Nasal dilator and physiological parameters associated to running performance: A systematic review and meta-analysis.

Nasal dilators were created to expand the nasal valve area. The aim of this systematic review was to verify physiological parameters associated to running performance with the use of nasal dilators. This study was registered in PROSPERO (CRD42021225795). According to the PICOS framework studies were included: Population: healthy subjects; Intervention: nasal dilators; Comparison: control group, placebo, minimal intervention, health education or other intervention; Outcomes: cardiorespiratory parameters and subjective perceptions; Study: randomized controlled trials, repeated measures or within-subjects design. The databases searched were MEDLINE, EMBASE, CENTRAL The Cochrane Library, CINAHL, SPORTDiscus, Web of Science, PEDro and Scopus. The descriptors "Running", "Nasal Dilator", "Randomized Controlled Trial", and synonyms were used. The risk of bias was assessed using the PEDro scale. Random effects Der Simonian and Laird model were used. The assessment of the certainty of the evidence was carried out using the GRADE approach. Eleven articles were included. There was a difference in favour of the nasal dilator when compared to placebo for maximal oxygen uptake and rating of perceived exertion. The certainty of the evidence was very low. Future studies will probably have an impact on estimation of the effect.

Lipid production by yeasts grown on crude glycerol from biodiesel industry.

The main carbon source used for growth by four yeast strains (Yarrowia lipolytica CCMA 0357, Y. lipolytica CCMA 0242, Wickerhamomyces anomalus CCMA 0358, and Cryptococcus humicola CCMA 0346) and their lipid production were evaluated, using different concentrations of crude and pure glycerol and glucose. Whereas crude glycerol (100 g/L) was the main carbon source used by Y. lipolytica CCMA 0357 (nearly 15 g/L consumed at 120 hr) and W. anomalus CCMA 0358 (nearly 45.10 g/L consumed at 48 hr), pure glycerol (150 g/L) was the main one used by C. humicola CCMA 0346 (nearly 130 g/L consumed). On the other hand, Y. lipolytica CCMA 0242 used glucose (100 g/L) as its main source of carbon (nearly 96.48 g/L consumed). Y. lipolytica CCMA 0357 demonstrated the highest lipid production [about 70% (wt/wt)], forming palmitic (45.73% of fatty acid composition), stearic (16.43%), palmitoleic (13.29%), linolenic (10.77%), heptadecanoic (4.07%), and linoleic (14.14%) acids. Linoleic acid, an essential fatty acid, was produced by all four yeast strains but in varying degrees, representing 70.42% of the fatty acid profile of lipids produced by C. humicola CCMA 0346.

Environmental surface surveillance during a COVID-19 outbreak in a school community: implications for controlling indirect transmission.

Environmental surface surveillance is a valuable tool for detecting and controlling infectious diseases. During the COVID-19 pandemic, concerns have been raised regarding the potential for indirect transmission of SARS-CoV-2 via contaminated surfaces. However, few studies have evaluated environmental contamination in non-clinical settings during outbreaks. We conducted a study in a school community during a major outbreak, collecting 35 surface samples from high-traffic areas and testing them for SARS-CoV-2 RNA using RT-qPCR. Our results showed that 31.4% of samples were positive, including high-touch surfaces such as drinking fountains and washbasins. These findings emphasize the importance of environmental monitoring to identify and address specific areas for attention, and implementing such strategies can help prevent the indirect transmission of COVID-19 in various settings.

Tertiary treatment of dairy wastewater applying a microalga-fungus consortium.

This paper aimed to apply filamentous fungi (Penicillium oxalicum and Cunninghamella echinulata), the microalga Tetradesmus obliquus and their co-culture in advanced treatment (tertiary treatment) of cheese whey. The bioremediation process was carried out in agitated flasks and bubble column bioreactors with different concentrations of chemical oxygen demand (COD) (223-1663 mg L-1), total nitrogen (TN) (13-61 mg L-1), and total phosphorus (TP) (3-26 mg L-1). The results obtained in shaken flasks showed a superiority of the consortium compared to the systems with separated species. In this sense, the treatment was carried out in a bubble column reactor, and the consortium formed by the microalga and the fungus C. echinulata showed a greater efficiency (at a light intensity of 100 µmol m-2 s-1), promoting by the symbiosis to reach removal efficiencies of up to 93.7, 78.8 and 93.4% for COD, TN and TP, respectively; meeting Brazilian and European standards for discharge into water bodies. In addition, no pH adjustment was required during the co-culture treatment, demonstrating the buffering effect of using these two types of microorganisms. Therefore, the use of the consortium formed by T. obliquus and C. echinulata as a remediator was highly promising to promote the advanced treatment of cheese whey.

