Detalhe da pesquisa
1.
Highly predictive and interpretable models for PAMPA permeability.
Bioorg Med Chem
; 25(3): 1266-1276, 2017 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28082071
2.
An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software.
Drug Metab Dispos
; 44(10): 1653-61, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27417180
3.
Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.
Mol Pharm
; 11(6): 1727-38, 2014 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24724562
4.
Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.
Bioorg Med Chem
; 19(1): 650-62, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21093272
5.
Insights for predicting blood-brain barrier penetration of CNS targeted molecules using QSPR approaches.
J Chem Inf Model
; 50(6): 1123-33, 2010 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-20578728
6.
Retrospective assessment of rat liver microsomal stability at NCATS: data and QSAR models.
Sci Rep
; 10(1): 20713, 2020 11 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244000
7.
The Critical Role of Passive Permeability in Designing Successful Drugs.
ChemMedChem
; 15(20): 1862-1874, 2020 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32743945
8.
Identification of a series of benzoxazoles as potent 5-HT6 ligands.
Bioorg Med Chem Lett
; 19(4): 1115-7, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19152787
9.
Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands.
Bioorg Med Chem Lett
; 19(12): 3214-6, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19433358
10.
1-Sulfonylindazoles as potent and selective 5-HT6 ligands.
Bioorg Med Chem Lett
; 19(9): 2413-5, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19345582
11.
Stability challenges in drug discovery.
Chem Biodivers
; 6(11): 1875-86, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19937822
12.
Solution stability--plasma, gastrointestinal, bioassay.
Curr Drug Metab
; 9(9): 860-8, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18991582
13.
In vitro solubility assays in drug discovery.
Curr Drug Metab
; 9(9): 879-85, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18991584
14.
Applications of high throughput microsomal stability assay in drug discovery.
Comb Chem High Throughput Screen
; 11(6): 469-76, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18673274
15.
A regiospecific synthesis of a series of 1-sulfonyl azepinoindoles as potent 5-HT6 ligands.
Bioorg Med Chem Lett
; 18(14): 3929-31, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18583130
16.
Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.
Int J Pharm
; 335(1-2): 1-11, 2007 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17137735
17.
Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples.
J Pharm Biomed Anal
; 44(2): 586-93, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17383138
18.
Quantification of cyclocreatine in mouse and rat plasma using hydrophilic-interaction ultra-performance liquid chromatography-tandem mass spectrometry.
J Pharm Biomed Anal
; 145: 629-633, 2017 Oct 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28800523
19.
Biological assay challenges from compound solubility: strategies for bioassay optimization.
Drug Discov Today
; 11(9-10): 446-51, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16635808
20.
Utility of mass spectrometry for pharmaceutical profiling applications.
Curr Drug Metab
; 7(5): 457-66, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16787155