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Methods to control internal interfaces in lithium ion batteries often require sophisticated procedures to deposit coating layers or introduce interphases, which are typically difficult to apply. This particularly holds for protection from parasitic reactions at the current collector, which reflects an internal interface for the electrode composite material and the electrolyte. In this work, electrolyte formulations based on aliphatic cyclic nitriles, cyclopentane-1-carbonitrile and cyclohexane-1-carbonitrile, are introduced that allow for successful suppression of aluminum dissolution and control of internal interfaces under application-relevant conditions. Such nitrile-based electrolytes show higher intrinsic oxidative and thermal stabilities as well as similar capacity retentions in lithium nickel-manganese-cobalt oxide LiNi3/5Mn1/5Co1/5O2 (NMC622)||graphite based full cells compared to the state-of-the-art organic carbonate-based electrolytes, even when bis(trifluoro-methane)sulfonimide lithium salt is utilized. Moreover, the importance of relative permittivity, degree of ion dissociation, and viscosity of the applied electrolyte formulations for the protection of current collector interfaces is emphasized.
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BACKGROUND AND AIMS: High sodium (Na) and low potassium (K) intake are associated with hypertension and CVD risk. This study explored the associations of health literacy (HL), food literacy (FL), and salt awareness with salt intake, K intake, and Na/K ratio in a workplace intervention trial in Switzerland. METHODS AND RESULTS: The study acquired baseline data from 141 individuals, mean age 44.6 years. Na and K intake were estimated from a single 24-h urine collection. We applied validated instruments to assess HL and FL, and salt awareness. Multiple linear regression was used to investigate the association of explanatory variables with salt intake, K intake, and Na/K. Mean daily salt intake was 8.9 g, K 3.1 g, and Na/K 1.18. Salt intake was associated with sex (p < 0.001), and K intake with sex (p < 0.001), age (p = 0.02), and waist-to-height ratio (p = 0.03), as was Na/K. HL index and FL score were not significantly associated with salt or K intake but the awareness variable "salt content impacts food/menu choice" was associated with salt intake (p = 0.005). CONCLUSION: To achieve the established targets for population Na and K intake, health-related knowledge, abilities, and skills related to Na/salt and K intake need to be promoted through combined educational and structural interventions. Clinical Trials Registry number: DRKS00006790 (23/09/2014).
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Conhecimentos, Atitudes e Prática em Saúde , Letramento em Saúde , Potássio na Dieta/administração & dosagem , Recomendações Nutricionais , Sódio na Dieta/administração & dosagem , Local de Trabalho , Adulto , Biomarcadores/urina , Feminino , Promoção da Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Potássio na Dieta/efeitos adversos , Potássio na Dieta/urina , Medição de Risco , Fatores de Risco , Sódio na Dieta/efeitos adversos , Sódio na Dieta/urina , SuíçaRESUMO
Defects in the biogenesis of peroxisomes cause a clinically and genetically heterogeneous group of neurometabolic disorders, the Zellweger syndrome spectrum (ZSS). Diagnosis predominantly is based on characteristic clinical symptoms, a typical biochemical profile, as well as on identification of the molecular defect in any of the 12 known human PEX genes. The diagnostic workup can be hindered if the typical clinical symptoms are missing and predicting the clinical course of a given patient is almost unfeasible. As a safe and noninvasive method to analyze specific chemical compounds in localized brain regions, in vivo proton magnetic resonance spectroscopy (MRS) can provide an indication in this diagnostic process and may help predict the clinical course. However, to date, there are very few reports on this topic. In this study, we performed localized in vivo proton MRS without confounding contributions from T1- and T2-relaxation effects at 2 Tesla in a comparably large group of seven ZSS patients. Patients' absolute metabolite concentrations in cortical gray matter, white matter, and basal ganglia were assessed and compared with age-matched control values. Our results confirm and extend knowledge about in vivo MRS findings in ZSS patients. Besides affirmation of nonspecific reduction of N-acetylaspartate + N-acetylaspartylglutamate (tNAA) in combination with lipid accumulation as a diagnostic hint for this disease group, the amount of tNAA loss seems to reflect disease burden and may prove to be of prognostic value regarding the clinical course of an already diagnosed patient.
