Detalhe da pesquisa
1.
Identification AAVS1-like locus from the porcine genome and site-specific integration of recombinase-mediated cassette exchange using CRISPR/Cas9.
Anim Biotechnol
; 34(9): 4730-4735, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905152
2.
Targeted PMP22 TATA-box editing by CRISPR/Cas9 reduces demyelinating neuropathy of Charcot-Marie-Tooth disease type 1A in mice.
Nucleic Acids Res
; 48(1): 130-140, 2020 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31713617
3.
CRISPR/Cas9-mediated gene knockout screens and target identification via whole-genome sequencing uncover host genes required for picornavirus infection.
J Biol Chem
; 292(25): 10664-10671, 2017 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446605
4.
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells.
Nat Methods
; 12(3): 237-43, 1 p following 243, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25664545
5.
Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation.
Mol Cell
; 31(3): 347-59, 2008 Aug 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-18691967
6.
Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases.
Genome Res
; 22(3): 539-48, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22183967
7.
Generation of knockout mice using engineered nucleases.
Methods
; 69(1): 85-93, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24561165
8.
Disruption of exogenous eGFP gene using RNA-guided endonuclease in bovine transgenic somatic cells.
Zygote
; 23(6): 916-23, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25424059
9.
Production of Mutated Porcine Embryos Using Zinc Finger Nucleases and a Reporter-based Cell Enrichment System.
Asian-Australas J Anim Sci
; 27(3): 324-9, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25049958
10.
Targeted dual base editing with Campylobacter jejuni Cas9 by single AAV-mediated delivery.
Exp Mol Med
; 55(2): 377-384, 2023 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-36720917
11.
Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol.
Cell Death Dis
; 14(7): 474, 2023 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37500624
12.
In vivo genome editing for hemophilia B therapy by the combination of rebalancing and therapeutic gene knockin using a viral and non-viral vector.
Mol Ther Nucleic Acids
; 32: 161-172, 2023 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37064777
13.
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington's disease.
NPJ Regen Med
; 7(1): 8, 2022 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35046408
14.
Genome editing-mediated knock-in of therapeutic genes ameliorates the disease phenotype in a model of hemophilia.
Mol Ther Nucleic Acids
; 29: 551-562, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36090746
15.
In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy.
Sci Adv
; 8(3): eabj6901, 2022 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35061543
16.
Efficient and specific generation of knockout mice using Campylobacter jejuni CRISPR/Cas9 system.
Biochem Biophys Rep
; 22: 100752, 2020 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-32258440
17.
Preassembled zinc-finger arrays for rapid construction of ZFNs.
Nat Methods
; 8(1): 7, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21191366
18.
Mediator modulates Gli3-dependent Sonic hedgehog signaling.
Mol Cell Biol
; 26(23): 8667-82, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17000779
19.
Programmable Nuclease-Based Integration into Novel Extragenic Genomic Safe Harbor Identified from Korean Population-Based CNV Analysis.
Mol Ther Oncolytics
; 14: 253-265, 2019 Sep 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31463366
20.
CRISPR-Cas9-mediated therapeutic editing of Rpe65 ameliorates the disease phenotypes in a mouse model of Leber congenital amaurosis.
Sci Adv
; 5(10): eaax1210, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31692906