that enable nurses to remain clinically active, widening opportunities.


Assuntos
Liderança , Enfermeiras e Enfermeiros , Hospitais , Humanos , Nova Zelândia , Percepção
5.
J Interprof Care ; 33(6): 782-794, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30939956

RESUMO

Maintaining job satisfaction across the team in the operating room (OR) is essential for reducing staff turnover, stress, burnout, medical errors and increasing patient satisfaction. This literature review explores factors impacting on job satisfaction for OR team members, with a specific focus on nurses, anaesthetists and surgeons. A literature search from January 1997 to November 2017 was conducted using databases CINHAL, psychINFO, Medline and ABI/inform. Surgeon, anaesthetist, OR nurse and OR team job satisfaction studies were included. The search yielded 48 studies. Dominant contributing factors for all three disciplines included: work conditions, support and acknowledgement from management, and fulfilment from the clinical role. Career prospects, research opportunities, autonomy, utilising the full extent of one's skills, team dynamics/communication, pressure from management, and social support systems were also identified as significant for specific disciplines within the team. This review highlights the importance of addressing factors relating to job satisfaction from an 'OR team' perspective and considering the inter-relationship between roles. Further research into 'team satisfaction' in the OR, its measurement and its relationship with retention and productivity would be of benefit.


Assuntos
Relações Interprofissionais , Satisfação no Emprego , Salas Cirúrgicas , Equipe de Assistência ao Paciente , Humanos
6.
J Nurs Manag ; 26(7): 881-887, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-29675870

RESUMO

AIM: To examine clinical leadership of registered nurses in an emergency department, based on evidence that it is important for nurses to feel psychologically and structurally empowered in order to act as clinical leaders. BACKGROUND: Every registered nurse has the ability to act as a clinical leader. Clinical leadership is the registered nurse's behaviours that provide direction and support to patients and the team in the delivery of patient care. This study explores the connection between the need for structural and psychological empowerment and clinical leadership behaviours. METHODS: A mixed method, non-experimental survey design was used to examine the psychological empowerment, structural empowerment and clinical leadership of registered nurses working in an emergency department. RESULTS: Emergency department nurses believe they show clinical leadership behaviours most of the time, even though their sense of being psychologically empowered is only moderate. CONCLUSION: While registered nurses believe they perform clinical leadership behaviours, it is also clear that improvements in structural and psychological empowerment would improve their ability to act as clinical leaders. IMPLICATIONS FOR NURSING MANAGEMENT: The results show that for nurses to be able to provide clinical leadership to their patients and colleagues, management must create empowering environments.


Assuntos
Liderança , Enfermeiros Administradores/normas , Enfermeiras e Enfermeiros/psicologia , Poder Psicológico , Autonomia Profissional , Adulto , Serviço Hospitalar de Emergência/organização & administração , Feminino , Humanos , Satisfação no Emprego , Masculino , Pessoa de Meia-Idade , Enfermeiros Administradores/psicologia , Inquéritos e Questionários
7.
J Perianesth Nurs ; 32(6): 557-572, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29157762

RESUMO

PURPOSE: Internationally there is no consensus on the indicators essential for determining safe recovery from anesthesia and patient readiness for discharge from the postanesthesia care unit (PACU). DESIGN: Integrative review. METHODS: Using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) as a search strategy, the literature related to PACU discharge scores were evaluated and organized into themes. FINDINGS: The traditional components of airway support, oxygenation, sedation, and circulation are common within many first stage PACU discharge scores. However, there is strong support from the literature for components such as heart rate, temperature, pain, postoperative nausea and vomiting (PONV), urine output, and surgical site assessment to also be included. The review revealed that there is no standardized time frequency in applying a first stage PACU discharge score to patients within the PACU environment. CONCLUSIONS: There is a need for the development and trial of an evidence based first stage PACU discharge score.


