Children's judgments of and reasoning about people with disabilities who produce norm violations.

People with disabilities may behave in non-normative ways because they cannot act otherwise. This study explored whether U.S. children aged 3.00 to 8.99 years (N = 105) differ in their evaluations of people who commit norm violations when those persons have perceptual or physical disabilities. Across 12 scenarios, children were asked to explain different characters' non-normative behaviors and to evaluate each character's naughtiness. Characters were typically developing, had a physical disability, or had a hearing disability. Disabilities were described to participants but were not visually depicted. Across moral and conventional norm violations, children aged 4.5 years and older judged characters with disabilities as less naughty than characters without disabilities, whereas younger children (3 and 4 years) judged all characters as equally naughty. Children's explanations for characters' non-normative behaviors (acknowledging characters' physical/auditory limitations and inferring negative attributes) significantly predicted their naughtiness judgments; this was true for participants across the sampled age range. Thus, preschool children demonstrated flexibility in their moral judgments across a variety of everyday behavioral violations, tempering their negative evaluations of persons who committed non-normative behaviors when those persons had unseen disabilities that could reasonably account for their actions. Parents and teachers may be able to build on these early moral intuitions to foster greater acceptance of persons with disabilities.

Overhearing Brief Negative Messages Has Lasting Effects on Children's Attitudes Toward Novel Social Groups.

Societies are rife with out-group discrimination and mistreatment. One way that children might acquire social biases that lead to such outcomes is by overhearing derogatory or disparaging comments about social groups. Children (n = 121) overheard a video call between a researcher and an adult or child caller who made negative claims (or no claims) about a novel social group. Immediately and following a 2-week delay, older children (7-9 years) who overheard the message demonstrated stronger negative attitudes toward the group than children who heard no message. Younger children's (4- to 5-year-olds') attitudes were generally unaffected by these claims. Thus, overhearing brief, indirect messages from children or adults had robust and lasting effects on the social biases of children 7 years and older.

Australian military and veterans' mental health care: improving assessment of military personnel and veterans.

OBJECTIVE: To describe key practical knowledge and skill components required for clinicians involved with the assessment of military personnel and veterans. CONCLUSIONS: Assessment of military and veterans' mental health issues involves a tailored history-taking process that includes specific aspects of service, transition and reporting requirements. Recommendations for the detailed assessment of military personnel and veterans are provided. Comorbid conditions, chronic pain and the needs of both women and older veterans are also discussed.

The Influence of Direct and Overheard Messages on Children's Attitudes Toward Novel Social Groups.

Individuals often develop negative biases toward unfamiliar or denigrated groups. Two experimental studies were conducted to investigate the extent to which brief negative messages about novel social groups influence children's (4- to 9-year-olds'; N = 153) intergroup attitudes. The studies examined the relative influence of messages that are provided directly to children versus messages that are overheard and examined whether the force of these messages varies with children's age. According to implicit and explicit measures of children's intergroup attitudes, children rapidly internalized messages demeaning novel groups, thus forming negative attitudes toward outgroups merely on the basis of hearsay. These effects were generally stronger among older children, and were particularly pronounced when the message was provided directly to children.

Children's belief in purported events: When claims reference hearsay, books, or the internet.

Children aged 4.75-8.50 years (n = 127) heard testimony about improbable or impossible events-referencing either spoken hearsay, a book, or the internet-and judged whether the events could occur in reality. A separate baseline group (n = 48) judged the events without hearing testimony. Relative to baseline, younger children (4 and 5 years) reported greater belief that improbable events could occur when testimony referenced hearsay and less belief when testimony referenced the internet. In contrast, older children (8 years) were less likely to believe improbable events could occur when testimony referenced hearsay and believed testimony that referenced a text-based source (a book or the internet) at rates similar to baseline. Beliefs about the occurrence of impossible events were similar (and low) across ages and testimony conditions. Implications for children's learning from spoken and text-based sources are discussed.

Australian military and veteran's mental health care part 1: an introduction to cultural essentials for clinicians.