Dairy wastewater needs a polishing treatment stage after secondary treatmentThe microalga-fungus consortium met legislation requirementsCOD, nitrogen and phosphorus were efficiently removed by the consortiumNo pH control was applied during the biological treatment by the consortium.

Mental Health and Social Connectedness During the COVID-19 Pandemic: An Analysis of Sports and E-Sports Players.

Recently, the pandemic context in which the world finds itself has inspired studies that sought to evaluate to mental health and the way people are relating to the purpose of understanding and promoting improvements psychological health. The epidemiological and public health literature shows that social connection protects and promotes mental health, being an important clinical tool for reducing anxiety, depression, and stress. Thinking in the broad sense of connection, that is, feeling and perceiving oneself connected with the environment, applied to the context of sport, it is suggested that social connection could be related to the interactions in the practice of sport. Although playing sports can promote mental health, there are few findings on the topic in the context of a pandemic and with physical sports and electronic sports (e-sports) players. In this sense, the present study aims to assess the extent to which social connection and mental health indicators are correlated in a sample of sports and e-sports players. The participants were 401 Brazilian physical sports (N = 199, 49.6%) and e-sports players (N = 202, 50.4%), mostly male (53.1%) and single (59.9%), who filled in the Social Connectedness Scale (SCS), the Depression, Anxiety and Stress Scale (DASS), and demographic questions. The results indicated that social connection was negatively correlated and also predict the anxiety (r = -0.37), depression (r = -0.54), and stress (r = -0.39). When comparing sports and e-sports players, a statistically significant difference was identified in the levels of social connection [t(398) = -3.41; sportsmean (SD) = 4.53 (1.14); e-sportsmean (SD) = 4.14 (1.15)] and depression [t(396) = 2.90; sportsmean (SD) = 1.10 (0.89); e-sportsmean (SD) = 0.85 (0.81)]. These findings can serve as a theoretical basis for the development of intervention programs (e.g., to guide managers regarding the social distancing rules that enable them to keep holding sports practices and events) and promoting discussions that focus on the analysis of aspects promoting psychological health in sports context (physical and e-sports).

Ionic Channels as Potential Targets for the Treatment of Autism Spectrum Disorder: A Review.

Autism spectrum disorder (ASD) is a neurological condition that directly affects brain functions and can culminate in delayed intellectual development, problems in verbal communication, difficulties in social interaction, and stereotyped behaviors. Its etiology reveals a genetic basis that can be strongly influenced by socio-environmental factors. Ion channels controlled by ligand voltage-activated calcium, sodium, and potassium channels may play important roles in modulating sensory and cognitive responses, and their dysfunctions may be closely associated with neurodevelopmental disorders such as ASD. This is due to ionic flow, which is of paramount importance to maintaining physiological conditions in the central nervous system and triggers action potentials, gene expression, and cell signaling. However, since ASD is a multifactorial disease, treatment is directed only to secondary symptoms. Therefore, this research aims to gather evidence concerning the principal pathophysiological mechanisms involving ion channels in order to recognize their importance as therapeutic targets for the treatment of central and secondary ASD symptoms.

Anxiolytic and Antidepressant-like Effects of Monoterpene Tetrahydrolinalool and In silico Approach of new Potential Targets.

INTRODUCTION: Although drugs currently available for the treatment of anxiety and depression act through modulation of the neurotransmission systems involved in the neurobiology of the disorder, yet they often present side effects, which can impair patient adherence to treatment. METHODS: This has driven the search for new molecules with anxiolytic and antidepressant potential. Aromatic plants are rich in essential oils, and their chemical constituents, such as monoterpenes, are being studied for these disorders. This study aims to evaluate the anxiolytic and antidepressant-like potential of the monoterpene tetrahydrolinalool in in vivo animal models and review pharmacological targets with validation through molecular docking. Male Swiss mice (Mus musculus) were treated with THL (37.5-600 mg kg-1 p.o.) and submitted to the elevated plus maze, open field, rotarod, and forced swim tests. In the elevated plus-maze, THL at doses of 37.5 and 75 mg kg-1 induced a significant increase in the percentage of entries (72.7 and 64.3% respectively), and lengths of stay (80.3 and 76.8% respectively) in the open arms tests. RESULTS: These doses did not compromise locomotor activity or motor coordination in the animals. In the open field, rotarod tests, and the forced swimming model, treatment with THL significantly reduced immobility times at doses of 150, 300, and 600 mg kg-1, and by respective percentages of 69.3, 60.9 and 68.7%. CONCLUSION: In molecular docking assay, which investigated potential targets, THL presented satisfactory energy values for: nNOs, SGC, IL-6, 5-HT1A, NMDAr, and D1. These demonstrate the potential of THL (a derivative of natural origin) in in vivo and in silico models, making it a drug candidate.

Cross-cultural adaptation of body image assessment instruments for university students: a systematic review.

