Detalhe da pesquisa
1.
Inhibition of mitochondrial fatty acid ß-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish.
J Biol Chem
; 299(10): 105220, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37660921
2.
Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking.
Proc Natl Acad Sci U S A
; 116(51): 25974-25981, 2019 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792171
3.
Chemical Synthesis, Pharmacokinetic Properties and Biological Effects of JM-00266, a Putative Non-Brain Penetrant Cannabinoid Receptor 1 Inverse Agonist.
Int J Mol Sci
; 23(6)2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35328343
4.
Deletion of lysophosphatidylcholine acyltransferase 3 in myeloid cells worsens hepatic steatosis after a high-fat diet.
J Lipid Res
; 62: 100013, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33518513
5.
Cannabinoid-1 Receptor Antagonism Improves Glycemic Control and Increases Energy Expenditure Through Sirtuin-1/Mechanistic Target of Rapamycin Complex 2 and 5'Adenosine Monophosphate-Activated Protein Kinase Signaling.
Hepatology
; 69(4): 1535-1548, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30506571
6.
Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice.
Hepatology
; 68(4): 1519-1533, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29631342
7.
Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.
Diabetes Obes Metab
; 20(3): 698-708, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29106063
8.
Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.
Proc Natl Acad Sci U S A
; 111(50): E5420-8, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25422468
9.
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.
Proc Natl Acad Sci U S A
; 110(47): 18832-7, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-24191036
10.
Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasing de novo synthesis of long-chain ceramides.
Hepatology
; 59(1): 143-53, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23832510
11.
Role of adiponectin in the metabolic effects of cannabinoid type 1 receptor blockade in mice with diet-induced obesity.
Am J Physiol Endocrinol Metab
; 306(4): E457-68, 2014 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24381003
12.
Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.
Hepatology
; 55(3): 790-9, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21987372
13.
A human laboratory study on the link between alcohol administration and circulating fibroblast growth factor 21 (FGF21) in individuals with alcohol use disorder.
Drug Alcohol Depend
; 245: 109809, 2023 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36822122
14.
Therapeutic potential of a novel peripherally restricted CB1R inverse agonist on the progression of diabetic nephropathy.
Front Nephrol
; 3: 1138416, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37675364
15.
Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via ß-arrestin1 in complex with TC-PTP and STAT3.
iScience
; 26(7): 107207, 2023 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37534180
16.
Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-ß receptors.
Cell Death Dis
; 13(9): 758, 2022 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36056008
17.
Endocannabinoids Produced by White Adipose Tissue Modulate Lipolysis in Lean but Not in Obese Rodent and Human.
Front Endocrinol (Lausanne)
; 12: 716431, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34434170
18.
Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB1R) Antagonist.
ACS Pharmacol Transl Sci
; 4(3): 1175-1187, 2021 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34151207
19.
CB1 R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky-Pudlak syndrome.
Clin Transl Med
; 11(7): e471, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34323400
20.
Different effects of pioglitazone and rosiglitazone on lipid metabolism in mouse cultured liver explants.
Diabetes Metab Res Rev
; 26(4): 297-305, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20503262