Detalhe da pesquisa
1.
ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P2 exchange.
EMBO J
; 40(14): e106871, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34124795
2.
A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions.
Proc Natl Acad Sci U S A
; 119(14): e2114397119, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35312342
3.
Structural basis of Focal Adhesion Kinase activation on lipid membranes.
EMBO J
; 39(19): e104743, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32779739
4.
New insights into FAK structure and function in focal adhesions.
J Cell Sci
; 135(20)2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36239192
5.
A new layer of phosphoinositide-mediated allosteric regulation uncovered for SHIP2.
FASEB J
; 35(8): e21815, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34314064
6.
The FERM domain: organizing the structure and function of FAK.
Nat Rev Mol Cell Biol
; 11(11): 802-14, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20966971
7.
Structural and mechanistic insights into mechanoactivation of focal adhesion kinase.
Proc Natl Acad Sci U S A
; 116(14): 6766-6774, 2019 04 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30877242
8.
Roles of Membrane Domains in Integrin-Mediated Cell Adhesion.
Int J Mol Sci
; 21(15)2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32752284
9.
Synthesis of novel 1,2,4-triazine scaffold as FAK inhibitors with antitumor activity.
Bioorg Med Chem Lett
; 27(8): 1727-1730, 2017 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28284808
10.
Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes.
Proc Natl Acad Sci U S A
; 111(31): E3177-86, 2014 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25049397
11.
Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.
J Biol Chem
; 290(41): 24975-85, 2015 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26286748
12.
Allosteric regulation of focal adhesion kinase by PIP2 and ATP.
Biophys J
; 108(3): 698-705, 2015 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25650936
13.
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.
Bioorg Med Chem Lett
; 23(16): 4552-6, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845217
14.
TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy.
J Med Chem
; 65(2): 1585-1607, 2022 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978799
15.
A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
Cancer Res
; 81(21): 5438-5450, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417202
16.
FAK Structure and Regulation by Membrane Interactions and Force in Focal Adhesions.
Biomolecules
; 10(2)2020 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31991559
17.
Design, Synthesis, and Biological Evaluation of Covalent Inhibitors of Focal Adhesion Kinase (FAK) against Human Malignant Glioblastoma.
J Med Chem
; 63(21): 12707-12724, 2020 11 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33119295
18.
A Synergistic Anticancer FAK and HDAC Inhibitor Combination Discovered by a Novel Chemical-Genetic High-Content Phenotypic Screen.
Mol Cancer Ther
; 19(2): 637-649, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31784455
19.
Structure-Based Design, Synthesis, and Characterization of the First Irreversible Inhibitor of Focal Adhesion Kinase.
ACS Chem Biol
; 13(8): 2067-2073, 2018 08 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29897729
20.
Exome Sequencing of Plasma DNA Portrays the Mutation Landscape of Colorectal Cancer and Discovers Mutated VEGFR2 Receptors as Modulators of Antiangiogenic Therapies.
Clin Cancer Res
; 24(15): 3550-3559, 2018 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29588308