Assuntos
Período de Recuperação da Anestesia , Enfermagem em Pós-Anestésico , Adulto , Idoso , Temperatura Corporal , Feminino , Frequência Cardíaca , Humanos , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória , Náusea e Vômito Pós-Operatórios , Micção
8.
Nurs Older People ; 29(7): 27-33, 2017 08 31.
Artigo em Inglês | MEDLINE | ID: mdl-28857007

RESUMO

Aim To establish the effectiveness of a restorative home support service on institutional-free survival in frail older people referred for needs assessment. Method A randomised controlled trial of Community Flexible Integrated Responsive Support Team versus usual care in 113 older people at risk of institutionalisation in New Zealand. Primary outcome was death or permanent institutional care evaluated in a Cox proportional hazards model adjusted for baseline prognostic variables. A variety of secondary outcomes including the health of informal caregivers were also evaluated. Results The primary outcome was lower, but not statistically significant, in the intervention group (adjusted hazard ratio 0.69, 95% confidence interval 0.4 to 1.16). Informal caregivers of interventional participants had significantly better physical and mental component scores on the 36-item Short-Form questionnaire. Conclusion Restorative home support may reduce the risk of death and institutionalisation in frail older people without affecting the health of informal caregivers.


Assuntos
Idoso Fragilizado/estatística & dados numéricos , Serviços de Assistência Domiciliar , Institucionalização/estatística & dados numéricos , Análise de Sobrevida , Idoso , Cuidadores/psicologia , Cuidadores/estatística & dados numéricos , Pesquisa sobre Serviços de Saúde , Humanos , Avaliação das Necessidades , Nova Zelândia , Encaminhamento e Consulta , Inquéritos e Questionários
9.
Appl Opt ; 55(6): 1481-9, 2016 Feb 20.
Artigo em Inglês | MEDLINE | ID: mdl-26906603

RESUMO

We describe the anisotropy in the material removal rate (MRR) of the polycrystalline, chemical-vapor deposited zinc sulfide (ZnS). We define the polycrystalline anisotropy via microhardness and chemical erosion tests for four crystallographic orientations of ZnS: (100), (110), (111), and (311). Anisotropy in the MRR was studied under magnetorheological finishing (MRF) conditions. Three chemically and mechanically modified magnetorheological (MR) fluids at pH values of 4, 5, and 6 were used to test the MRR variations among the four single-crystal planes. When polishing the single-crystal planes and the polycrystalline with pH 5 and pH 6 MR fluids, variations were found in the MRR among the four single-crystal planes and surface artifacts were observed on the polycrystalline material. When polishing the single-crystal planes and the polycrystalline with the modified MR fluid at pH 4, however, minimal variation was observed in the MRR among the four orientations and a reduction in surface artifacts was achieved on the polycrystalline material.

10.
Health Commun ; 30(8): 830-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-24901350

RESUMO

To date, there have been efforts toward creating better health information access for Deaf American Sign Language (ASL) users. However, the usability of websites with access to health information in ASL has not been evaluated. Our article focuses on the usability of four health websites that include ASL videos. We seek to obtain ASL users' perspectives on the navigation of these ASL-accessible websites, finding the health information that they needed, and perceived ease of understanding ASL video content. ASL users (n = 32) were instructed to find specific information on four ASL-accessible websites, and answered questions related to (a) navigation to find the task, (b) website usability, and (c) ease of understanding ASL video content for each of the four websites. Participants also gave feedback on what they would like to see in an ASL health library website, including the benefit of added captioning and/or signer model to medical illustration of health videos. Participants who had lower health literacy had greater difficulty in finding information on ASL-accessible health websites. This article also describes the participants' preferences for an ideal ASL-accessible health website, and concludes with a discussion on the role of accessible websites in promoting health literacy in ASL users.


Assuntos
Letramento em Saúde , Internet , Pessoas com Deficiência Auditiva/psicologia , Língua de Sinais , Gravação de Videoteipe , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoas com Deficiência Auditiva/estatística & dados numéricos , Estados Unidos , Adulto Jovem
11.
Age Ageing ; 43(3): 418-24, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24598085

RESUMO

BACKGROUND: frail older people often require tailored rehabilitation in order to remain at home, especially following a period of hospitalisation. Restorative care services aim to enhance an older person's ability to remain improve physical functioning, either at home or in residential care but evidence of their effectiveness is limited. OBJECTIVE: to evaluate the effectiveness of a restorative care service on institutional-free survival and health outcomes in frail older people referred for needs assessment in New Zealand. METHODS: a randomised controlled trial of restorative care or usual care in 105 older people at risk of permanent residential who were follow-up over 24 months. The restorative care service was delivered in short-stay residential care facilities and at participants' residences with the aim of reducing the requirement for permanent residential care. It included a comprehensive geriatric assessment and care plan developed and delivered, initially by a multi-disciplinary team and subsequently by home care assistants. RESULTS: compared with usual care, there was a non-significant absolute risk reduction of 14.3% for death or permanent residential care (8.8% for residential care and 7.2% for death alone) for the restorative care approach. There was no difference in levels of burden among caregivers. CONCLUSIONS: restorative care models that utilise case management and multi-disciplinary care may positively impact on institutional-free survival for frail older people without adversely impacting on the health of caregivers.


