TGFA expression is associated with poor prognosis and promotes the development of cervical cancer.

Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are the second most common cancers in women aged 20-39. While HPV screening can help with early detection of cervical cancer, many patients are already in the medium to late stages when they are identified. As a result, searching for novel biomarkers to predict CESC prognosis and propose molecular treatment targets is critical. TGFA is a polypeptide growth factor with a high affinity for the epidermal growth factor receptor. Several studies have shown that TGFA can improve cancer growth and progression, but data on its impact on the occurrence and advancement of CESC is limited. In this study, we used clinical data analysis and bioinformatics techniques to explore the relationship between TGFA and CESC. The results showed that TGFA was highly expressed in cervical cancer tissues and cells. TGFA knockdown can inhibit the proliferation, migration and invasion of cervical cancer cells. In addition, after TGFA knockout, the expression of IL family and MMP family proteins in CESC cell lines was significantly reduced. In conclusion, TGFA plays an important role in the occurrence and development of cervical cancer. Therefore, TGFA may become a new target for cervical cancer treatment.

Method for suppressing the frequency drift of integrated microwave photonic filters.

The significant frequency drift of integrated microwave photonic filters (IMPFs) is caused by relatively independent frequency fluctuations of the optical carrier and the photonic integrated filter, which imposes a rigid limitation on the practical application. In this paper, a novel method is proposed for suppressing the frequency drift of IMPFs. The scheme is implemented by utilizing an on-chip high-Q microring resonator as a frequency monitoring unit to track the instantaneous frequency drifts caused by the optical carrier drift and the temperature fluctuations of the photonic integrated chip. And the same frequency tuning is simultaneously applied on the photonic integrated filter to suppress the frequency drift of IMPFs based on the differential scheme. As a proof of concept, the proposed IMPF scheme is demonstrated on the Si3N4 platform, and the frequency drift is measured to be tens of MHz in one hour. Compared with conventional IMPF schemes, the frequency drift is significantly suppressed by 86.3% without using complex laser frequency stabilization and temperature control systems.