The theoretical-methodological process of cross-cultural adaptation of scales is fundamental for the expansion of research possibilities related to a given area and population, as instrument adequacy allows for the consistent assessment of the construct being studied. This article aims to highlight the different theoretical-methodological processes of cross-cultural adaptations of scales for assessing body image among young university students. The articles were selected in February 2020, with the following search descriptors: ("body image") and (young or "college students" or graduating or graduat *) and ("cross-cultural validation" or "cross-cultural adaptation"), in three databases-Scopus, PsycINFO, and Web of Science, without any time restrictions. Altogether, 304 studies were surveyed on the different bases mentioned above, and 14 studies published between 2010 and 2019 were evaluated. This study highlighted the methodological procedures used in the process of cross-cultural adaptation, as well as the population, the types of validity and reliability, and also the main limitations, strengths, and results reported in each study included in this review. The information presented in this review will allow new researchers to make more appropriate choices about instruments for assessing body image in young university students, in addition to presenting the methodological evolution on this theme.

[Women hospitalized due to abortion in a maternity teaching hospital in Recife, Brazil]. / Mulheres hospitalizadas por abortamento em uma Maternidade Escola na Cidade do Recife, Brasil.

This cross-sectional study was performed with 160 women between 2005-2006. The objective was to describe the social-demographic and reproductive characteristics of women hospitalized due to abortions, and their knowledge about contraceptive methods and abortion induction. In order to determine the association between the abortion classification and social-demographic variables, Pearson's chi-square test was used, with a significance level of 5%. A frequency of 56.3% was found for probably induced abortions. Most cases of abortion occurred before 12 weeks (55.7%). As for the women's profiles: 48.9% were between 20-29 years old, 72.0% had eight years or more of schooling, 90.1% had a partner, 52.0% had 1-3 children, 100% knew about oral contraceptives and condoms and 80.0% had heard about misoprostol. The social-demographic and reproductive profile of women hospitalized at the referred service due to abortion did not change over the last years. Misoprostol remains the most known method for abortion induction.

Early exposure to environment sounds and the development of cortical auditory evoked potentials of preterm infants during the first 3 months of life.

OBJECTIVE: Preterm infants are exposed earlier than their term counterparts to unattenuated sounds from the external environment during the sensitive period of the organization of the auditory cortical circuitry. In the current study, we investigate the effect of preterm birth on the course of development of auditory cortical areas by evaluating how gestational age (GA) correlates with the latency of the P1 component of the cortical auditory evoked potential (CAEP) of two experimental groups measured at 1 or 3 months of age. RESULTS: Our sample consisted of 23 infants delivered at GA ranging from 31.28 to 41.42 weeks and separated into two groups evaluated transversally at 1 or 3 months of corrected age (CA). In the group evaluated at 1-month CA, the latency of the component P1 was similar in both terms and infants classified as late-preterm (GA > 32 weeks). However, in the group evaluated at 3 months CA, P1 latency was significantly smaller in preterms. These preliminary results suggest an acceleration of the development of auditory cortical pathways in preterms, probably due to their early exposure to socially relevant auditory stimuli from the external environment.

Sociodemographic and Behavioral factors associated with Psychological Well-Being in a Brazilian Academic Community during the COVID-19 Pandemic / Fatores Sociodemográficos e Comportamentais Associados ao Bem-Estar Psicológico em uma Comunidade Acadêmica Brasileira Durante a Pandemia de COVID-19

Abstract This study aimed to identify sociodemographic and behavioral factors associated with the psychological well-being of university students at two distinct moments during the first year of the COVID-19 pandemic. It is an observational study with a cross-sectional design and convenience sampling, involving 2,808 university students who responded to a virtual form. The data were analyzed using descriptive and inferential statistics (Pearson's chi-square test, multiple binomial logistic regression with a significance level of 5%), after conducting normality tests. The results suggest negative impacts of the pandemic on the mental health of university students. A history of previous psychiatric alterations, having children, and having experienced financial difficulties were among the factors that contributed to the maintenance of some dimensions of psychological well-being.

Resumo Este estudo procurou identificar fatores sociodemográficos e comportamentais associados ao bem-estar psicológico de universitários em dois momentos distintos, durante o primeiro ano da pandemia de COVID-19. Trata-se de um estudo observacional, com desenho transversal e amostragem por conveniência, com 2.808 estudantes universitários que responderam a um formulário virtual. Os dados foram analisados por meio de estatísticas descritivas e inferenciais (teste Qui-Quadrado de Pearson, regressão logística binomial múltipla com nível de significância de 5%), após realização de testes de normalidade. Os resultados sugerem impactos negativos da pandemia na saúde mental dos universitários. Histórico de alterações psiquiátricas prévias, ter filhos e ter passado por dificuldades financeiras foram alguns dos fatores que contribuíram para a manutenção de algumas dimensões do bem-estar psicológico.

