1.
Bioorg Med Chem Lett
; 23(18): 5070-6, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23937981
RESUMO
A series of N'(1),N'(3)-dialkyl-N'(1),N'(3)-di(alkylcarbonothioyl) malonohydrazides have been designed and synthesized as anticancer agents by targeting oxidative stress and Hsp70 induction. Structure-activity relationship (SAR) studies lead to the discovery of STA-4783 (elesclomol), a novel small molecule that has been evaluated in a number of clinical trials as an anticancer agent in combination with Taxol.