Detalhe da pesquisa
1.
Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.
J Med Chem
; 48(20): 6169-73, 2005 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-16190743
2.
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.
J Med Chem
; 47(27): 6662-5, 2004 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15615513
3.
CCR5 antagonists: 3-(pyrrolidin-1-yl)propionic acid analogues with potent anti-HIV activity.
Org Lett
; 5(14): 2473-5, 2003 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12841758
4.
Discovery and design of novel HSP90 inhibitors using multiple fragment-based design strategies.
Chem Biol Drug Des
; 70(1): 1-12, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17630989
5.
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 16(13): 3564-8, 2006 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16621543
6.
Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Bioorg Med Chem Lett
; 15(8): 2129-34, 2005 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15808483
7.
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Science
; 296(5566): 346-9, 2002 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11923495
8.
Binding of 2-aryl-4-(piperidin-1-yl)butanamines and 1,3,4-trisubstituted pyrrolidines to human CCR5: a molecular modeling-guided mutagenesis study of the binding pocket.
Biochemistry
; 42(6): 1544-50, 2003 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12578367
9.
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.
Bioorg Med Chem Lett
; 14(19): 4861-6, 2004 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15341940
10.
CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
Bioorg Med Chem Lett
; 12(4): 677-9, 2002 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11844699
11.
Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Bioorg Med Chem Lett
; 14(4): 941-5, 2004 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-15012998
12.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.
Bioorg Med Chem Lett
; 12(20): 3001-4, 2002 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12270193
13.
1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists: modifications of the arylpropylpiperidine side chains.
Bioorg Med Chem Lett
; 13(1): 119-23, 2003 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-12467630