Men's mental health in a university community during the COVID-19 pandemic / Saúde mental masculina em uma comunidade universitária durante a pandemia de COVID-19

Objective This study aims to identify associations between sociodemographic characteristics and mental health, behaviors, and perceptions among men in a Brazilian university community during the COVID-19 pandemic. Method A total of 862 subjects participated, responding to an online questionnaire with sociodemographic questions, the Depression, Anxiety, and Stress Scale, and the Psychological Well-Being scale. Results The results indicate that sociodemographic characteristics are associated with the mental health, behaviors, and perceptions of the participants. Variables such as age, race, occupation, marital status, and living arrangements during the period of social distancing relate in different ways to levels of anxiety, stress, and depression, as well as psychological well-being, in addition to behaviors and perceptions during the COVID-19 pandemic. Conclusion The results highlight the need to consider the specificities of the male population facing the COVID-19 pandemic and emphasize the importance of investing in health actions that consider the influence of the process of social construction of masculinities.

Objetivo Esse estudo tem por objetivo identificar associações de características sociodemográficas com a saúde mental, comportamentos e percepções entre homens de uma comunidade universitária brasileira durante a pandemia de COVID-19. Método Participaram 862 sujeitos, os quais responderam a um formulário online com questões sociodemográficas e às escalas de Depressão Ansiedade e Estresse e a Escala de Bem-Estar Psicológico. Resultados Os resultados apontam que características sociodemográficas mostram-se associadas à saúde mental, comportamentos e percepções dos participantes. Variáveis como faixa etária, raça/cor, ocupação, estado civil e moradia, durante o período de distanciamento, estão relacionadas de maneiras diferentes a níveis de ansiedade, estresse e depressão, bem como, de bem-estar psicológico, além dos comportamentos e percepções durante a pandemia de COVID-19. Conclusão Os resultados apontam para a necessidade de se considerar as singularidades da população masculina diante da pandemia de COVID-19 e ressaltam a importância do investimento em ações em saúde que considerem a influência do processo de construção social das masculinidades.

Dependência do smartphone: relação entre procrastinação, saúde geral e valores humanos / Dependencia del smartphone: relación entre procrastinación, salud general y valores humanos / Smartphone addiction: relationship between procrastination, general health and human values

Esta pesquisa objetivou conhecer o papel preditivo dos valores humanos, da procrastinação e da saúde geral com relação à dependência do smartphone. Contou-se com a participação de 390 pessoas da população geral, com idades variando de 18 a 69 anos (M=27,DP=8,91), sen-do a maioria do sexo feminino (71%). Estes responderam à Escala de Dependência do Smartpho-ne (versão reduzida), Escala de Procrastinação de Tuckman, Questionário de Saúde Geral (QSG-12), Questionário dos Valores Básicos (QVB)e perguntas demográficas. Os resultados indicaram que a dependência do smartphone está positivamente relacionada à procrastinação, resultando em prejuízos à saúde geral, tais como níveis maiores de ansiedade e depressão. Conclui-se que os valores, a procrastinação e os níveis de ansiedade atuam como importantes preditores para o comportamento dependente do smartphone. (AU)

This research aimed to understand the predictive role of human values, procrastination and general health in relation to smartphone dependence. Participated 390 people from the gen-eral, with ages ranging from 18 to 69 years old (M=27, SD=8.91), mostly female (71%). They answered the Smartphone Addiction Scale (SAS, reduced version), Tuckman's Procrastination Scale, General Health Questionnaire (GHQ-12), Basic Values Survey (BVS) and demographic questions. The results indicating that smartphone dependence is positively related to procras-tination, resulting in damage to general health, such as higher levels of anxiety and depres-sion. It was concluded that values, procrastination and anxiety levels were shown to be im-portant predictors for smartphone-dependent behavior. (AU)

Association between religion, mental health and social distancing during the Covid-19 pandemic / Associação entre religião, saúde mental e distanciamento social na pandemia de Covid-19 / Asociación entre religión, salud mental y distanciamiento social en la pandemia Covid-19

This cross-sectional study aimed to analyze the association of religiosity with behaviors and perceptions in the context of social distancing measures during the COVID-19 pandemic, as well as mental health outcomes, in a university community in Central-West Brazil. A sample of 1,796 subjects responded to an online form with socio-demographic questions and the DASS-21 and PWBS scales. Religion was associated with the frequency of interactions, perceptions of the duration of the social distancing measures, changes in emotional state and history of psychological illness. The prevalence of symptoms of depression, anxiety and stress was lower among people with religion and their scores in psychological well-being were higher. (AU)