Assuntos
Serviços de Saúde para Idosos , Serviços de Assistência Domiciliar , Vida Independente/estatística & dados numéricos , Reabilitação , Instituições Residenciais/estatística & dados numéricos , Atividades Cotidianas , Idoso , Idoso de 80 Anos ou mais , Atenção à Saúde/métodos , Atenção à Saúde/organização & administração , Feminino , Idoso Fragilizado , Avaliação Geriátrica , Humanos , Masculino , Nova Zelândia , Alta do Paciente/normas , Avaliação de Programas e Projetos de Saúde , Reabilitação/métodos , Reabilitação/estatística & dados numéricos , Medição de Risco , Fatores de Risco , Análise de Sobrevida , Resultado do Tratamento
12.
Ann Surg ; 257(3): 527-33, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22968070

RESUMO

OBJECTIVE: Minimally invasive techniques have expanded the donor pool for living kidney donation. We changed our approach to single-port donor nephrectomy in 2009 and have compared outcomes with traditional multiple-port laparoscopic donor nephrectomy. BACKGROUND: The development of minimally invasive surgical techniques to procure kidneys from living donors has allowed expansion of living donor renal transplantation to account for one third of all renal transplants. Recent technical advancement allows for the entire surgical procedure to be done through a single incision contained within the umbilicus. METHODS: We compared outcomes from 135 single-port donor nephrectomies with an immediately preceding cohort of 100 multiple-port laparoscopic donor nephrectomies. Survey data were collected from both groups to compare outcomes. Additional comparisons were made to total center experience with 1300 laparoscopic donor nephrectomies. RESULTS: A total of 135 patients completed successful single-port donor nephrectomy without major complication or open conversion. Another 16 patients required additional port placement because of excessive intra-abdominal fat or limited abdominal domain. Compared with multiple-port donor nephrectomy, single-port patients had similar operative times to cross clamp (2.8 vs 2.6 hours; P = 0.11) that normalized after a learning curve of approximately 50 cases. Recipient creatinine levels were similar at 1 week and 1 month posttransplant. Although 36-Item Short Form Health Surveys demonstrated no significant differences, additional survey data revealed that single-port patients were more satisfied with cosmetic outcomes (P < 0.01) and the overall donation process (P = 0.01). Single-port approach had similar outcomes compared with all previous laparoscopic donor nephrectomies. CONCLUSIONS: Single-port donor nephrectomy can be integrated as a standardized approach for renal donation without additional donor risk, and with benefits of improved patient satisfaction with cosmetic and overall outcomes. Although the primary benefit is cosmetic, (a single incision predominantly contained within the umbilicus) outcomes justify application for kidney donors in experienced centers and may motivate additional living kidney donation.


Assuntos
Laparoscópios , Laparoscopia/métodos , Doadores Vivos , Nefrectomia/métodos , Satisfação do Paciente , Coleta de Tecidos e Órgãos/instrumentação , Adulto , Desenho de Equipamento , Feminino , Humanos , Transplante de Rim/métodos , Masculino , Estudos Retrospectivos
13.
Appl Opt ; 52(8): 1682-92, 2013 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-23478773

RESUMO

A low-temperature chemical cleaning approach has been developed to improve the performance of multilayer dielectric pulse-compressor gratings for use in the OMEGA EP laser system. X-ray photoelectron spectroscopy results guided the selection of targeted cleaning steps to strip specific families of manufacturing residues without damaging the grating's fragile 3D profile. Grating coupons that were cleaned using the optimized method consistently met OMEGA EP requirements on diffraction efficiency and 1054 nm laser-damage resistance at 10 ps. The disappearance of laser-conditioning effects for the highest-damage-threshold samples suggests a transition from a contamination-driven laser-damage mechanism to defect-driven damage for well-cleaned components.

