1.
Bioorg Med Chem
; 13(24): 6629-44, 2005 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16216515
RESUMO
Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated >50% inhibition of bovine cartilage degradation at 10 ng/mL.