Trata-se de um estudo transversal com o objetivo de analisar a associação entre religiosidade e comportamentos e percepções frente ao distanciamento social decorrente da pandemia de Covid-19 e estado de saúde mental em uma comunidade universitária do Centro-Oeste brasileiro. Participaram do estudo 1796 sujeitos, os quais responderam a um formulário online com questões sociodemográficas e às escalas DASS-21 e EBEP. Observou-se associação entre religião e frequência de interações, percepção sobre a duração do distanciamento social e mudanças no estado emocional e histórico de alterações psicológicas. Constatou-se menor prevalência de sintomas relacionados à depressão, à ansiedade e ao estresse e maiores escores de bem-estar psicológico entre aqueles com religião. (AU)

Se trata de un estudio transversal con el objetivo de analizar la asociación entre religiosidad, comportamientos y percepciones frente al distanciamiento social resultante de la pandemia Covid-19 y el estado de salud mental en una comunidad universitaria de la región Centro-Oeste de Brasil. Participaron en el estudio 1796 sujetos, que respondieron un formulario en línea con preguntas sociodemográficas y las escalas DASS-21 y EBEP. Se observó asociación entre religión y frecuencia de interacciones, la percepción de la duración del aislamiento social y los cambios en el estado emocional y el historial de cambios psicológicos. Se observó una menor prevalencia de síntomas relacionados con la depresión, la ansiedad y el estrés, y puntuaciones más altas de bienestar psicológico entre quienes profesaban una religión. (AU)

Game Behavior Scale-Electronic (GBS-E): elaboration and psychometric evidence / Escala de Comportamento em Jogo - Eletrônico (ECJ-E): elaboração e evidências psicométricas / Escala de comportamiento en el juego - Electrónico (ECJ-E): elaboración y evidencias psicométricas

Despite the growing engagement in electronic games globally and the need to measure behavior in this context, there are few instruments for this purpose. The present study aimed to develop and validate the Game Behavior Scale-Electronic (GBS-E) in Brazil. In Study 1 (N=409), exploratory factor analysis supported the adequacy of a two-factor solution (individual and collective behavior). In Study 2 (N=373), we used confirmatory factor analysis, item response theory (to evaluate the discrimination and difficulty levels), and graphical factor analysis to test the above version of the scale and propose a short form of the GBS-E. The results suggest that both forms (full form, 31 items and short form, 10 items) of the GBS-E demonstrate psychometric evidence (factorial validity and internal consistency) for the adequacy of the measure to evaluate individual and collective behavior in electronic games. (AU)

Apesar do avanço da prática do esporte eletrônico a nível global e da necessidade de mensurar comportamentos neste contexto, são escassos na literatura instrumentos para este fim. Assim, o presente estudo objetivou elaborar e validar a Escala de Comportamento em Jogo - Eletrônico (ECJ-E) em uma amostra brasileira. No Estudo 1 (N=409) uma análise fatorial exploratória suportou a adequação de uma solução bifatorial (comportamento individual e coletivo). No Estudo 2 (N=373), utilizou-se de análise fatorial confirmatoria, da Teoria de Resposta ao Item (para avaliar os níveis de discriminação e dificuldade) e da análise fatorial gráfica para testar a versão do estudo anterior e propor uma forma curta da ECJ-E. Os resultados sugerem que tanto a forma completa (31 itens) quanto a curta (10 itens) da ECJ-E fornecem evidências psicométricas (validade fatorial e consistência interna) de adequação da medida para avaliar o comportamento individual e coletivo em jogo - eletrônico. (AU)

A pesar del avance de los deportes electrónicos a nivel mundial y la necesidad de medir comportamientos en este contexto, los instrumentos para tal fin son escasos en la literatura. El presente estudio tuvo como objetivo desarrollar y validar la Escala de Comportamiento en el Juego - Electrónico (ECJ-E) en una muestra brasileña. En el Estudio 1 (N=409), un análisis factorial exploratorio apoyó la idoneidad de una solución de dos factores (comportamiento individual y colectivo). En el Estudio 2 (N=373), utilizamos el análisis factorial confirmatorio, la Teoría de la Respuesta al Ítem (para evaluar los niveles de discriminación y dificultad) y el análisis factorial gráfico para probar la versión del estudio anterior y proponer un formulario breve. Los resultados sugieren que el formulario completo (31 ítems) y el breve (10 ítems) del ECJ-E aportan evidencias psicométricas (validez factorial y consistencia interna) de la adecuación de la medida para evaluar el comportamiento individual y colectivo en los juegos electrónicos. (AU)

Cuidado clínico farmacêutico e estratégia para o uso racional e adesão ao tratamento em pacientes com hanseníase numa Policlínica do Recife / Pharmaceutical clinical care and strategy to rational use and adhesion to treatment in Hansen's disease patients at a policlinic from Recife