14.
Australas Emerg Care ; 2023 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-37743125

RESUMO

BACKGROUND: Although efforts to reduce aggression and violence in emergency departments are important, it is also critical to minimise harm and support staff where this occurs. This research describes support mechanisms emergency nurses value when they experience occupational aggression and violence. METHODS: A mixed-methods design including thematic analysis of six interviews and descriptive analysis of fifty-one surveys, with experienced emergency nurse participants and respondents from a single large urban emergency department. RESULTS: Four key themes summarised coping with aggression and violence: Minimising exacerbating factors (mental health, lack of understanding of zero tolerance in practice, and wait times); Support before violence (use of huddles and having experienced nurses on each shift); Support during violence (education including restraint, self-defence, de-escalation and legalities); and Support after violence (debriefing, incident reporting and a sense of 'toughness') CONCLUSION: Emergency nurses need preparation and support to competently manage complex mental health presentations, understand legal rights, communicate effectively with patients, families and colleagues and access event debriefing. Security staff are valued team members but also need adequate resourcing and preparation.

15.
Age Ageing ; 41(6): 722-8, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22918089

RESUMO

INTRODUCTION: intermediate care has been developed to support older people to remain living in their own homes, combining a higher level of support with a rehabilitation focus. Evidence around their effectiveness remains mixed and there is ambiguity around the components. AIMS: to establish the impact of intermediate care on institutional free survival in frail older people referred for needs assessment in New Zealand (NZ). METHODS: pre-planned meta-analysis of three randomised controlled trials with follow-up at 3, 6, 12, 18 and 24 months. A total of 567 older people at risk of permanent institutionalisation as well as their primary informal carer (n = 234) were randomised to either intermediate or usual care. Interventions had common key features of care management, though varied in the use of ongoing care provision. RESULTS: the adjusted hazard ratio for the combined primary outcome of death or residential entry was 31% lower with a 95% confidence interval of (9%, 47%) for the intermediate care initiatives compared with usual care. CONCLUSION: intermediate care utilising a care management approach reduces a frail older person's risk of mortality and permanent institutionalisation.


Assuntos
Serviços de Saúde para Idosos/normas , Serviços de Assistência Domiciliar/normas , Instituições para Cuidados Intermediários/normas , Avaliação de Resultados em Cuidados de Saúde/normas , Ensaios Clínicos Controlados Aleatórios como Assunto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Institucionalização/normas , Masculino , Mortalidade/tendências , Nova Zelândia , Casas de Saúde/normas , Qualidade de Vida
16.
Compend Contin Educ Dent ; 42(7): 256-257, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34297591

RESUMO

There are many essential elements to achieving long-lasting esthetic and physiologic outcomes in implant dentistry in the esthetic zone. Here are three specialists take on the three most essential elements to implants in the esthetic zone.


Assuntos
Implantes Dentários para Um Único Dente , Implantes Dentários , Implantação Dentária Endóssea , Estética , Estética Dentária
17.
Artigo em Inglês | MEDLINE | ID: mdl-33671211

RESUMO

There is an intensification of work in global health systems, a phenomenon that could increase work-family conflict, exhaustion, and intentions to leave among healthcare workers. The main objective of this study is to analyze if daily work-family conflict and burnout could explain the daily leaving intentions and vitality of healthcare workers. This is a diary study, which employs an experience-sampling methodology (ESM). A total of 56 physicians, nurses, and nursing aides from intensive care and nephrology units filled out various quantitative scales during 5 working days (56 × 5 = 280 observations). Multilevel hierarchical analysis showed that daily work-family conflict and burnout were significantly associated with higher daily intentions of leaving the profession, and with lower levels of daily vitality. In addition, those workers who experienced more work-family conflict and depersonalization on a daily basis were those who showed more intentions to leave and less daily vitality, showing an interactive effect. The results highlight the importance of examining the psychosocial risks experienced by healthcare workers by employing experience-sampling methodologies, which could help us to deepen our understanding of the proximal antecedents of their intentions to leave and their psychological well-being.