OBJECTIVE: This article aims to define the cultural specificity of Australian military and veterans, and introduce some of the essential clinician knowledge, skills and attitudes required for effective cultural competence in the management of mental health (MH) conditions in this population. CONCLUSION: Military culture has the defining characteristics of the military as an organisation with a formal structure, as a cultural group governed by norms and shared values, and as a social group that provides people with identities. Key requirements for cultural competence introduced here are basic knowledge of the military structure, norms and identity; clinical skills including basic assessment and awareness of the commonly occurring MH disorders; and an exploration of attitudes of both the clinician and the military or veteran patient. Further research is needed, particularly in terms of assessing clinician's cultural competence.

Bovine colostrum-driven modulation of intestinal epithelial cells for increased commensal colonisation.

Nutritional intake may influence the intestinal epithelial glycome and in turn the available attachment sites for bacteria. In this study, we tested the hypothesis that bovine colostrum may influence the intestinal cell surface and in turn the attachment of commensal organisms. Human HT-29 intestinal cells were exposed to a bovine colostrum fraction (BCF) rich in free oligosaccharides. The adherence of several commensal bacteria, comprising mainly bifidobacteria, to the intestinal cells was significantly enhanced (up to 52-fold) for all strains tested which spanned species that are found across the human lifespan. Importantly, the changes to the HT-29 cell surface did not support enhanced adhesion of the enteric pathogens tested. The gene expression profile of the HT-29 cells following treatment with the BCF was evaluated by microarray analysis. Many so called "glyco-genes" (glycosyltransferases and genes involved in the complex biosynthetic pathways of glycans) were found to be differentially regulated suggesting modulation of the enzymatic addition of sugars to glycoconjugate proteins. The microarray data was further validated by means of real-time PCR. The current findings provide an insight into how commensal microorganisms colonise the human gut and highlight the potential of colostrum and milk components as functional ingredients that can potentially increase commensal numbers in individuals with lower counts of health-promoting bacteria.

Children's and adults' epistemic trust in and impressions of inaccurate informants.

As children and adults interact with new individuals, they make and revise inferences about these individuals' traits and intentions; they build and refine psychological profiles. Here, we examined how this ability develops during early childhood and manifests during adulthood by focusing on the construction of psychological profiles for individuals who have repeatedly provided inaccurate information. Children aged 4-7 years (n = 66) and adults (n = 62) played six rounds of a game in which they needed to find a hidden sticker. In each round, an informant made a claim about the sticker's location, and then participants guessed the sticker's location. In each round, after participants guessed, it was revealed that the informant's claim was incorrect. Across trials, children and adults quickly lost trust in the informant's claims. Children's impressions of the informant's smartness, niceness, and intentions became slightly more negative across trials. In contrast, adults' impressions of the informant's smartness increased, whereas their impressions of the informant's niceness decreased, and adults nearly unanimously judged the informant to be purposely (rather than mistakenly) inaccurate. In sum, children and adults track the accuracy of an informant over time and use this information to update their epistemic trust in the informant. However, based on the same data, children and adults end up with different interpretations of the informant's psychological characteristics-her traits and intentions.

Quality assurance of Cyberknife robotic stereotactic radiosurgery using an angularly independent silicon detector.

PURPOSE: The aim of this work was to evaluate the use of an angularly independent silicon detector (edgeless diodes) developed for dosimetry in megavoltage radiotherapy for Cyberknife in a phantom and for patient quality assurance (QA). METHOD: The characterization of the edgeless diodes has been performed on Cyberknife with fixed and IRIS collimators. The edgeless diode probes were tested in terms of basic QA parameters such as measurements of tissue-phantom ratio (TPR), output factor and off-axis ratio. The measurements were performed in both water and water-equivalent phantoms. In addition, three patient-specific plans have been delivered to a lung phantom with and without motion and dose measurements have been performed to verify the ability of the diodes to work as patient-specific QA devices. The data obtained by the edgeless diodes have been compared to PTW 60016, SN edge, PinPoint ionization chamber, Gafchromic EBT3 film, and treatment planning system (TPS). RESULTS: The TPR measurement performed by the edgeless diodes show agreement within 2.2% with data obtained with PTW 60016 diode for all the field sizes. Output factor agrees within 2.6% with that measured by SN EDGE diodes corrected for their field size dependence. The beam profiles' measurements of edgeless diodes match SN EDGE diodes with a measured full width half maximum (FWHM) within 2.3% and penumbra widths within 0.148 mm. Patient-specific QA measurements demonstrate an agreement within 4.72% in comparison with TPS. CONCLUSION: The edgeless diodes have been proved to be an excellent candidate for machine and patient QA for Cyberknife reproducing commercial dosimetry device measurements without need of angular dependence corrections. However, further investigation is required to evaluate the effect of their dose rate dependence on complex brain cancer dose verification.

