Detalhe da pesquisa
1.
Overexpression and RNAi-mediated Knockdown of Two 3ß-hydroxy-Δ5-steroid dehydrogenase Genes in Digitalis lanata Shoot Cultures Reveal Their Role in Cardenolide Biosynthesis.
Planta Med
; 89(8): 833-847, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37187191
2.
Effects of Lipophilicity and Structural Features on the Antiherpes Activity of Digitalis Cardenolides and Derivatives.
Chem Biodivers
; 19(10): e202200411, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36085355
3.
Cytotoxicity of glucoevatromonoside alone and in combination with chemotherapy drugs and their effects on Na+,K+-ATPase and ion channels on lung cancer cells.
Mol Cell Biochem
; 476(4): 1825-1848, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33459980
4.
RNAi-mediated gene knockdown of progesterone 5ß-reductases in Digitalis lanata reduces 5ß-cardenolide content.
Plant Cell Rep
; 40(9): 1631-1646, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34146141
5.
Investigation of the cytotoxic activity of two novel digitoxigenin analogues on H460 lung cancer cells.
Anticancer Drugs
; 31(5): 452-462, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32079825
6.
Elucidation of the mechanism of anti-herpes action of two novel semisynthetic cardenolide derivatives.
Arch Virol
; 165(6): 1385-1396, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32346764
7.
Semisynthetic Cardenolides Acting as Antiviral Inhibitors of Influenza A Virus Replication by Preventing Polymerase Complex Formation.
Molecules
; 25(20)2020 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33096707
8.
Exploiting enzyme promiscuity to shape plant specialized metabolism.
J Exp Bot
; 70(5): 1435-1445, 2019 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30715457
9.
Cytotoxic effects of the cardenolide convallatoxin and its Na,K-ATPase regulation.
Mol Cell Biochem
; 428(1-2): 23-39, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28176244
10.
The Foxgloves (Digitalis) Revisited.
Planta Med
; 83(12-13): 962-976, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28561136
11.
Production of the Cytotoxic Cardenolide Glucoevatromonoside by Semisynthesis and Biotransformation of Evatromonoside by a Digitalis lanata Cell Culture.
Planta Med
; 83(12-13): 1035-1043, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28486743
12.
Three-Step Test System for the Identification of Novel GABAA Receptor Modulating Food Plants.
Plant Foods Hum Nutr
; 71(4): 355-360, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27392961
13.
Knockout of Arabidopsis thaliana VEP1, Encoding a PRISE (Progesterone 5ß-Reductase/Iridoid Synthase-Like Enzyme), Leads to Metabolic Changes in Response to Exogenous Methyl Vinyl Ketone (MVK).
Metabolites
; 12(1)2021 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35050133
14.
21-Hydroxypregnane 21-O-malonylation, a crucial step in cardenolide biosynthesis, can be achieved by substrate-promiscuous BAHD-type phenolic glucoside malonyltransferases from Arabidopsis thaliana and homolog proteins from Digitalis lanata.
Phytochemistry
; 187: 112710, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33930670
15.
Expression of 3beta-HSD and P5betaR, genes respectively coding for Delta5-3beta-hydroxysteroid dehydrogenase and progesterone 5beta-reductase, in leaves and cell cultures of Digitalis lanata EHRH.
Planta Med
; 76(9): 923-7, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20514608
16.
Immobilization of flavonol 3-O-beta-heterodisaccharidase on porous glass and production of rutinose from rutin.
Planta Med
; 75(13): 1459-61, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19452439
17.
Biosynthetic approach to combine the first steps of cardenolide formation in Saccharomyces cerevisiae.
Microbiologyopen
; 8(12): e925, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31436030
18.
Potential anti-herpes and cytotoxic action of novel semisynthetic digitoxigenin-derivatives.
Eur J Med Chem
; 167: 546-561, 2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30798081
19.
Purification and characterization of malonyl-coenzyme A: 21-hydroxypregnane 21-O-malonyltransferase (Dp21MaT) from leaves of Digitalis purpurea L.
Phytochemistry
; 69(3): 619-26, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17945319
20.
A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis.
Steroids
; 73(4): 458-65, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18249427