Detalhe da pesquisa
1.
Characterization of Higher Order Structural Changes of a Thermally Stressed Monoclonal Antibody via Mass Spectrometry Footprinting and Other Biophysical Approaches.
Anal Chem
; 95(46): 16840-16849, 2023 11 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37933954
2.
Application of NMR and Chemometric Analyses to Better Understand the Quality Attributes in pH and Thermally Degraded Monoclonal Antibodies.
Pharm Res
; 40(10): 2457-2467, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37798537
3.
Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.
Bioorg Med Chem
; 66: 116820, 2022 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594650
4.
Enabling Efficient Design of Biological Formulations through Advanced Characterizations.
Pharm Res
; 40(6): 1313-1316, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37407877
5.
Observation of untoward 3 Jcc correlations in 1,1-ADEQUATE spectra of pyrimidine analogs: Avoiding potential interpretation pitfalls.
Magn Reson Chem
; 56(8): 775-781, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29603782
6.
Cold denaturation of a protein dimer monitored at atomic resolution.
Nat Chem Biol
; 9(4): 264-70, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396077
7.
Comprehensive characterization of higher order structure changes in methionine oxidized monoclonal antibodies via NMR chemometric analysis and biophysical approaches.
MAbs
; 16(1): 2292688, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38117548
8.
Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.
EMBO J
; 28(20): 3256-68, 2009 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-19745811
9.
HLAII peptide presentation of infliximab increases when complexed with TNF.
Front Immunol
; 13: 932252, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36177046
10.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
11.
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.
J Neurosci
; 30(9): 3184-98, 2010 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20203178
12.
Integrated analysis of the conformation of a protein-linked spin label by crystallography, EPR and NMR spectroscopy.
J Biomol NMR
; 49(2): 111-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21271275
13.
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.
ACS Med Chem Lett
; 12(11): 1678-1688, 2021 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34795856
14.
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.
ACS Med Chem Lett
; 12(9): 1380-1388, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34527178
15.
Novel Applications of Biocatalysis to Stereochemistry Determination of 2'3'-cGAMP Bisphosphorothioate (2'3'-cGSASMP).
ACS Omega
; 5(23): 14173-14179, 2020 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32566885
16.
Automated, High-Throughput Infrared Spectroscopy for Secondary Structure Analysis of Protein Biopharmaceuticals.
J Pharm Sci
; 109(10): 3223-3230, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32758548
17.
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.
ACS Med Chem Lett
; 11(4): 582-588, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292567
18.
Structural properties of pore-forming oligomers of alpha-synuclein.
J Am Chem Soc
; 131(47): 17482-9, 2009 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-19888725
19.
Photoredox Ni-catalyzed peptide C(sp2)-O cross-coupling: from intermolecular reactions to side chain-to-tail macrocyclization.
Chem Sci
; 10(19): 5073-5078, 2019 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31183058
20.
Protecting group free radical C-H trifluoromethylation of peptides.
Chem Sci
; 9(17): 4168-4175, 2018 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29780547