Detalhe da pesquisa
1.
Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.
Bioorg Med Chem Lett
; 84: 129193, 2023 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36822300
2.
High-Throughput Bioassays using "Dip-and-Go" Multiplexed Electrospray Mass Spectrometry.
Angew Chem Int Ed Engl
; 58(49): 17594-17598, 2019 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31589796
3.
Discovery of potent iminoheterocycle BACE1 inhibitors.
Bioorg Med Chem Lett
; 24(23): 5455-9, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455483
4.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
5.
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Bioorg Med Chem Lett
; 20(9): 2837-42, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347593
6.
Overcoming Time-Dependent Inhibition (TDI) of Cytochrome P450 3A4 (CYP3A4) Resulting from Bioactivation of a Fluoropyrimidine Moiety.
J Med Chem
; 61(23): 10700-10708, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388368
7.
Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity.
J Med Chem
; 60(7): 2983-2992, 2017 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28245354
8.
The BACE1 inhibitor verubecestat (MK-8931) reduces CNS ß-amyloid in animal models and in Alzheimer's disease patients.
Sci Transl Med
; 8(363): 363ra150, 2016 11 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27807285
9.
TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Sci Transl Med
; 8(329): 329ra32, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26962156
10.
Structure-Based Design of an Iminoheterocyclic ß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
J Med Chem
; 59(7): 3231-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937601
11.
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(23): 10435-10450, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933948
12.
Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
Biochem J
; 380(Pt 2): 425-33, 2004 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14992689
13.
Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s).
Biochem Pharmacol
; 68(5): 867-73, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15294449
14.
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aß Reduction.
ACS Med Chem Lett
; 3(11): 897-902, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23412139
15.
Design and validation of bicyclic iminopyrimidinones as beta amyloid cleaving enzyme-1 (BACE1) inhibitors: conformational constraint to favor a bioactive conformation.
J Med Chem
; 55(21): 9331-45, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989333
16.
Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation.
J Med Chem
; 53(3): 951-65, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20043696