Preschoolers Continually Adjust Their Epistemic Trust Based on an Informant's Ongoing Accuracy.

Children aged 4-7 years (N = 120) played four rounds of a find-the-sticker game. For each round, an informant looked into two cups and made a claim about which cup held a sticker. At the end of each round, children guessed the sticker's location, and then the sticker's actual location was revealed. For three of the rounds, the informant accurately reported the sticker's location. But critically, for one round-either Round 1, 2, or 3-she was inaccurate. Children continually adjusted their trust in the informant as they obtained more information about her accuracy. Relations between the informant's pattern of accuracy and children's trust were robust, neither mediated nor moderated by children inferences about her intent or traits.

The Influence of First-Hand Testimony and Hearsay on Children's Belief in the Improbable.

Children (3.5-8.5 years; n = 105) heard claims about the occurrence of improbable or impossible events, then were asked whether the events could really happen. Some claims were based on informants' first-hand observations and others were hearsay. A baseline group (n = 56) reported their beliefs about these events without hearing testimony. Neither first-hand claims nor hearsay influenced beliefs about impossible events, which remained low across the age range. Hearsay (but not first-hand claims) did influence beliefs about improbable events. Preschoolers expressed greater belief following hearsay, compared to their beliefs following first-hand claims and compared to the baseline group's beliefs. By contrast, older children expressed less belief following hearsay, compared to their beliefs following first-hand claims and compared to the baseline group's beliefs.

Revisiting the famous farm foxes: A psychological perspective.

Five decades ago, Dmitry Belyaev, Lyudmila Trut, and colleagues began a now-famous experiment, selectively breeding foxes based on one criterion: perceived tame behavior. Over generations, the fox population changed in behavior (as predicted) but, intriguingly, also changed markedly in appearance-for example, many had wider mouths, curlier tails, different fur coloring, and floppy ears. These researchers concluded that the morphological changes that appeared in their foxes were a by-product of the researchers' selecting for genetic variants that are implicated both in behavior and in appearance. For decades, scientists have largely accepted this "shared genetic variants" interpretation to fully account for the co-occurrence of behavioral and morphological phenotypes in these foxes and in other domesticated animals. However, several decades of psychological research on human social cognition, human-canine interaction, and canine behavior strongly suggest that such an account may be incomplete. I forward a supplementary perspective, based on psychological research, that the covariation of appearance and behavior among these foxes may be partly an artifact of human psychological processes at play in selection. These processes include humans' tendency to infer individuals' traits based on their physical features; trait inferences, in turn, influence how humans treat those individuals. If accurate, this account bears on our understanding of these famous foxes, human-canine interactions, as well as humans' role in domestication.

CyberKnife® fixed cone and Iris™ defined small radiation fields: Assessment with a high-resolution solid-state detector array.

