Detalhe da pesquisa
1.
USP Apparatus 4: a Valuable In Vitro Tool to Enable Formulation Development of Long-Acting Parenteral (LAP) Nanosuspension Formulations of Poorly Water-Soluble Compounds.
AAPS PharmSciTech
; 19(1): 413-424, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-28755052
2.
Amorphization of itraconazole by inorganic pharmaceutical excipients: comparison of excipients and processing methods.
Pharm Dev Technol
; 20(1): 118-27, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25312240
3.
Structure-Based Design of an Iminoheterocyclic ß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
J Med Chem
; 59(7): 3231-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937601
4.
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(23): 10435-10450, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933948
5.
Cyclic hydroxyamidines as amide isosteres: discovery of oxadiazolines and oxadiazines as potent and highly efficacious γ-secretase modulators in vivo.
J Med Chem
; 55(1): 489-502, 2012 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22098494
6.
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
J Med Chem
; 55(21): 9331-45, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989333