Introdução: a hanseníase é uma doença de fácil diagnóstico, possuindo tratamento e cura. Quando diagnosticada tardiamente, pode trazer graves consequências para os portadores e seus familiares. Uma vez que o tratamento da hanseníase está inserido no componente estratégico da assistência farmacêutica, são exigidos cuidados e orientação. Há necessidade de intervenção clínica farmacêutica, com objetivo de acompanhar prescrições medicamentosas, analisando a adesão dos pacientes ao tratamento com a promoção de ações de educação em saúde, além de minimizar a ocorrência de eventos adversos relacionados aos fármacos do tratamento com possível redução de custos associados aos agravos. Objetivo: realizar o monitoramento para identificar e tratar as possíveis intercorrências que estão comumente presentes no tratamento de hanseníase. Metodologia: a realização do estudo deu-se com o acompanhamento dos pacientes atendidos no serviço de referência a partir da aplicação de questionários em consultas periódic as, vis to que a adesão ao tratamento, reduç ão dos eventos adver sos e controle dos comunic antes são de suma impor tância para o controle epidemiológico. Resultados: os principais sintomas dos indivíduos acometidos foram dormência e eritema nodoso hansênico. A maioria utilizava como tratamento o esquema multibacilar e talidomida. O acometimento relatado dos pacientes foi em nível moderado. Os pacientes possuíam comorbidades como hipertensão, artrose e diabetes. O acompanhamento clínico foi relatado como positivo pela maioria dos entrevistados. Conclusão: o desfecho do estudo mostra que a adesão do paciente é crucial para o êxito do tratamento e o acompanhamento do farmacêutico clínico constitui um pilar positivo, contribuindo para a prevenção de agravos e conscientização da comunidade.

Introduction: Hansen's disease is an easily diagnosed disease, with treatment and cure available. When diagnosed late, it can bring serious consequences for patients and their families. Since the treatment of Hansen's disease is part of the strategic component of pharmaceutical assistance, care and guidance are required. There is a need for clinical pharmaceutical intervention, aiming to monitor drug prescriptions, analyze patients' adherence to treatment while promoting health education actions, in addition to minimizing the occurrence of adverse events related to treatment drugs with possible reduction in costs associated to grievances. Objective:thus, the present study aimed to monitor, identify, and treat possible complications commonly present in the treatment of Hansen's disease. Methodology: The study was carried out with the follow-up of patients seen at the reference service, through the application of questionnaires in periodic appointments, since adherence to treatment, reduction of adverse events and control of communicants are of short importance for epidemiological control. Results:The main symptoms of Hansen's disease patients were numbness and leprosy nodosum erythema. Most used the multibacillary scheme and thalidomide as treatment. The reported involvement of patients was at a moderate level. Patients had other comorbidities such as hypertension, arthrosis and diabetes. The clinical assistance was reported as positive by most interviewees. Conclusion: The outcome of the study shows that patient's compliance is crucial for the success of treatment and the clinical pharmacist's accompaniment is a positive pillar, contributing to the prevention of complications and community awareness.

Impacto das Teorias da Conspiração em tempos de COVID-19: Uma Revisão da Literatura / The Impact of Conspiracy Theories in Times of COVID-19: A Literature Review / Impacto de las Teorías de la Conspiración en tiempos de COVID-19: Una Revisión de la Literatura

Na conjuntura atual, a COVID- 19 representa uma séria ameaça ao bem-estar físico e psicológico da comunidade global. Por se tratar de um vírus com elevado potencial de transmissão, as orientações da Organização Mundial de Saúde para reduzir sua proliferação envolvem medidas sanitárias e ações de isolamento social. Dentre os aspectos de cunho psicológico que podem afetar as decisões de conformidade com as ações de isolamento social, pode-se consi-derar a crença em teorias da conspiração. Considerando a influência que tais teorias exercem sobre o comportamento das pessoas, o presente artigo teórico teve como objetivo delinear o panorama vigente sobre o estudo das crenças em teorias da conspiração no contexto da pandemia da COVID-19, bem como discutir o impacto que as mesmas exercem sobre a saúde e a conduta dos indivíduos. Em suma, este trabalho fornece subsídios para a ampliação dessa discussão a nível teórico e para o desenvolvimento de estudos empíricos consi-derando a realidade brasileira.

In the actual scenario, COVID-19 represents a serious threat to the physical and psychological well-being of the global population. The new coronavirus (SARS-COV-2) is highly contagious and easily transmitted; in this sense, the guidelines provided by the World Health Organization (WHO) to reduce this contamination involve sanitary actions and measures such as social isolation. Amongst the psychological aspects that might affect decisions on whether to follow such measures, we can highlight conspiracy theories beliefs. Considering the influence that such theories have on people's behaviors, the current theo-retical paper aims to provide an overview of studies on beliefs in conspiracy theories in the context of the COVID-19 pandemic, as well as to discuss the impact that they have over people's health and behavior. In summary, this paper provides resources to amplify this discussion on a theoretical level and to develop empirical studies considering the Brazilian reality.

