Detalhe da pesquisa
1.
A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy.
Epilepsia
; 59(4): 802-813, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29574705
2.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc Natl Acad Sci U S A
; 110(29): E2724-32, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818614
3.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
4.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorg Med Chem
; 18(22): 7816-25, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965738
5.
Sodium channels and nociception: recent concepts and therapeutic opportunities.
Curr Opin Pharmacol
; 8(1): 50-6, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17964852
6.
The effect of kappa-opioid receptor agonists on tetrodotoxin-resistant sodium channels in primary sensory neurons.
Anesth Analg
; 109(2): 632-40, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19608841
7.
Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain.
J Med Chem
; 51(3): 407-16, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18176998
8.
Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain.
Bioorg Med Chem
; 16(12): 6379-86, 2008 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18501613
9.
Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3.
Eur J Pharmacol
; 435(2-3): 153-60, 2002 Jan 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11821021
10.
An interview with Douglas S. Krafte, Ph.D. Interview by Vicki P. Glaser.
Assay Drug Dev Technol
; 4(1): 1-5, 2006 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-16506884
11.
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats.
Neuropharmacology
; 59(3): 201-7, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20566409
12.
Block of Nav1.8 by small molecules.
Channels (Austin)
; 1(3): 152-3, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18690030
13.
A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.
Proc Natl Acad Sci U S A
; 104(20): 8520-5, 2007 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17483457
14.
Ion channels: applications in ion channel drug discovery.
Comb Chem High Throughput Screen
; 12(1): 1, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19149487
15.
Decrease of inward rectification as a mechanism for arachidonic acid-induced potentiation of hKir2.3.
Eur Biophys J
; 31(7): 497-503, 2002 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-12451419