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Síndrome de Zellweger/diagnóstico , Síndrome de Zellweger/patologia , Adolescente , Adulto , Ácido Aspártico/análogos & derivados , Ácido Aspártico/metabolismo , Gânglios da Base/metabolismo , Gânglios da Base/patologia , Criança , Dipeptídeos/metabolismo , Feminino , Substância Cinzenta/metabolismo , Substância Cinzenta/patologia , Humanos , Lactente , Espectroscopia de Ressonância Magnética/métodos , Masculino , Peroxissomos/metabolismo , Peroxissomos/patologia , Prognóstico , Prótons , Substância Branca/metabolismo , Substância Branca/patologia , Adulto Jovem , Síndrome de Zellweger/metabolismoRESUMO
Antinuclear autoantibodies (ANA) are highly informative biomarkers in autoimmune diagnostics. The increasing demand for effective test systems, however, has led to the development of a confusingly large variety of different platforms. One of them, the indirect immunofluorescence (IIF), is regarded as the common gold standard for ANA screening, as described in a position statement by the American College of Rheumatology in 2009. Technological solutions have been developed aimed at standardization and automation of IIF to overcome methodological limitations and subjective bias in IIF interpretation. In this review, we present the EUROPattern Suite, a system for computer-aided immunofluorescence microscopy (CAIFM) including automated acquisition of digital images and evaluation of IIF results. The system was originally designed for ANA diagnostics on human epithelial cells, but its applications have been extended with the latest system update version 1.5 to the analysis of antineutrophil cytoplasmic antibodies (ANCA) and anti-dsDNA antibodies.
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Anticorpos Antinucleares/análise , Sistemas Computacionais , Técnica Indireta de Fluorescência para Anticorpo/métodos , Interpretação de Imagem Assistida por Computador/instrumentação , Microscopia de Fluorescência/métodos , Automação , Biomarcadores , Humanos , Armazenamento e Recuperação da Informação , Padrões de Referência , Reprodutibilidade dos Testes , SoftwareRESUMO
Soluble molecular semiconductors are a promising alternative to semiconducting polymers in the field of organic photovoltaics. Here, three custom-made symmetric 1,3-bis(N,N-alkylated-2,6-dihydroxy-anilino)squaraines containing systematic variations in their molecular structures are compared regarding their applicability as donor materials in bulk-heterojunction solar cells. The terminal substitution pattern of the squaraines is varied from cyclic over linear to branched including a stereogenic center. Single crystal structures are determined, and, in the case of chiral squaraine, unusual formation of stereoisomer co-crystals is revealed. The thin film absorbance spectra show characteristic signatures of H- and J-bands or hint at the formation of tautomers. The general feasibility of these model compounds for photovoltaic applications is studied by light-induced electron spin resonance spectroscopy. The impact of the different molecular substitution patterns on aggregation behavior and, consequently, their optoelectronic solid state properties including charge carrier mobility and finally the solar cell performance are investigated.
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OBJECTIVE: This study evaluated the short term efficacy of tongue cleaning with meridol HALITOSIS tooth & tongue gel in comparison to mechanical tongue cleaning alone and untreated after five and 60 minutes in patients with an oral cause of bad breath. METHODS: Fifty-four male and female subjects with an intra-oral cause of halitosis (organoleptic ratings > or = 2 and volatile sulphur compounds > or = 50 ppb) participated in this crossover study and were assigned to six different treatment sequences (ABC, ACB, BAC, BCA, CAB, CBA) with no treatment (A), mechanical tongue cleaning alone (B), and tongue cleaning with tooth & tongue gel applied to the tongue cleaner (C). Efficacy was assessed by organoleptic ratings and volatile sulphur compound measurements five and 60 minutes after treatment RESULTS: Cleaning the tongue with tooth & tongue gel applied onto the tongue cleaner resulted in significantly reduced organoleptic ratings (p < 0.001 for the five-minute assessment; p = 0.001 for the 60-minute assessment) and volatile sulphur compounds (H2S + CH3SH: p = 0.005 for the five-minute assessment; p = 0.003 for the 60-minute assessment) compared to no treatment at the five- and 60-minute assessment time points, while mechanical tongue cleaning alone was less effective in reducing organoleptic ratings (p = 0.008 for the five-minute assessment; p = 0.144 for the 60-minute assessment) and volatile sulphur compounds (H2S + CH3SH: p = 0.261 for the five-minute assessment; p = 0.365 for the 60-minute assessment). CONCLUSIONS: Single tongue cleaning with meridol HALITOSIS tooth & tongue gel had a positive effect on halitosis five and 60 minutes after treatment. Tongue cleaning with tooth & tongue gel in combination with other oral hygiene procedures is a promising approach to control halitosis.