PURPOSE: The challenges of accurate dosimetry for stereotactic radiotherapy (SRT) with small unflattened radiation fields have been widely reported in the literature. In this case, suitable dosimeters would have to offer a submillimeter spatial resolution. The CyberKnife® (Accuray Inc., Sunnyvale, CA, USA) is an SRT-dedicated linear accelerator (linac), which can deliver treatments with submillimeter positional accuracy using circular fields. Beams are delivered with the desired field size using fixed cones, the InCise™ multileaf collimator or a dynamic variable-aperture Iris™ collimator. The latter, allowing for field sizes to be varied during treatment delivery, has the potential to decrease treatment time, but its reproducibility in terms of output factors (OFs) and dose profiles (DPs) needs to be verified. METHODS: A 2D monolithic silicon array detector, the "Octa", was evaluated for dosimetric quality assurance (QA) for a CyberKnife system. OFs, DPs, percentage depth-dose (PDD) and tissue maximum ratio (TMR) were investigated, and results were benchmarked against the PTW SRS diode. Cross-plane, in-plane and 2 diagonal dose profiles were measured simultaneously with high spatial resolution (0.3 mm). Monte Carlo (MC) simulations with a GEANT4 (GEometry ANd Tracking 4) tool-kit were added to the study to support the experimental characterization of the detector response. RESULTS: For fixed cones and the Iris, for all field sizes investigated in the range between 5 and 60 mm diameter, OFs, PDDs, TMRs, and DPs in terms of FWHM measured by the Octa were accurate within 3% when benchmarked against the SRS diode and MC calculations. CONCLUSIONS: The Octa was shown to be an accurate dosimeter for measurements with a 6 MV FFF beam delivered with a CyberKnife system. The detector enabled real-time dosimetric verification for the variable aperture Iris collimator, yielding OFs and DPs consistent with those obtained with alternative methods.

Young children's attributions of causal power to novel invisible entities.

In two studies, we investigated the development of children's reasoning about potent invisible entities. In Study 1, children aged 2.2-5.5years (N=48) were briefly told about a novel invisible substance that could produce a novel outcome-make a novel box turn green. During this introduction, children watched as one container was inverted over a box and the box lit up green, and then another identical container was inverted over the box and the box did not light up. On test trials, the experimenter inserted a spoon in novel (actually empty) containers and inverted the spoon over the box, which turned green in one trial and did not light up in the other trial. For both trials, children were asked whether there was anything in each container. Children across this age range appropriately reported that an invisible substance was present only when the box lit up. In Study 2, children aged 2.4-4.5years (N=48) watched similar demonstrations but were not explicitly provided information about the invisible substance. Children as young as 3years spontaneously inferred that an invisible substance was present when the box lit up and was absent when the box did not light up. A final task tested children's ability to use their causal knowledge of invisible substances to produce an effect-making the box light up. The youngest children had difficulty with this task, but many children aged 3.5-4.5years performed capably. These results indicate an early-emerging understanding of potent invisible entities that develops rapidly during early childhood.

The impact of counter-perceptual testimony on children's categorization after a delay.

When preschoolers are presented with a label for an entity that conflicts with its appearance, they sometimes rely on the new label rather than on the entity's appearance to categorize the entity and to infer its properties. We examined whether children's learning from such claims is short-lived or long-lasting and whether the persistence of their learning depends on the degree of fit between those claims and the available perceptual evidence. Children aged 3-5years (N=71) were asked to categorize hybrids. These hybrids combined 75% of the features from one animal or object with 25% of the features from a different animal or object. After categorizing each hybrid, children heard an informant provide a contrary label. Immediately after they were provided with this new label, children often recategorized the entities accordingly, especially when the label matched the hybrid's predominant features. Children's endorsement of the informant's label proved to be long-lasting when it matched the hybrid's predominant features, typically persisting even after 5weeks. In contrast, children's endorsement often faded over time when the informant's label did not match the hybrid's predominant features. Overall, children were more skeptical of testimony that was more discrepant with the perceptual evidence available to them, and they were less likely to continue endorsing it after a delay. The findings have implications for our understanding of how children eventually come to represent and believe in counter-perceptual and counterintuitive concepts.

Infection-Related Death among Persons with Refractory Juvenile Idiopathic Arthritis.

Severe infections are emerging as major risk factors for death among children with juvenile idiopathic arthritis (JIA). In particular, children with refractory JIA treated with long-term, multiple, and often combined immunosuppressive and antiinflammatory agents, including the new biological disease-modifying antirheumatic drugs (DMARDs), are at increased risk for severe infections and death. We investigated 4 persons with JIA who died during 1994-2013, three of overwhelming central venous catheter-related bacterial sepsis caused by coagulase-negative Staphylococus or α-hemolytic Streptococcus infection and 1 of disseminated adenovirus and Epstein-Barr virus infection). All 4 had active JIA refractory to long-term therapy with multiple and combined conventional and biological DMARDs. Two died while receiving high-dose systemic corticosteroids, methotrexate, and after recent exposure to anti-tumor necrosis factor-α biological DMARDs, and 2 during hematopoietic stem cell transplantation procedure. Reporting all cases of severe infections and especially deaths in these children is of paramount importance for accurate surveillance.

