Detalhe da pesquisa
1.
A Hybrid Structure-Based Machine Learning Approach for Predicting Kinase Inhibition by Small Molecules.
J Chem Inf Model
; 63(17): 5457-5472, 2023 09 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-37595065
2.
Cyp1 Inhibition Prevents Doxorubicin-Induced Cardiomyopathy in a Zebrafish Heart-Failure Model.
Chembiochem
; 21(13): 1905-1910, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32003101
3.
Representing high throughput expression profiles via perturbation barcodes reveals compound targets.
PLoS Comput Biol
; 13(2): e1005335, 2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28182661
4.
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.
Angew Chem Int Ed Engl
; 55(44): 13714-13718, 2016 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-27690172
5.
Stitched α-helical peptides via bis ring-closing metathesis.
J Am Chem Soc
; 136(35): 12314-22, 2014 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25105213
6.
Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery.
J Cheminform
; 16(1): 33, 2024 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38515171
7.
Enhancing the Small-Scale Screenable Biological Space beyond Known Chemogenomics Libraries with Gray Chemical MatterâCompounds with Novel Mechanisms from High-Throughput Screening Profiles.
ACS Chem Biol
; 19(4): 938-952, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38565185
8.
Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2'-OMe RNA-interacting polynucleotide (RIPtide) microarrays.
J Biol Chem
; 287(22): 18843-53, 2012 May 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-22451672
9.
Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1.
J Biol Chem
; 287(30): 24916-28, 2012 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-22511791
10.
Structure of the stapled p53 peptide bound to Mdm2.
J Am Chem Soc
; 134(1): 103-6, 2012 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-22148351
11.
Chemotography for multi-target SAR analysis in the context of biological pathways.
Bioorg Med Chem
; 20(18): 5416-27, 2012 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22405595
12.
Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
ACS Med Chem Lett
; 12(1): 99-106, 2021 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33488970
13.
Correction to "Stitched α-Helical Peptides via Bis Ring-Closing Metathesis".
J Am Chem Soc
; 137(27): 8858, 2015 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26134449
14.
Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space.
SLAS Discov
; 25(4): 384-396, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31701793
15.
Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis.
Cell Rep Med
; 1(4): 100056, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205063
16.
All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.
J Am Chem Soc
; 131(13): 4622-7, 2009 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-19334772
17.
CHEMGENIE: integration of chemogenomics data for applications in chemical biology.
Drug Discov Today
; 23(1): 151-160, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28917822
18.
Iterative Focused Screening with Biological Fingerprints Identifies Selective Asc-1 Inhibitors Distinct from Traditional High Throughput Screening.
ACS Chem Biol
; 12(2): 519-527, 2017 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28032990
19.
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.
ACS Chem Biol
; 12(9): 2448-2456, 2017 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28806050
20.
Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.
SLAS Discov
; 22(8): 995-1006, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28426940