Detalhe da pesquisa
1.
Deletion of PTP4A3 phosphatase in high grade serous ovarian cancer cells decreases tumorigenicity and produces marked changes in intracellular signaling pathways and cytokine release.
J Pharmacol Exp Ther
; 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580450
2.
Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase.
J Pharmacol Exp Ther
; 384(3): 429-438, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36627205
3.
The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells.
Am J Physiol Lung Cell Mol Physiol
; 321(2): L477-L484, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34156871
4.
Synthesis and evaluation of bifunctional PTP4A3 phosphatase inhibitors activating the ER stress pathway.
Bioorg Med Chem Lett
; 46: 128167, 2021 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34089839
5.
Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin.
Mol Pharmacol
; 98(6): 648-657, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32978326
6.
Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production.
Int J Mol Sci
; 21(7)2020 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32260565
7.
Drugging Undruggable Molecular Cancer Targets.
Annu Rev Pharmacol Toxicol
; 56: 23-40, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26527069
8.
Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase.
J Pharmacol Exp Ther
; 371(3): 652-662, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31601683
9.
A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion.
FASEB J
; 32(10): 5661-5673, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29746167
10.
Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors.
Bioorg Med Chem Lett
; 29(16): 2008-2015, 2019 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31307888
11.
In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors.
Org Biomol Chem
; 17(9): 2448-2466, 2019 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30746541
12.
Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors.
Bioorg Med Chem Lett
; 26(15): 3581-5, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27381083
13.
Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor.
Org Biomol Chem
; 14(27): 6398-402, 2016 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27291491
14.
Chemical genetics of Plasmodium falciparum.
Nature
; 465(7296): 311-5, 2010 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20485428
15.
Protein-tyrosine phosphatase 4A3 (PTP4A3) promotes vascular endothelial growth factor signaling and enables endothelial cell motility.
J Biol Chem
; 289(9): 5904-13, 2014 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24403062
16.
Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B.
Bioorg Med Chem
; 23(12): 2810-8, 2015 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25703307
17.
2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.
Bioorg Med Chem Lett
; 24(21): 5081-5, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25288188
18.
Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death.
J Pharmacol Exp Ther
; 347(3): 669-80, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24068833
19.
An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium.
SLAS Discov
; 28(6): 249-254, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36796645
20.
Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations.
FEBS J
; 290(20): 4950-4965, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37428551