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Aminas/uso terapêutico , Halitose/prevenção & controle , Higiene Bucal/instrumentação , Fluoretos de Estanho/uso terapêutico , Língua , Cremes Dentais/uso terapêutico , Cromatografia Gasosa , Estudos Cross-Over , Combinação de Medicamentos , Feminino , Halitose/metabolismo , Humanos , Sulfeto de Hidrogênio/análise , Masculino , Pessoa de Meia-Idade , Método Simples-Cego , Compostos de Sulfidrila/análise , Sulfetos/análise , Fatores de Tempo , Língua/efeitos dos fármacos , Resultado do Tratamento , Compostos Orgânicos Voláteis/análiseRESUMO
The NASA InSight Lander on Mars includes the Heat Flow and Physical Properties Package HP3 to measure the surface heat flow of the planet. The package uses temperature sensors that would have been brought to the target depth of 3-5 m by a small penetrator, nicknamed the mole. The mole requiring friction on its hull to balance remaining recoil from its hammer mechanism did not penetrate to the targeted depth. Instead, by precessing about a point midway along its hull, it carved a 7 cm deep and 5-6 cm wide pit and reached a depth of initially 31 cm. The root cause of the failure - as was determined through an extensive, almost two years long campaign - was a lack of friction in an unexpectedly thick cohesive duricrust. During the campaign - described in detail in this paper - the mole penetrated further aided by friction applied using the scoop at the end of the robotic Instrument Deployment Arm and by direct support by the latter. The mole tip finally reached a depth of about 37 cm, bringing the mole back-end 1-2 cm below the surface. It reversed its downward motion twice during attempts to provide friction through pressure on the regolith instead of directly with the scoop to the mole hull. The penetration record of the mole was used to infer mechanical soil parameters such as the penetration resistance of the duricrust of 0.3-0.7 MPa and a penetration resistance of a deeper layer ( > 30 cm depth) of 4.9 ± 0.4 MPa . Using the mole's thermal sensors, thermal conductivity and diffusivity were measured. Applying cone penetration theory, the resistance of the duricrust was used to estimate a cohesion of the latter of 2-15 kPa depending on the internal friction angle of the duricrust. Pushing the scoop with its blade into the surface and chopping off a piece of duricrust provided another estimate of the cohesion of 5.8 kPa. The hammerings of the mole were recorded by the seismometer SEIS and the signals were used to derive P-wave and S-wave velocities representative of the topmost tens of cm of the regolith. Together with the density provided by a thermal conductivity and diffusivity measurement using the mole's thermal sensors, the elastic moduli were calculated from the seismic velocities. Using empirical correlations from terrestrial soil studies between the shear modulus and cohesion, the previous cohesion estimates were found to be consistent with the elastic moduli. The combined data were used to derive a model of the regolith that has an about 20 cm thick duricrust underneath a 1 cm thick unconsolidated layer of sand mixed with dust and above another 10 cm of unconsolidated sand. Underneath the latter, a layer more resistant to penetration and possibly containing debris from a small impact crater is inferred. The thermal conductivity increases from 14 mW/m K to 34 mW/m K through the 1 cm sand/dust layer, keeps the latter value in the duricrust and the sand layer underneath and then increases to 64 mW/m K in the sand/gravel layer below. Supplementary Information: The online version contains supplementary material available at 10.1007/s11214-022-00941-z.
