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1.
Curr Pharm Biotechnol ; 25(11): 1377-1393, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-39034731

RESUMO

CAR T-cell therapy is a promising approach for cancer treatment, utilizing a patient's own T-cells (autologous cell) or T-cells from a healthy donor (allogeneic cell) to target and destroy cancer cells. Over the last decade, significant advancements have been made in this field, including the development of novel CAR constructs, improved understanding of biology and mechanisms of action, and expanded clinical applications for treating a wider range of cancers. In this review, we provide an overview of the steps involved in the production of CAR T-cells and their mechanism of action. We also introduce different CAR T-cell therapies available, including their implementation, dosage, administration, treatment cost, efficacy, and resistance. Common side effects of CAR T-cell therapy are also discussed. The CAR T-cell products highlighted in this review are FDA-approved products, which include Kymriah® (tisagenlecleucel), Tecartus® (brexucabtagene autoleucel), Abecma® (Idecabtagene vicleucel), Breyanzi® (lisocabtagene maraleucel), and Yescarta® (axicabtagene ciloleucel). In conclusion, CAR T-cell therapy has made tremendous progress over the past decade and has the potential to revolutionize cancer treatment. This review paper provides insights into the progress, challenges, and future directions of CAR T-cell therapy, offering valuable information for researchers, clinicians, and patients.


Assuntos
Imunoterapia Adotiva , Neoplasias , Receptores de Antígenos Quiméricos , United States Food and Drug Administration , Humanos , Imunoterapia Adotiva/métodos , Neoplasias/terapia , Neoplasias/imunologia , Receptores de Antígenos Quiméricos/imunologia , Estados Unidos , Linfócitos T/imunologia , Animais
2.
Asian Spine J ; 15(4): 512-522, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32951406

RESUMO

STUDY DESIGN: Retrospective cohort study. PURPOSE: This study aims to analyze the relationship between body mass index (BMI) subjective patient-reported outcomes (PRO) after 1- and 2-level anterior cervical discectomy and fusion (ACDF). OVERVIEW OF LITERATURE: The prevalence of cervical spondylosis and ACDF in expected to continue rising among the aging population of Asia. Moreover, the prevalence of obesity is also increasing. However, limited information is available about the mechanism by which BMI affects PRO after ACDF. METHODS: Total 878 patients underwent ACDF between 2000 and 2015. After excluding patients with previous cervical instrumentation, >2 levels fused, missing BMI measurement, or neoplastic/trauma indication for surgery, 535 patients were included. The PRO measures of the Neck Disability Index, Numerical Pain Rating Scale (NPRS) for Neck Pain, NPRS for Limb Pain, American Academy of Orthopaedic Surgeons-Neurogenic Symptom Score, and Japanese Orthopaedic Association myelopathy score were used. Patients were grouped based on their preoperative BMI, as per the World Health Organization guidelines for Asian populations. PRO scores were collected preoperatively, at 6 months postoperatively, and 2 years postoperatively. A generalized linear model was used to analyze the relationship of BMI category with the individual score, accounting for several factors that are likely to affect the outcomes. RESULTS: Total 19 (3.4%) were underweight, 155 (28.0%) were normal weight, 112 (20.3%) were overweight, and 267 (48.3%) were obese. Patients across all BMI categories experienced significant and similar improvements in their postoperative PRO scores. There were no significant differences in the preoperative, 6-month postoperative, and 2-year postoperative PRO scores of the groups. Rate of reoperation was highest in patients with grade II obesity at 8.07%; however, the difference was not statistically significant. CONCLUSIONS: Irrespective of the BMI, all patients exhibited similar satisfactory outcomes following ACDF. The results support surgery in all subgroups of patients with symptomatic nerve compression in the cervical spine.

3.
Plast Reconstr Surg ; 123(2): 613-616, 2009 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-19182620

RESUMO

BACKGROUND: Acute compartment syndrome of the hand is an emergency requiring prompt surgical decompression. This cadaveric study aims to identify the myofascial compartments of the hand by detailed dissection and direct visualization, to provide an accurate anatomical basis for surgical decompression. METHODS: Fourteen fresh-frozen cadaveric hands were dissected. The findings were recorded by still digital photography. RESULTS: There was no well-defined tough fascia overlying the thenar muscles, the hypothenar muscles, or the adductor pollicis. Areolar tissue was present between the individual thenar and hypothenar muscles. A distinct band of fascia was noted over the entire length of the ulnar three dorsal interosseous muscles. A band of fascia was noted over the distal portion of the palmar interossei but not over the proximal aspect. The above findings were found in all 14 specimens. A layer of loose areolar tissue was noted over the dorsal aspect of the first web space in eight specimens, whereas a distinct band of fascia was noted overlying the first dorsal interosseous muscle in the remaining six. CONCLUSIONS: This study has shown that no distinct tough fascia surrounded any of the intrinsic muscles of the hand completely. The thin filmy fascia partially encasing some of the muscles is unlikely to contribute to development of compartment syndrome. It is postulated that the unyielding overlying skin may serve as a constricting layer in addition to the fascia and contribute to raised intracompartmental pressures.


Assuntos
Síndromes Compartimentais/patologia , Fáscia/anatomia & histologia , Mãos/anatomia & histologia , Idoso , Idoso de 80 Anos ou mais , Cadáver , Feminino , Humanos , Masculino , Músculo Esquelético/anatomia & histologia
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