Detalhe da pesquisa
1.
Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.
Genes Dev
; 27(11): 1288-98, 2013 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23752590
2.
Design and Construction of a Focused DNA-Encoded Library for Multivalent Chromatin Reader Proteins.
Molecules
; 25(4)2020 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32098353
3.
Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.
Biochemistry
; 57(14): 2140-2149, 2018 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29558110
4.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain.
Nat Chem Biol
; 9(3): 184-91, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23292653
5.
Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1".
Biochemistry
; 57(49): 6806, 2018 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30485080
6.
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells.
Nat Chem Biol
; 7(8): 566-74, 2011 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-21743462
7.
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology.
Alzheimers Dement (N Y)
; 8(1): e12253, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35434254
8.
AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.
Alzheimers Dement (N Y)
; 8(1): e12246, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35475262
9.
Reprogramming CBX8-PRC1 function with a positive allosteric modulator.
Cell Chem Biol
; 29(4): 555-571.e11, 2022 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34715055
10.
Discovery of selective activators of PRC2 mutant EED-I363M.
Sci Rep
; 9(1): 6524, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31024026
11.
Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7.
Cell Chem Biol
; 26(10): 1365-1379.e22, 2019 10 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-31422906
12.
Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.
ACS Chem Biol
; 11(9): 2475-83, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27356154
13.
Small-molecule ligands of methyl-lysine binding proteins: optimization of selectivity for L3MBTL3.
J Med Chem
; 56(18): 7358-71, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24040942
14.
The structure-activity relationships of L3MBTL3 inhibitors: flexibility of the dimer interface.
Medchemcomm
; 4(11): 1501-1507, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24466405
15.
Small-molecule ligands of methyl-lysine binding proteins.
J Med Chem
; 54(7): 2504-11, 2011 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21417280
16.
Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins.
J Biomol Screen
; 15(1): 62-71, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20008125
17.
Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines.
J Med Chem
; 53(15): 5844-57, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-20614940
18.
Discovery of a 2,4-diamino-7-aminoalkoxyquinazoline as a potent and selective inhibitor of histone lysine methyltransferase G9a.
J Med Chem
; 52(24): 7950-3, 2009 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19891491