Detalhe da pesquisa
1.
A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature
; 603(7901): 439-444, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35296845
2.
Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Angew Chem Int Ed Engl
; 63(13): e202316133, 2024 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279624
3.
Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C-H Amination Biocatalysts.
J Am Chem Soc
; 142(23): 10343-10357, 2020 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32407077
4.
Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.
Chembiochem
; 15(7): 1001-10, 2014 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-24692265
5.
Design of an in vitro biocatalytic cascade for the manufacture of islatravir.
Science
; 366(6470): 1255-1259, 2019 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31806816
6.
Enzymatic C(sp3)-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones.
ACS Catal
; 5(3): 1685-1691, 2015 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25954592
7.
Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.
ACS Chem Biol
; 9(1): 164-73, 2014 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-24206617