Detalhe da pesquisa
1.
PKPD modeling of acquired resistance to anti-cancer drug treatment.
J Pharmacokinet Pharmacodyn
; 44(6): 617-630, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29090407
2.
Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs.
Pharm Res
; 33(5): 1115-25, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26786016
3.
Translational PK/PD modeling to increase probability of success in drug discovery and early development.
Drug Discov Today Technol
; 21-22: 27-34, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27978984
4.
Model-based assessment of erlotinib effect in vitro measured by real-time cell analysis.
J Pharmacokinet Pharmacodyn
; 42(3): 275-85, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25822652
5.
Pharmacokinetic/Pharmacodynamic predictors of clinical potency for hepatitis C virus nonnucleoside polymerase and protease inhibitors.
Antimicrob Agents Chemother
; 56(6): 3144-56, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22470110
6.
Mass spectrometry-based quantification of CYP enzymes to establish in vitro/in vivo scaling factors for intestinal and hepatic metabolism in beagle dog.
Pharm Res
; 29(7): 1832-42, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354837
7.
Model-Informed Artificial Intelligence: Reinforcement Learning for Precision Dosing.
Clin Pharmacol Ther
; 107(4): 853-857, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31955414
8.
Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk.
Cell Rep Med
; 1(5): 100076, 2020 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205069
9.
Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine.
Mol Pharm
; 6(6): 1716-33, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19739673
10.
Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data.
J Pharmacokinet Pharmacodyn
; 36(6): 585-611, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19936896
11.
Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.
Chem Biodivers
; 6(11): 1975-87, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19937834
12.
Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model.
Drug Metab Dispos
; 36(12): 2434-44, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18809732
13.
Importance of target-mediated drug disposition for small molecules.
Drug Discov Today
; 23(12): 2023-2030, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29928850
14.
New strategies to address drug-drug interactions involving OATPs.
Curr Opin Drug Discov Devel
; 10(1): 74-83, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17265745
15.
Metabolic Profiling of Human Long-Term Liver Models and Hepatic Clearance Predictions from In Vitro Data Using Nonlinear Mixed-Effects Modeling.
AAPS J
; 19(2): 534-550, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28050713
16.
Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling.
Clin Pharmacokinet
; 45(12): 1213-26, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-17112297
17.
A novel strategy for physiologically based predictions of human pharmacokinetics.
Clin Pharmacokinet
; 45(5): 511-42, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640456
18.
Cryopreserved human hepatocytes in suspension are a convenient high throughput tool for the prediction of metabolic clearance.
Eur J Pharm Biopharm
; 63(3): 347-55, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16621491
19.
Prediction of hepatic clearance using cryopreserved human hepatocytes: a comparison of serum and serum-free incubations.
J Pharm Pharmacol
; 58(5): 633-41, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640832
20.
Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib.
Mol Cancer Ther
; 15(12): 3110-3119, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27638857