Detalhe da pesquisa
1.
Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile.
J Nat Prod
; 85(4): 1141-1146, 2022 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35380836
2.
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Antimicrob Agents Chemother
; 63(1)2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373794
3.
Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor.
Bioorg Med Chem Lett
; 28(8): 1397-1403, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29545102
4.
Discovery of novel spiro 1,3,4-thiadiazolines as potent, orally bioavailable and brain penetrant KSP inhibitors.
Bioorg Med Chem
; 23(10): 2424-34, 2015 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25868746
5.
Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.
Antimicrob Agents Chemother
; 58(4): 2387-92, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24514098
6.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
7.
SCH529074, a small molecule activator of mutant p53, which binds p53 DNA binding domain (DBD), restores growth-suppressive function to mutant p53 and interrupts HDM2-mediated ubiquitination of wild type p53.
J Biol Chem
; 285(14): 10198-212, 2010 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20124408
8.
Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 20(22): 6739-43, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855207
9.
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
J Med Chem
; 60(9): 3851-3865, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322556
10.
TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Sci Transl Med
; 8(329): 329ra32, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26962156
11.
Discovery of wall teichoic acid inhibitors as potential anti-MRSA ß-lactam combination agents.
Chem Biol
; 20(2): 272-84, 2013 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23438756
12.
Restoring methicillin-resistant Staphylococcus aureus susceptibility to ß-lactam antibiotics.
Sci Transl Med
; 4(126): 126ra35, 2012 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22440737
13.
SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors.
Cancer Chemother Pharmacol
; 68(4): 923-33, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21298383
14.
A fully human insulin-like growth factor-I receptor antibody SCH 717454 (Robatumumab) has antitumor activity as a single agent and in combination with cytotoxics in pediatric tumor xenografts.
Mol Cancer Ther
; 9(2): 410-8, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20124453
15.
SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics.
Mol Cancer Ther
; 9(11): 2993-3002, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20978164
16.
Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
ACS Med Chem Lett
; 1(5): 214-8, 2010 Aug 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900197