RESUMO
A simplified 4-strata risk stratification approach based on three variables is widespread in pulmonary arterial hypertension (PAH) at follow-up. This study aimed to assess the impact of replacing the 6-min walk test (6MWT) with the peak 02 uptake evaluated by the cardiopulmonary exercise test (CPET) on risk stratification by this scale. We included 180 prevalent patients with PAH from two reference hospitals in Spain, followed up between 2006 and 2022. Patients were included if all the variables of interest were available within a 3-month period on the Spanish Registry of Pulmonary Arterial Hypertension (REHAP): functional class (FC); NT-proBNP; 6MWT; and CPET. The original 4-strata model (NT-proBNP, 6MWT, FC) identified most patients at low or intermediate-low risk (36.7% and 51.1%, respectively). Notably, the modified scale (NT-proBNP, CPET, FC) improved the identification of patients at intermediate-high risk up to 18.9%, and at high risk up to 1.1% in comparison with the previous 12.2% and 0.0% in the original scale. This new model increased the number of patients correctly classified into higher-risk strata (positive NRI of 0.06), as well as classified more patients without events in lower-risk strata (negative NRI of 0.04). The proposed score showed a slightly superior prognostic capacity compared with the original model (Harrel's C-index 0.717 vs. 0.709). Using O2 uptake instead of distance walked in the 6MWT improves the identification of high-risk patients using the 4-strata scale. This change could have relevant prognostic implications and lead to changes in the specific treatment of PAH.
RESUMO
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Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Eletrocardiografia , Transplante de Coração/efeitos adversos , Flutter Atrial/diagnóstico , Cardioversão ElétricaRESUMO
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Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Cardiomiopatia Hipertrófica/fisiopatologia , EletrocardiografiaRESUMO
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Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Embolia Pulmonar/terapia , Oxigenação por Membrana Extracorpórea/métodos , Estudos Retrospectivos , Parada Cardíaca/complicações , Resultado do Tratamento , Taxa de SobrevidaRESUMO
La hipertensión arterial pulmonar (HAP) es una enfermedad rara caracterizada por un remodelado adverso del árbol arterial que conlleva un aumento de las resistencias vasculares con el subsecuente incremento de la poscarga del ventrículo derecho y el desarrollo, finalmente, de insuficiencia cardiaca. El curso de la enfermedad conlleva un mal pronóstico, al que se asocia el retraso en el diagnóstico e inicio de tratamiento motivado por la clínica inespecífica y el desconocimiento de la entidad. Las recomendaciones más recientes se centran en optimizar el diagnóstico precoz diferencial frente a otras causas de hipertensión pulmonar, con el fin de iniciar un tratamiento adecuado utilizando como referencia la estimación de riesgo de mortalidad del paciente. En los últimos años, con la mejora en el proceso diagnóstico, la aparición de nuevos tratamientos específicos y la creación de unidades de referencia especializadas en esta enfermedad, se ha conseguido mejorar el pronóstico y la calidad de vida de los pacientes con HAP. (AU)
Pulmonary arterial hypertension (PAH) is a rare disease characterized by adverse remodeling of the arterial tree leading to increased vascular resistance with subsequent increase in right ventricular afterload and eventual development of heart failure. The nonspecific clinical manifestations and lack of knowledge of pathology lead to a poor prognosis associated with delay in diagnosis and initiation of treatment. The most recent recommendations focus on optimizing the early differential diagnosis with other causes of pulmonary hypertension to initiate appropriate treatment based on the mortality risk estimation. In the last years, with the improvement in the diagnostic process, the emergence of new specific treatments, and the creation of specialized referral units for this pathology, the prognosis, and quality of life of patients with PAH have improved significantly. (AU)
Assuntos
Humanos , Insuficiência Cardíaca , Ventrículos do Coração , Hipertensão Pulmonar/diagnóstico , Hipertensão Pulmonar/etiologia , Hipertensão Pulmonar/terapia , Hipertensão/diagnóstico , Hipertensão/etiologia , Hipertensão/terapia , Qualidade de VidaRESUMO
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