Detalhe da pesquisa
1.
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol Cell
; 53(2): 221-34, 2014 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24462203
2.
Functional divergence caused by mutations in an energetic hotspot in ERK2.
Proc Natl Acad Sci U S A
; 116(31): 15514-15523, 2019 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31296562
3.
OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function.
Mol Cell
; 45(3): 384-97, 2012 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22325355
4.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Nature
; 498(7454): 318-24, 2013 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23708998
5.
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Molecules
; 24(12)2019 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31226791
6.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Bioorg Med Chem
; 26(10): 2807-2815, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29598901
7.
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
Nature
; 466(7309): 941-6, 2010 Aug 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-20725033
8.
Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK.
Biochemistry
; 54(32): 5063-71, 2015 Aug 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26208601
9.
Protein kinase WNK3 regulates the neuronal splicing factor Fox-1.
Proc Natl Acad Sci U S A
; 109(42): 16841-6, 2012 Oct 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23027929
10.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.
Nat Commun
; 15(1): 489, 2024 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38216578
11.
Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.
J Biol Chem
; 285(33): 25161-7, 2010 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20525693
12.
Exquisitely Specific anti-KRAS Biodegraders Inform on the Cellular Prevalence of Nucleotide-Loaded States.
ACS Cent Sci
; 7(2): 274-291, 2021 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33655066
13.
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling.
Chem Sci
; 12(48): 15975-15987, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024121
14.
Radial spoke protein 3 is a mammalian protein kinase A-anchoring protein that binds ERK1/2.
J Biol Chem
; 284(43): 29437-45, 2009 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19684019
15.
De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits.
ACS Med Chem Lett
; 11(10): 1993-2001, 2020 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33062184
16.
Repurposing a Histamine Detection Platform for High-Throughput Screening of Histidine Decarboxylase.
SLAS Discov
; 23(9): 974-981, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29884090
17.
Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.
Structure
; 26(8): 1101-1115.e6, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29983373
18.
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.
Nat Biotechnol
; 36(1): 95-102, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29176614
19.
A strategy for modulation of enzymes in the ubiquitin system.
Science
; 339(6119): 590-5, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23287719
20.
Regulation of a third conserved phosphorylation site in SGK1.
J Biol Chem
; 284(6): 3453-60, 2009 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19068477