The Role of Oligosaccharides in Host-Microbial Interactions for Human Health.

Milk oligosaccharides have many associated bioactivities which can contribute to human health and offer protective properties to the host. Such bioactivities include anti-infective properties whereby oligosaccharides interact with bacterial cells and prevent adhesion to the host and subsequent colonization. Milk oligosaccharides have also been shown to alter the glycosylation of intestinal cells, leading to a reduction in pathogenic colonization. In addition, these sugars promote adhesion of commensal bacterial strains to host cells as well as possessing the ability to alter mucin expression in intestinal cells and improve barrier function. The ability of milk oligosaccharides to alter the transcriptome of both commensal bacterial strains and intestinal epithelial cells has also been revealed, indicating the potential of many cell types to detect the presence of milk oligosaccharides and respond accordingly at the genetic level. Interestingly, domestic animal milk may provide a bioactive source of oligosaccharides for formula supplementation with the aim of emulating the gold standard that is human milk. Overall, this review highlights the ability of milk oligosaccharides to promote health in a variety of ways, for example, through direct bacterial interactions, immunomodulatory activities, promotion of gut barrier function, and induction of protective transcriptional responses.

Aggression, Sibling Antagonism, and Theory of Mind During the First Year of Siblinghood: A Developmental Cascade Model.

A developmental cascade model was tested to examine longitudinal associations among firstborn children's aggression, theory of mind (ToM), and antagonism toward their younger sibling during the 1st year of siblinghood. Aggression and ToM were assessed before the birth of a sibling and 4 and 12 months after the birth, and antagonism was examined at 4 and 12 months in a sample of 208 firstborn children (initial Mage  = 30 months, 56% girls) from primarily European American, middle-class families. Firstborns' aggression consistently predicted high sibling antagonism both directly and through poorer ToM. Results highlight the importance of examining longitudinal influences across behavioral, social-cognitive, and relational factors that are closely intertwined even from the early years of life.

The Roles of Intuition and Informants' Expertise in Children's Epistemic Trust.

This study examined how children's intuitions and informants' expertise influence children's trust in informants' claims. Three- to 8-year-olds (N = 192) watched videos in which experts (animal/biology experts or artifact/physics experts) made either intuitively plausible or counterintuitive claims about obscure animals or artifacts. Claims fell either within or beyond experts' domains of expertise. Children of all ages were more trusting of claims made by informants with relevant, as opposed to irrelevant, expertise. Children also showed greater acceptance of intuitive rather than counterintuitive claims, a differentiation that increased with age as they developed firmer intuitions about what can ordinarily happen. In summary, children's trust in testimony depends on whether informants have the relevant expertise as well as on children's own developing intuitions.

Low-dose serotherapy improves early immune reconstitution after cord blood transplantation for primary immunodeficiencies.

Cord blood transplantation (CBT) is curative for many primary immunodeficiencies (PIDs) but is associated with risks of viral infection and graft-versus-host disease (GvHD). Serotherapy reduces GvHD but potentially increases the risk of viral infection by delaying immune reconstitution. Because many PID patients have pre-existing viral infections, the optimal dose of serotherapy is unclear. We performed a retrospective analysis in 34 consecutive PID patients undergoing CBT and compared immune reconstitution, viral infection, GvHD, mortality, and long-term immune function between high-dose (n = 11) and low-dose (n = 9) serotherapy. Serotherapy dose had no effect on neutrophil engraftment. Median CD3(+) engraftment occurred at 92.5 and 97 days for high- and low-dose serotherapy, respectively. The low-dose serotherapy group had higher CD3(+), CD4(+), and early thymic emigrant counts at 4 months compared with the high-dose group. GvHD severity and number of viral infections did not differ between serotherapy doses. Survival from the transplantation process was 90.9% for high-dose and 100% for low-dose groups. In conclusion, low-dose serotherapy enhanced T cell reconstitution and thymopoiesis during the first year after CBT with no increase in GvHD.