Detalhe da pesquisa
1.
Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells.
Nat Immunol
; 24(1): 174-185, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36564464
2.
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments.
Immunity
; 56(12): 2682-2698.e9, 2023 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-38091950
3.
A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.
Mol Cell
; 67(3): 498-511.e6, 2017 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28735895
4.
Switch-like activation of Bruton's tyrosine kinase by membrane-mediated dimerization.
Proc Natl Acad Sci U S A
; 116(22): 10798-10803, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31076553
5.
Stability of an autoinhibitory interface in the structure of the tyrosine kinase ZAP-70 impacts T cell receptor response.
Proc Natl Acad Sci U S A
; 106(49): 20699-704, 2009 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19920178
6.
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands.
Sci Signal
; 14(668)2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33531381
7.
Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.
Mol Cell Biol
; 25(12): 4924-33, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15923611
8.
Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.
Mol Cell Biol
; 24(6): 2455-66, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14993283
9.
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
Elife
; 52016 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27700984
10.
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
J Exp Med
; 213(2): 155-65, 2016 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26783323
11.
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Sci Signal
; 8(377): ra49, 2015 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25990959
12.
Structural basis for activation of ZAP-70 by phosphorylation of the SH2-kinase linker.
Mol Cell Biol
; 33(11): 2188-201, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23530057
13.
Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases.
Sci Signal
; 6(256): ra1, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23281368
14.
ZAP-70: an essential kinase in T-cell signaling.
Cold Spring Harb Perspect Biol
; 2(5): a002279, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20452964
15.
Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling.
J Biol Chem
; 283(22): 15419-30, 2008 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-18378687
16.
Structural basis for the inhibition of tyrosine kinase activity of ZAP-70.
Cell
; 129(4): 735-46, 2007 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-17512407