Detalhe da pesquisa
1.
Directed RNase H Cleavage of Nascent Transcripts Causes Transcription Termination.
Mol Cell
; 77(5): 1032-1043.e4, 2020 03 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31924447
2.
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.
J Biol Chem
; 299(12): 105475, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37981208
3.
Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD.
Mol Psychiatry
; 28(6): 2445-2461, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37012334
4.
SMN protein is required throughout life to prevent spinal muscular atrophy disease progression.
Hum Mol Genet
; 31(1): 82-96, 2021 12 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34368854
5.
Corticosteroid sensitization drives opioid addiction.
Mol Psychiatry
; 27(5): 2492-2501, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35296810
6.
Long-Term SMN- and Ncald-ASO Combinatorial Therapy in SMA Mice and NCALD-ASO Treatment in hiPSC-Derived Motor Neurons Show Protective Effects.
Int J Mol Sci
; 24(4)2023 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835624
7.
Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1.
Gene Ther
; 29(12): 698-709, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35075265
8.
NCALD Antisense Oligonucleotide Therapy in Addition to Nusinersen further Ameliorates Spinal Muscular Atrophy in Mice.
Am J Hum Genet
; 105(1): 221-230, 2019 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31230718
9.
Knockdown of GADD34 in neonatal mutant SOD1 mice ameliorates ALS.
Neurobiol Dis
; 136: 104702, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31837419
10.
Association between adipocyte fatty acid-binding protein with left ventricular remodelling and diastolic function in type 2 diabetes: a prospective echocardiography study.
Cardiovasc Diabetol
; 19(1): 197, 2020 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33234149
11.
TSUNAMI: an antisense method to phenocopy splicing-associated diseases in animals.
Genes Dev
; 26(16): 1874-84, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22895255
12.
Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease.
Hum Mol Genet
; 26(4): 686-701, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28040732
13.
Antisense-mediated reduction of EphA4 in the adult CNS does not improve the function of mice with amyotrophic lateral sclerosis.
Neurobiol Dis
; 114: 174-183, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29518482
14.
Pharmacologically induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Hum Mol Genet
; 25(5): 964-75, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26758873
15.
Corrigendum to: Pharmacologically-induced mouse model of adult spinal muscular atrophy to evaluate effectiveness of therapeutics after disease onset.
Hum Mol Genet
; 30(9): 843, 2021 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33201218
16.
Pharmacokinetics, pharmacodynamics, and efficacy of a small-molecule SMN2 splicing modifier in mouse models of spinal muscular atrophy.
Hum Mol Genet
; 25(10): 1885-1899, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26931466
17.
Severe neuromuscular denervation of clinically relevant muscles in a mouse model of spinal muscular atrophy.
Hum Mol Genet
; 21(1): 185-95, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21968514
18.
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport.
Mol Neurodegener
; 19(1): 13, 2024 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38282024
19.
Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation.
Nat Neurosci
; 27(1): 34-47, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996528
20.
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
J Biol Chem
; 287(39): 33014-25, 2012 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22851176