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A dual-mode auto-calibrating resistance thermometer (DART) is presented. The novel DART concept combines in one instrument the fast and accurate resistance thermometry with the primary method of Johnson noise thermometry. Unlike previous approaches, the new thermometer measures the spectral density of the thermal noise in the sensing resistor directly in a sequential measurement procedure without using correlation techniques. A sophisticated data analysis corrects the thermometer output for both the parasitic effects of the sensor wiring and the amplifier current noise. The instrument features a highly linear low-noise DC coupled amplifier with negative feedback as well as an accurate voltage reference and reference resistor to improve the gain stability over time and ambient temperature. Therefore, the system needs only infrequent calibrations with electrical quantum standards and can be operated over long intervals and a wide temperature range without recalibration. A first prototype is designed for the industrially relevant temperature range of the IEC 60751 (-200 °C to +850 °C); a later extension of the measurement range is being considered. A proof-of-principle measurement with a calibrated Pt100 sensor at room temperature yielded an uncertainty of about 100 µK/K. The final device is expected to reach uncertainties of below 10 µK/K, suitable for accurate measurements of the difference between thermodynamic temperatures and temperatures traceable to the International Temperature Scale of 1990 (ITS-90).
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When spilled oil collects at depth, questions as to where and when to dispatch response equipment become daunting, because such oil may be invisible by air, and underwater sensing technology is limited in coverage and by underwater visibility. Further, trajectory modeling based on previously recorded flow field data may show mixed results. In this work, the Bayesian model, SOSim, is modified to locate and forecast the movement of submerged oil, with confidence bound, by inferring model parameters based on any available field concentration data and the output of one or more deterministic trajectory models. Novel aspects include specification of a prior likelihood function, and generation of results in 3-D from data in the 2-D density space of the isopycnal layer containing oil. The model is demonstrated versus data collected following the Deepwater Horizon spill. This new inferential modeling approach appears complimentary to deterministic methods when field concentration data are available.
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Poluição por Petróleo , Teorema de Bayes , Previsões , Golfo do MéxicoRESUMO
Sunken oil is often difficult to detect, and few oil spill models are designed to locate and track such oil. Therefore, the multi-modal Bayesian inferential sunken oil model, SOSim (Subsurface Oil Simulator), was expanded in this work for use during emergency response and damage assessment. Rather than requiring hydrodynamic data as input, SOSim v2 accepts available field concentration data, along with default or custom bathymetric data, for inference of the location and trajectory of sunken oil. Novel aspects include inference based on bathymetry and the Coriolis Effect, by constructing a prior likelihood function from sampled bathymetric data, scaled proportionally with field concentration data. SOSim v2 is demonstrated versus field data on the ITB DBL-152 oil spill in the Gulf of Mexico, with sensitivity analysis. Results suggest that the inferential approach presented can be effective for modeling relatively slow-moving pollutant masses such as sunken oil, when field concentration data are available.
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Poluição por Petróleo , Teorema de Bayes , Golfo do MéxicoRESUMO
One of the important tasks associated with reducing the concentration of contaminants in the sea surface layer is the determination of their mixing volume, as of the most active systems for mixing the sea surface layer are sea vessels. The wake of a ship is a highly mixed medium. The study of the wake development over time is important when evaluating the mixing of various pollutants in the wake with neutralizing chemicals. As shown in some previous works, in the wake of a vessel that crosses a contaminated surface, the concentration of harmful impurities decreases to background values; however, the problem of determining the volumetric characteristics of this wake remains. In our work, we propose a relatively simple model for assessing the characteristics of a turbulent wake in the near zone behind a vessel. Based on the actual parameters of the vessels, the parameter F= (penetration depth) / (draft) was calculated, which characterizes the potential mixing effects caused by turbulence in the wake. The proposed simple model can be used, for example, to assess the mixing of oil when it is being bottled, with chemicals, to assess possible scenarios of increasing its dilution.
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NaviosRESUMO
A rise in the shipping of heavier hydrocarbon products increases the potential for an oil to sink after a spill. Further, sunken oil is difficult to locate and recover, and appropriate response technologies depend on the sinking mechanism. In this review, principal sinking mechanisms for oil are described and appropriate response technologies are suggested. Then, models appropriate for tracking sunken oil are compared. Oil may sink as burn residue, microscopic oil-particle aggregates (OPAs) or macroscopic oil-sediment mixtures (OSMs), marine oil snow during a MOSSFA event, or due to its high density. The most common mechanism is by sediment entrainment, and in such scenarios manual recovery has been reported as a successful response option. Among oil tracking models, trajectory models and Bayesian oil search models are compared for sunken oil capabilities. Many oil spill models require hydrodynamic inputs, whereas Bayesian models infer parameters based on available field concentration and bathymetric data.
