Detalhe da pesquisa
1.
Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.
Nucleic Acids Res
; 50(2): 962-974, 2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35037018
2.
Resistance of mitochondrial DNA to cadmium and Aflatoxin B1 damage-induced germline mutation accumulation in C. elegans.
Nucleic Acids Res
; 50(15): 8626-8642, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35947695
3.
PolyG-DS: An ultrasensitive polyguanine tract-profiling method to detect clonal expansions and trace cell lineage.
Proc Natl Acad Sci U S A
; 118(31)2021 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34330826
4.
A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.
Nucleic Acids Res
; 49(19): 11103-11118, 2021 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614167
5.
Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes.
Proc Natl Acad Sci U S A
; 116(8): 3062-3071, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30718408
6.
Targeted genome fragmentation with CRISPR/Cas9 enables fast and efficient enrichment of small genomic regions and ultra-accurate sequencing with low DNA input (CRISPR-DS).
Genome Res
; 28(10): 1589-1599, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30232196
7.
Aging and the rise of somatic cancer-associated mutations in normal tissues.
PLoS Genet
; 14(1): e1007108, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29300727
8.
Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ.
PLoS Genet
; 14(11): e1007805, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30452458
9.
Ultra-deep sequencing detects ovarian cancer cells in peritoneal fluid and reveals somatic TP53 mutations in noncancerous tissues.
Proc Natl Acad Sci U S A
; 113(21): 6005-10, 2016 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27152024
10.
Volatility of Mutator Phenotypes at Single Cell Resolution.
PLoS Genet
; 11(4): e1005151, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25868109
11.
Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage.
Ann Neurol
; 80(2): 301-6, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27315116
12.
Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations.
PLoS Genet
; 10(2): e1003974, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24516391
13.
Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.
PLoS Genet
; 9(9): e1003794, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24086148
14.
Detection of ultra-rare mutations by next-generation sequencing.
Proc Natl Acad Sci U S A
; 109(36): 14508-13, 2012 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-22853953
15.
Templated nucleoside triphosphate binding to a noncatalytic site on RNA polymerase regulates transcription.
Proc Natl Acad Sci U S A
; 108(15): 6079-84, 2011 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21447716
16.
Frequencies and spectra of aflatoxin B1-induced mutations in liver genomes of NEIL1-deficient mice as revealed by duplex sequencing.
NAR Mol Med
; 1(2): ugae006, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38779538
17.
Targeted accurate RNA consensus sequencing (tARC-seq) reveals mechanisms of replication error affecting SARS-CoV-2 divergence.
Nat Microbiol
; 9(5): 1382-1392, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38649410
18.
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.
Elife
; 122023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36799304
19.
The Complicated Nature of Somatic mtDNA Mutations in Aging.
Front Aging
; 22022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35252966
20.
Myometrial oxidative stress drives MED12 mutations in leiomyoma.
Cell Biosci
; 12(1): 111, 2022 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35869560