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Proc Natl Acad Sci U S A ; 111(22): 8119-24, 2014 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-24843175

RESUMO

Oxidative stress (an overproduction of reactive oxygen species in relation to defense mechanisms) may restrict investment in life history traits, such as growth, reproduction, lifespan, and the production of sexual signals to attract mates. The constraint on sexual signaling by oxidative stress is of particular interest because it has been proposed as a mechanism ensuring that only good-quality males produce the most attractive sexual signals. Despite these predictions, evidence supporting this theory is, at best, equivocal. We used a superoxide dismutase knockout mouse to demonstrate that oxidative stress directly impairs investment in morphological (preputial glands) and molecular (major urinary proteins) components of olfactory signaling essential for mate attraction. By maintaining males in a much more competitive environment than usual for mouse laboratory experiments, we also revealed a range of phenotypes of superoxide dismutase deficiency not observed in previous studies of this mouse model. This range included impaired bioenergetic function, which was undetectable in the control environment of this study. We urge further examination of model organisms in seminatural conditions and more competitive laboratory environments, as important phenotypes can be exposed under these more demanding conditions.


Assuntos
Estresse Oxidativo/fisiologia , Atrativos Sexuais/fisiologia , Comportamento Sexual Animal/fisiologia , Olfato/fisiologia , Superóxido Dismutase/genética , Superóxido Dismutase/metabolismo , Animais , Comportamento Competitivo/fisiologia , Metabolismo Energético/fisiologia , Feminino , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Knockout , Fenóis/metabolismo , Extratos Vegetais/metabolismo , Transdução de Sinais/fisiologia , Meio Social , Superóxido Dismutase-1 , Territorialidade
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