Pesquisa | BVS CLAP/SMR-OPAS/OMS

1.

Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.

Almutairi, Mubarak; Lister, Adam; Zhao, Qing; Line, James; Adair, Kareena; Tailor, Arun; Waddington, James; Clarke, Elsie; Gardner, Joshua; Thomson, Paul; Harper, Nicolas; Sun, Yonghu; Sun, Lele; Ostrov, David A; Liu, Hong; MacEwan, David J; Pirmohamed, Munir; Meng, Xiaoli; Zhang, Furen; Naisbitt, Dean J.

J Immunol ; 210(8): 1031-1042, 2023 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-36881872

2.

TWEAKing for a fight with GVHD.

MacEwan, David J.

Blood ; 126(4): 429-30, 2015 Jul 23.

Artigo em Inglês | MEDLINE | ID: mdl-26206942

3.

Identification of Bruton's tyrosine kinase as a therapeutic target in acute myeloid leukemia.

Rushworth, Stuart A; Murray, Megan Y; Zaitseva, Lyubov; Bowles, Kristian M; MacEwan, David J.

Blood ; 123(8): 1229-38, 2014 Feb 20.

Artigo em Inglês | MEDLINE | ID: mdl-24307721

4.

Understanding life and death decisions in human leukaemias.

MacEwan, David J; Barrera, Lawrence N; Keadsanti, Sujitra; Rushworth, Stuart A; Shah, Niraj M; Yuan, Tianma; Zaitseva, Lyubov.

Biochem Soc Trans ; 42(4): 747-51, 2014 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-25109952

5.

The high Nrf2 expression in human acute myeloid leukemia is driven by NF-κB and underlies its chemo-resistance.

Rushworth, Stuart A; Zaitseva, Lyubov; Murray, Megan Y; Shah, Niraj M; Bowles, Kristian M; MacEwan, David J.

Blood ; 120(26): 5188-98, 2012 Dec 20.

Artigo em Inglês | MEDLINE | ID: mdl-23077289

6.

TNF mediates the sustained activation of Nrf2 in human monocytes.

Rushworth, Stuart A; Shah, Suharsh; MacEwan, David J.

J Immunol ; 187(2): 702-7, 2011 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-21670314

7.

The importance of Ras in drug resistance in cancer.

Healy, Fiona M; Prior, Ian A; MacEwan, David J.

Br J Pharmacol ; 179(12): 2844-2867, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-33634485

8.

Ibrutinib in relapsed chronic lymphocytic leukemia.

Rushworth, Stuart A; MacEwan, David J; Bowles, Kristian M.

N Engl J Med ; 369(13): 1277-8, 2013 09 26.

Artigo em Inglês | MEDLINE | ID: mdl-24066760

9.

Pharmacological impact of FLT3 mutations on receptor activity and responsiveness to tyrosine kinase inhibitors.

Marensi, Vanessa; Keeshan, Karen R; MacEwan, David J.

Biochem Pharmacol ; 183: 114348, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33242449

10.

Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters.

Kilfoil, Peter; Feng, Shuyun Lily; Bassyouni, Asser; Lee, Tiffany; Leishman, Derek; Li, Dingzhou; MacEwan, David J; Sharma, Parveen; Watt, Eric D; Jenkinson, Stephen.

Eur J Pharmacol ; 912: 174584, 2021 Dec 05.

Artigo em Inglês | MEDLINE | ID: mdl-34678241

11.

HLA Class-IIâRestricted CD8⁺ T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients.

Zhao, Qing; Almutairi, Mubarak; Tailor, Arun; Lister, Adam; Harper, Nicolas; Line, James; Meng, Xiaoli; Pratoomwun, Jirawat; Jaruthamsophon, Kanoot; Sukasem, Chonlaphat; Sun, Yonghu; Sun, Lele; Ogese, Monday O; MacEwan, David J; Pirmohamed, Munir; Liu, Jianjun; Ostrov, David A; Liu, Hong; Zhang, Furen; Naisbitt, Dean J.

J Invest Dermatol ; 141(10): 2412-2425.e2, 2021 10.

Artigo em Inglês | MEDLINE | ID: mdl-33798536

12.

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells.

Linley, Adam J; Karydis, Laura I; Mondru, Anil K; D'Avola, Annalisa; Al Shmrany, Humood; Cicconi, Silvia; Griffin, Rebecca; Forconi, Francesco; Pettitt, Andrew R; Kalakonda, Nagesh; Rawstron, Andrew C; Hillmen, Peter; Steele, Andrew J; MacEwan, David J; Packham, Graham; Prior, Ian A; Slupsky, Joseph R.

Clin Cancer Res ; 27(20): 5647-5659, 2021 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-34380642

13.

Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes.

Rushworth, Stuart A; MacEwan, David J; O'Connell, Maria A.

J Immunol ; 181(10): 6730-7, 2008 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-18981090

14.

TNFR1-induced NF-kappaB, but not ERK, p38MAPK or JNK activation, mediates TNF-induced ICAM-1 and VCAM-1 expression on endothelial cells.

Zhou, Zhigang; Connell, Michelle C; MacEwan, David J.

Cell Signal ; 19(6): 1238-48, 2007 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-17292586

15.

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.

Wilson, Leah J; Linley, Adam; Hammond, Dean E; Hood, Fiona E; Coulson, Judy M; MacEwan, David J; Ross, Sarah J; Slupsky, Joseph R; Smith, Paul D; Eyers, Patrick A; Prior, Ian A.

Cancer Res ; 78(1): 15-29, 2018 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-29254998

16.

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers.

Curtis, Michael J; Alexander, Steve; Cirino, Giuseppe; Docherty, James R; George, Christopher H; Giembycz, Mark A; Hoyer, Daniel; Insel, Paul A; Izzo, Angelo A; Ji, Yong; MacEwan, David J; Sobey, Christopher G; Stanford, S Clare; Teixeira, Mauro M; Wonnacott, Sue; Ahluwalia, Amrita.

Br J Pharmacol ; 175(7): 987-993, 2018 04.

Artigo em Inglês | MEDLINE | ID: mdl-29520785

17.

Themed issue: 'New avenues in cancer prevention and treatment'.

Stefanska, Barbara; Tucker, Steven J; MacEwan, David J.

Br J Pharmacol ; 179(12): 2789-2794, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35146753

18.

Pore forming polyalkylpyridinium salts from marine sponges versus synthetic lipofection systems: distinct tools for intracellular delivery of cDNA and siRNA.

McLaggan, Debra; Adjimatera, Noppadon; Sepcic, Kristina; Jaspars, Marcel; MacEwan, David J; Blagbrough, Ian S; Scott, Roderick H.

BMC Biotechnol ; 6: 6, 2006 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-16412248

19.

The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells.

Tucker, Steven J; McClelland, David; Jaspars, Marcel; Sepcic, Kristina; MacEwan, David J; Scott, Roderick H.

Biochim Biophys Acta ; 1614(2): 171-81, 2003 Aug 07.

Artigo em Inglês | MEDLINE | ID: mdl-12896810

20.

TNF receptor subtype signalling: differences and cellular consequences.