En la coyuntura actual, la COVID-19 representa una seria amenaza para el bienestar físico y psicológico de la comunidad global. El nuevo coronavirus (SARS-COV-2) tiene un alto potencial de transmisión, en este sentido, los lineamientos de la Organización Mundial de la Salud para reducir su prolife-ración involucran medidas sanitarias y acciones de aislamiento social. Entre los aspectos psicológicos que pueden afectar las decisiones para cumplir con las acciones de aislamiento social, se puede considerar la creencia en teorías de la conspiración. Considerando la influencia que tales teorías tienen en el comportamiento de las personas, este artículo teórico tuvo como objetivo esbozar el panorama imperante en el estudio de las creencias en las teorías conspirativas en el contexto de la pandemia de COVID-19, así como el impacto que tienen en la salud y la conducta de las personas. En definitiva, el trabajo brinda apoyo para ampliar las discusiones a nivel teórico y para el desarrollo de estudios empíricos considerando la realidad brasileña.

High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster: Protective role of Syzygium cumini and Bauhinia forficata.

Diet is a key component for development and longevity of organisms. Here, the fruit fly was used to evaluate the detrimental effects caused by consumption of high-sucrose diets (HSD), namely phenotypic responses linked to insulin signaling and oxidative stress. The protective effects of extracts from medicinal plants Syzygium cumini and Bauhinia forficata were investigated. HSD intake (15% and 30%) delayed the time to pupation and reduced the number of white pupae. In adult flies, the intake of diets was associated with mortality and increased levels of glucose+trehalose, triacylglycerols and hydrogen peroxide. Indeed, 30% HSD induced body-weight loss, mitochondrial dysfunction and changes in acetylcholinesterase, δ-aminolevulinate dehydratase and antioxidant enzymes activity. Catalase, superoxide dismutase, keap1, HSP70, dILP-5 and Insulin receptor mRNA levels were over-expressed in flies emerged from 30% HSD. The extract treatments blunted the developmental alterations elicited by diets. Syzygium cumini extract was more efficient than B. forficata in reducing hyperglycaemia, redox disturbances and the changes in mRNA expression of insulin receptor.

Procrastinar academicamente é coisa de perfeccionista? Correlatos valorativos e da personalidade / ¿Procrastinar académicamente es una cuestión perfeccionista? Correlación entre el valor y la personalidad / Procrastinating Academically is Something of a Perfectionist? Value and Personality Correlations

Resumo O presente estudo objetivou conhecer o poder preditivo dos traços de personalidade, dos valores humanos e do perfeccionismo para com a procrastinação acadêmica, propondo um modelo explicativo. Participaram 348 universitários, a maioria do sexo feminino (58.4 %), com idade média de 22 anos (DP = 5.9). Estes, responderam a Escala de Procrastinação Acadêmica; a Escala de Quase Perfeição - Revisada; o Questionário dos Valores Básicos; o Inventário dos Cinco Grandes Fatores da Personalidade e perguntas demográficas. Baseado na regressão, propôs-se um modelo explicativo no qual a conscienciosidade predisse as dimensões de perfeccionismo (adaptativo e desadaptativo) e estas, por sua vez, predisseram a procrastinação acadêmica. Os resultados apontam para um ajuste satisfatório deste modelo que contribuem para o entendimento da procrastinação acadêmica.

Resumen Este estudio tuvo como objetivo comprender el poder predictivo de los rasgos de personalidad, los valores humanos y el perfeccionismo hacia la procrastinación académica, proponiendo un modelo explicativo. Participaron 348 estudiantes universitarios, la mayoría mujeres (58.4 %), con una edad media de 22 años (DE = 5.9). Estas respondieron a la Escala de Procrastinación Académica; la Escala de Casi Perfección - Revisada; el Cuestionario de Valores Básicos; el Inventario de los Cinco Grandes Factores de la Personalidad y preguntas demográficas. A partir de un análisis de regresión, se propuso un modelo explicativo en el que la escrupulosidad predijo las dimensiones del perfeccionismo (adaptativo y desadaptativo) y estas, a su vez, predijeron la procrastinación académica. Los resultados apuntan a un ajuste satisfactorio de este modelo que contribuye a la comprensión de la procrastinación académica.

