Detalhe da pesquisa
1.
Exploring the conformational landscapes of protein kinases: perspectives from FRET and DEER.
Biochem Soc Trans
; 2024 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38778760
2.
Allostery governs Cdk2 activation and differential recognition of CDK inhibitors.
Nat Chem Biol
; 17(4): 456-464, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33526892
3.
Structural basis for the recognition of c-Src by its inactivator Csk.
Cell
; 134(1): 124-34, 2008 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614016
4.
Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.
Proc Natl Acad Sci U S A
; 115(51): E11894-E11903, 2018 12 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30518564
5.
A water-mediated allosteric network governs activation of Aurora kinase A.
Nat Chem Biol
; 13(4): 402-408, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28166210
6.
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.
Biochemistry
; 57(31): 4675-4689, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004690
7.
A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.
Nat Chem Biol
; 10(2): 127-32, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24292070
8.
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
Elife
; 132024 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742856
9.
Allosteric coupling asymmetry mediates paradoxical activation of BRAF by type II inhibitors.
bioRxiv
; 2023 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37131649
10.
Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice.
J Med Chem
; 66(3): 1928-1940, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36701569
11.
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding.
Nat Commun
; 14(1): 3213, 2023 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270540
12.
Experimental quantification of electrostatics in X-H···π hydrogen bonds.
J Am Chem Soc
; 134(46): 18986-97, 2012 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23098379
13.
Direct measurements of electric fields in weak OH···π hydrogen bonds.
J Am Chem Soc
; 133(43): 17414-9, 2011 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21936553
14.
Phosphate vibrations probe local electric fields and hydration in biomolecules.
J Am Chem Soc
; 133(34): 13236-9, 2011 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-21809829
15.
Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2.
ACS Chem Biol
; 15(7): 1759-1764, 2020 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433863
16.
A Src-like inactive conformation in the abl tyrosine kinase domain.
PLoS Biol
; 4(5): e144, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640460
17.
The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.
Sci Signal
; 12(566)2019 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30696704
18.
A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.
Elife
; 72018 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29465396
19.
Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain.
PLoS One
; 7(4): e29828, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22493660
20.
Solvent-induced infrared frequency shifts in aromatic nitriles are quantitatively described by the vibrational Stark effect.
J Phys Chem B
; 116(35): 10470-6, 2012 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-22448878