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Poluição por Petróleo , Poluentes Químicos da Água , Teorema de Bayes , Sedimentos Geológicos , Hidrocarbonetos , Poluição por Petróleo/análise , Poluentes Químicos da Água/análiseRESUMO
Information is lacking on spray techniques to reduce off-target loss on the ground and via spray drift from the treated area in nursery applications. Airborne deposits at three elevations on sampling towers and on the ground at several distances from the sprayer were investigated with the three spray treatments in an open field without crops. Tests were conducted with an air blast sprayer equipped with conventional hollow cone nozzles (HC), low drift nozzles (AI), and conventional hollow cone nozzles with a drift retardant (HCDR) in an open field without crops. To compare field test results, wind tunnel experiments were conducted to assess spray deposits on the floor beyond 0.4 m downwind distance from the nozzles and airborne deposits at 2.1 m downwind from the spray discharge point with the three spray techniques. Droplet size distributions across spray patterns were measured with a laser particle/droplet image analysis system. There was no significant difference in airborne deposits for the three elevations at both 15 and 30 m downwind from the sprayer between AI and HC methods except for 3.05 m elevation at the 15 m distance although the average airborne deposits with AI were lower than that with HC. The downwind spray deposits on the ground at 15 and 30 m from the sprayer with AI were higher than that with HC and HCDR. Compared with conventional hollow cone nozzles, drift reduction from air induction nozzles or the spray mixture with drift retardant was significant in wind tunnel tests but was not significant in field tests.
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Agricultura/métodos , Modelos Teóricos , Praguicidas , Aerossóis , Poluentes Atmosféricos , Monitoramento Ambiental , VentoRESUMO
We have developed a noise-optimized ultrastable low-noise current amplifier (ULCA) aimed at reducing the uncertainty at low currents. It involves a thin-film resistor network with 6.75 GΩ at the high-ohmic path which reduces the noise level to 1.6 fA/Hz. Noise investigations as well as short-term and long-term stability studies were carried out. The stability of the input current gain was measured using a cryogenic current comparator at ±6.1 nA. Methods for investigating the measurement accuracy at low input currents of about 100 pA at a level of below one part in 107 are introduced and experimentally verified. The performance of the noise-optimized ULCA is compared with that of the standard variant introduced in 2014. It is shown that the reduced noise floor is achieved without impairing the stability of the transresistance.
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As petroleum development and other activities move further north, the potential for oil spills in ice-covered waters is of great concern. As a tool for contingency planning and forecasting during response, oil spill models play a key role. With the development of new, high-resolution coupled ice-ocean models, better predictions of sea ice are becoming available. We have updated the OSCAR oil spill model to use sea-ice velocity and coverage fields from coupled ice-ocean models to improve simulation of oil fate and transport in ice-covered waters. We describe the implementation of oil transport in the presence of ice, and demonstrate the improvement by considering three case studies. We find clear improvement when taking ice velocity from a coupled ice-ocean model into account, compared to a heuristic model that uses surface current and wind velocity. The difference is found to be especially important in a response situation near the marginal ice zone.
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Modelos Teóricos , Poluição por Petróleo/análise , Regiões Árticas , Camada de Gelo , Petróleo/análise , Poluentes Químicos da Água/análise , VentoRESUMO
The near-Earth asteroid (162173) Ryugu is a 900-m-diameter dark object expected to contain primordial material from the solar nebula. The Mobile Asteroid Surface Scout (MASCOT) landed on Ryugu's surface on 3 October 2018. We present images from the MASCOT camera (MASCam) taken during the descent and while on the surface. The surface is covered by decimeter- to meter-sized rocks, with no deposits of fine-grained material. Rocks appear either bright, with smooth faces and sharp edges, or dark, with a cauliflower-like, crumbly surface. Close-up images of a rock of the latter type reveal a dark matrix with small, bright, spectrally different inclusions, implying that it did not experience extensive aqueous alteration. The inclusions appear similar to those in carbonaceous chondrite meteorites.