Abstract The present study aimed at discerning the predictive power of personality traits, human values, and perfectionism towards academic procrastination, proposing an explanatory model. Participants were 348 undergraduates, most of them female (58.4 %), with a mean age of 22 years (SD = 5.9). They answered the Academic Procrastination Scale, the Almost Perfect Scale - Revised, the Basic Values Survey, the Big Five Inventory, and demographic questions. Based on regression analysis, an explanatory model was proposed where conscientiousness predicted the dimensions of perfectionism (adaptive and maladaptive) that in turn predicted academic procrastination. Results suggested a satisfactory fit of the model to the indices that contributes to the understanding of academic procrastination.

Fenômeno do Impostor e Perfeccionismo: Avaliando o Papel Mediador da Autoestima / Impostor Phenomenon and Perfectionism: Evaluating the Mediator role of Self-esteem / Fenómeno del Impostor y Perfeccionismo: Evaluando el papel Mediador de la Autoestima

Na literatura, o perfeccionismo tem sido relacionado ao fenômeno do impostor. Contudo, são escassas as pesquisas que analisam conjuntamente estas relações. Esta pesquisa examina o potencial papel mediador da autoestima na relação entre as dimensões do perfeccionismo (adaptativo e desadaptativo) e o fenômeno impostor. Participaram da pesquisa 380 universitários, com idade média 24 anos (DP= 5,69; 18 a 55 anos), a maioria do sexo feminino (63%). Estes responderam a Escala de Quase Perfeição-Revisada, a Escala Clance de Fenômeno Impostor, a Escala de Autoestima e perguntas demográficas. Realizaram-se análises de correlação e regressão, tendo os resultados indicado que pessoas com maiores níveis de impostorismo apresentaram menos autoestima e mais perfeccionismo desadaptativo. Por sua vez, a autoestima se correlacionou positivamente com o perfeccionismo adaptativo e negativamente com o desadaptativo. Por meio de duas path analysis identificou-se que a autoestima mediou parcialmente a relação entre o perfeccionismo (desadaptativo e adaptativo) e o fenômeno do impostor, sendo maior o efeito no caso do perfeccionismo desadaptativo. Conclui-se que a autoestima é uma variável importante para a compreensão da relação entre o impostorismo e o perfeccionismo, reforçando que pessoas com mais autoestima e menos desadaptativamente perfeccionistas costumam vivenciar menos o fenômeno do impostor. (AU)

In the literature, perfectionism has been related to the impostor phenomenon However, there is scant research that analyze jointly this relationship. This study aimed to examine the potential mediating role of self-esteem in the relationship between dimensions of perfectionism (adaptive and maladaptive) and the impostor phenomenon. Participants were 380 undergraduate students, with a mean age of 24 years (SD = 5.69, 18-55 years), mostly females (63%). They answered the Almost Perfect Scale-Revised, Clance Impostor Phenomenon Scale, the Self-Esteem Scale, and demographic questions. Correlation and regression analysis were performed, with the results indicated that people with higher levels of impostorism had less self-esteem and more maladaptive perfectionism. On the other side, self-esteem correlated positively with adaptive perfectionism and negatively with the maladaptive one. Through two-path analysis, it was identified that self-esteem partially mediated the relationship between perfectionism (maladaptive and adaptive) and impostor feelings, being greater the effect in the case of maladaptive perfectionism. We concluded that self-esteem is an important variable for understanding the relationship between impostorism and perfectionism, reinforcing that people with more self-esteem and less maladaptive perfectionists usually experience less the impostor phenomenon. (AU)

En la literatura, el perfeccionismo se ha relacionado con el fenómeno del impostor. Sin embargo, hay poca investigación sobre los mecanismos subyacentes de esta relación. Esta investigación tiene como objetivo examinar el posible papel mediador de la autoestima en la relación entre las dimensiones del perfeccionismo (adaptativo y desadaptativo) y el fenómeno impostor. Participaron del estudio un total de 380 universitarios, con una edad media de 24 años (DE = 5.69, 18-55 años), la mayoría mujeres (63%). Estos respondieron a la Escala de Casi Perfección Revisada, la Escala Clance del Fenómeno Impostor, la Escala de Autoestima y preguntas demográficas. Se realizaron análisis de correlación y regresión, y los resultados indicaron que las personas con niveles más altos de impostorismo tenían menos autoestima y más perfeccionismo inadaptado. Mientras tanto, la autoestima se correlacionó positivamente con el perfeccionismo adaptativo y negativamente con el desadaptativo. Mediante análisis de dos vías se identificó que la autoestima mediaba parcialmente la relación entre el perfeccionismo (desadaptativo y adaptativo) y el fenómeno del impostor, siendo mayor el efecto en el caso del perfeccionismo desadaptativo. Se concluye que la autoestima es una variable importante para comprender la relación entre el impostorismo y el perfeccionismo, lo que refuerza que las personas con más autoestima y menos desadaptativamente perfeccionistas suelen experimentar menos el fenómeno del impostor. (AU)