RESUMO
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
Assuntos
Encéfalo/metabolismo , Escolaridade , Feto/metabolismo , Regulação da Expressão Gênica/genética , Estudo de Associação Genômica Ampla , Polimorfismo de Nucleotídeo Único/genética , Doença de Alzheimer/genética , Transtorno Bipolar/genética , Cognição , Biologia Computacional , Interação Gene-Ambiente , Humanos , Anotação de Sequência Molecular , Esquizofrenia/genética , Reino UnidoRESUMO
What motivates citizens to run for office? Recent work has shown that early life parental socialization is strongly associated with a desire to run for office. However, parents not only shape their children's political environment, they also pass along their genes to those same children. A growing area of research has shown that individual differences in a wide range of political behaviors and attitudes are linked to genetic differences. As a result, genetic factors may confound the observed political similarities among parents and their children. This study analyzes Swedish register data containing information on all nominated and elected candidates in the ten parliamentary, county council, and municipal elections from 1982 to 2014 for a large sample of adoptees and their adoptive and biological parents. By studying the similarity in political ambition within both adoptive and biological families, our research design allows us to disentangle so-called "pre-birth" factors, such as genes and pre-natal environment, and "post-birth" factors like parental socialization. We find that the likelihood of standing as a political candidate is twice as high if one's parent has been a candidate. We also find that the effects of pre-birth and post-birth factors are approximately equal in size. In addition, we test a number of potential pre- and post-birth transmission mechanisms. First, disconfirming our expectations, the pre-birth effects do not seem to be mediated by cognitive ability or leadership skills. Second, consistent with a role modeling mechanism, we find evidence of a strong transmission in candidacy status between rearing mothers and their daughters.