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The prognosis of high-risk Ewing tumours (HR-ET) remains poor. Melphalan-containing chemotherapy regimens are commonly applied for HR-ET patients. Moreover, melphalan (Mel) is a promising agent in thermochemotherapy. Therefore, we investigated the single effects, the synergism and the gene regulation of Mel and hyperthermia (HT) in an ET cell line (RD-ES). Dose-dependent cytotoxicity by Mel was demonstrated, which was enhanced by the concomitant application of HT (42 degrees C for 2 h). Mel, HT and their combination caused a significant activation of caspase-3. Using the pan-caspase inhibitor z-VAD-fmk, we demonstrated that both stimuli mediated predominantly caspase-dependent cytotoxicity. With cDNA array analysis, 20 out of 198 apoptosis-related genes were identified to be differentially expressed by Mel and/or HT. Although a significant enhancement of three selected genes could not be proven at the protein level in subsequent experiments, this study gives insight into the complex molecular and genetic response of tumour cells to cytotoxic stimulation.
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Antineoplásicos Alquilantes/farmacologia , Regulação Neoplásica da Expressão Gênica , Hipertermia Induzida , Melfalan/farmacologia , Sarcoma de Ewing/genética , Sarcoma de Ewing/terapia , Ligante 4-1BB/antagonistas & inibidores , Ligante 4-1BB/metabolismo , Apoptose/efeitos dos fármacos , Apoptose/genética , Apoptose/fisiologia , Proteínas Reguladoras de Apoptose/antagonistas & inibidores , Proteínas Reguladoras de Apoptose/biossíntese , Proteínas Reguladoras de Apoptose/genética , Caspase 3/metabolismo , Linhagem Celular Tumoral , Terapia Combinada , Relação Dose-Resposta a Droga , Ativação Enzimática , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Humanos , Masculino , Proteínas Serina-Treonina Quinases/antagonistas & inibidores , Proteínas Serina-Treonina Quinases/biossíntese , Proteínas Serina-Treonina Quinases/genética , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/antagonistas & inibidores , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/biossíntese , Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética , Sarcoma de Ewing/patologia , Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/antagonistas & inibidores , Membro 9 da Superfamília de Receptores de Fatores de Necrose Tumoral/metabolismo , Adulto JovemRESUMO
Understanding the evaporation of pesticide droplets and wetting of Leaf surfaces can increase foliar application efficiency and reduce pesticide use. Evaporation time and wetted area of single pesticide droplets on hairy and waxy geranium leaf surfaces were measured under the controlled conditions for five droplet sizes and three relative humidities. The sprays used to form droplets included water, a nonionic colloidal polymer drift retardant, an alkyl polyoxyethylene surfactant, and an insecticide. Adding the surfactant into spray mixtures greatly increased droplet wetted area on the surfaces while droplet evaporation time was greatly reduced. Adding the drift retardant into spray mixture slightly increased the droplet evaporation time and the wetted area. Also, droplets had Longer evaporation times on waxy leaves than on hairy leaves for all droplet diameters and all relative humidity conditions. Increasing relative humidity could increase the droplet evaporation time greatly but did not change the the wetted area. The droplet evaporation time and wetted area increased exponentially as the droplet size increased. Therefore, droplet size, surface characteristics of the target, relative humidity, and chemical composition of the spray mixtures (water alone, pesticide, additives) should be included as important factors that affect the efficacy and efficiency of pesticide applications.
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Geranium/química , Praguicidas/análise , Folhas de Planta/química , Tensoativos/análise , Fenômenos Biofísicos , Umidade , Tamanho da Partícula , Transição de Fase , Propriedades de Superfície , Tensoativos/química , Fatores de Tempo , Água/química , MolhabilidadeRESUMO
Natural marine snow (NMS) is defined as the "shower" of particle aggregates formed by processes that occur in the world's oceans, consisting of macroscopic aggregates of detritus, living organisms and inorganic matter. Recent studies from the Deepwater Horizon oil spill suggest that marine snow is also formed in association with oil spills and was an important factor for the transport of oil to the seabed. This review summarizes the research and literature on MS, mainly from the DWH oil spill, with a focus on the relation between the use of oil spill dispersants and the formation and fate of oil-related marine snow (ORMS). Studies are still required to determine ORMS processes at oil concentrations as relevant as possible for chemically dispersed oil.