Detalhe da pesquisa
1.
HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
Cell
; 166(5): 1257-1268.e12, 2016 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27565348
2.
Exploring Residue-Level Interactions between the Biofilm-Driving R2ab Protein and Polystyrene Nanoparticles.
Langmuir
; 40(2): 1213-1222, 2024 01 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38174900
3.
Optimized binding of substituted quinoline ALLINIs within the HIV-1 integrase oligomer.
J Biol Chem
; 296: 100363, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539919
4.
HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
Molecules
; 23(8)2018 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-30049955
5.
Quinolines from the cyclocondensation of isatoic anhydride with ethyl acetoacetate: preparation of ethyl 4-hydroxy-2-methylquinoline-3-carboxylate and derivatives.
Beilstein J Org Chem
; 14: 2529-2536, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344776
6.
A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J Biol Chem
; 291(45): 23569-23577, 2016 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27645997
7.
A new class of multimerization selective inhibitors of HIV-1 integrase.
PLoS Pathog
; 10(5): e1004171, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24874515
8.
HIV-1 integrase multimerization as a therapeutic target.
Curr Top Microbiol Immunol
; 389: 93-119, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25778682
9.
Indole-based allosteric inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 26(19): 4748-4752, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27568085
10.
Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation.
Proc Natl Acad Sci U S A
; 110(21): 8690-5, 2013 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23610442
11.
BET proteins promote efficient murine leukemia virus integration at transcription start sites.
Proc Natl Acad Sci U S A
; 110(29): 12036-41, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818621
12.
A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.
J Biol Chem
; 289(38): 26430-26440, 2014 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25118283
13.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
J Biol Chem
; 288(22): 15813-20, 2013 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-23615903
14.
The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase.
Retrovirology
; 11: 100, 2014 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-25421939
15.
Optimizing the Multimerization Properties of Quinoline-Based Allosteric HIV-1 Integrase Inhibitors.
Viruses
; 16(2)2024 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38399977
16.
Interaction of the HIV-1 intasome with transportin 3 protein (TNPO3 or TRN-SR2).
J Biol Chem
; 287(41): 34044-58, 2012 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22872640
17.
Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors.
J Biol Chem
; 287(20): 16801-11, 2012 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437836
18.
FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.
Nucleic Acids Res
; 39(20): 9009-22, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21771857
19.
Exploring the Residue-Level Interactions between the R2ab Protein and Polystyrene Nanoparticles.
bioRxiv
; 2023 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693402
20.
Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors.
Viruses
; 14(7)2022 07 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35891446