Assuntos
Esgotamento Profissional , Médicos , Esgotamento Profissional/epidemiologia , Estudos Transversais , Conflito Familiar , Pessoal de Saúde , Humanos , Intenção , Inquéritos e Questionários
18.
Am J Kidney Dis ; 55(5): 907-15, 2010 May.
Artigo em Inglês | MEDLINE | ID: mdl-20176427

RESUMO

BACKGROUND: The role of smoking as a risk factor for adverse renal outcomes after kidney transplant has not been well studied. We therefore undertook this investigation to assess the association of smoking with transplant outcomes. STUDY DESIGN: Retrospective cohort study. SETTING & PARTICIPANTS: 997 consecutive laparoscopic live donor kidney transplant recipients at a tertiary-care transplant center. PREDICTOR: Smoking at the time of the transplant evaluation. OUTCOMES & MEASUREMENTS: Primary outcome is transplant survival. RESULTS: At the time of pretransplant evaluation, 329 participants had ever smoked and 668 participants had never smoked. Transplant survival was worse in ever smokers compared with never smokers (adjusted HR, 1.47; 95% CI, 1.08-1.99; P = 0.01), as was patient survival (adjusted HR, 1.60; 95% CI, 1.06-2.41; P = 0.02). First-year rejection-free survival was substantially worse (adjusted HR, 1.46; 95% CI, 1.05-2.03; P = 0.03) and risk of rejection on or before posttransplant day 10 was much higher (adjusted HR, 1.8; 95% CI, 1.10-2.94; P = 0.02) in ever smokers compared with never smokers. Glomerular filtration rate (estimated using the Modification of Diet in Renal Disease Study equation) at 1 year posttransplant was lower and poor early transplant function was more common in ever smokers on univariate, but not multivariate, analysis. LIMITATIONS: Lack of quantitation of smoking exposure and uncertainty about whether patients were still smoking at the time of transplant. CONCLUSIONS: Our results suggest that any history of smoking before transplant is associated with impaired transplant and patient survival and increases the risk of early rejection after live donor kidney transplant. Further study is needed to determine whether smoking may impart immunomodulatory and perhaps nephrotoxic effects.


Assuntos
Rejeição de Enxerto/epidemiologia , Transplante de Rim , Fumar/epidemiologia , Feminino , Taxa de Filtração Glomerular , Humanos , Transplante de Rim/efeitos adversos , Transplante de Rim/mortalidade , Transplante de Rim/fisiologia , Doadores Vivos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Análise de Sobrevida
19.
Opt Express ; 18(19): 19713-23, 2010 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-20940866

RESUMO

We use a recent experimental technique to measure in situ shear and normal stresses during magnetorheological finishing (MRF) of a borosilicate glass over a range of magnetic fields. At low fields shear stresses increase with magnetic field, but become field-independent at higher magnetic fields. Micromechanical models of formation of magnetic particle chains suggest a complex behavior of magnetorheological (MR) fluids that combines fluid- and solid-like responses. We discuss the hypothesis that, at higher fields, slip occurs between magnetic particle chains and the immersed glass part, while the normal stress is governed by the MRF ribbon elasticity.


Assuntos
Vidro/química , Modelos Químicos , Simulação por Computador , Módulo de Elasticidade , Campos Eletromagnéticos , Espalhamento de Radiação , Resistência ao Cisalhamento
20.
Appl Opt ; 49(10): 1951-63, 2010 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-20357881

RESUMO

We investigate the effects of processing parameters on material removal for borosilicate glass. Data are collected on a magnetorheological finishing (MRF) spot taking machine (STM) with a standard aqueous magnetorheological (MR) fluid. Normal and shear forces are measured simultaneously, in situ, with a dynamic dual load cell. Shear stress is found to be independent of nanodiamond concentration, penetration depth, magnetic field strength, and the relative velocity between the part and the rotating MR fluid ribbon. Shear stress, determined primarily by the material mechanical properties, dominates removal in MRF. The addition of nanodiamond abrasives greatly enhances the material removal efficiency, with the removal rate saturating at a high abrasive concentration. The volumetric removal rate (VRR) increases with penetration depth but is insensitive to magnetic field strength. The VRR is strongly correlated with the relative velocity between the ribbon and the part, as expected by the Preston equation. A modified removal rate model for MRF offers a better estimation of MRF removal capability by including nanodiamond concentration and penetration depth.

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