RESUMO
BACKGROUND: Androgen deprivation therapy (ADT) for prostate cancer is associated with cardiovascular comorbidities and numerous adverse effects decreasing health-related quality of life. Both exercise and dietary interventions have shown promise in reducing ADT-related negative sequelae. However, feasibility for personalized combined exercise/nutrition/education interventions is not well established. OBJECTIVE: The purpose of this randomized, controlled, mixed-methods pilot study was to evaluate the feasibility of a nurse-led, telephone-delivered education, exercise, and nutrition intervention, Staying Strong & Healthy, to minimize ADT-related cardiovascular/metabolic risks and symptoms. METHODS: Staying Strong & Healthy involves individually tailored education, exercise (aerobic and resistance), and nutrition intervention delivered over 6 months and was compared with attention control. The primary quantitative outcome measure was change from baseline in low-density lipoprotein. Secondary outcomes included change in lipid levels (total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides), fasting blood glucose, hemoglobin A 1c , health-related quality of life, and diet quality. Assessments were performed at baseline, 6 months, and 12 months. RESULTS: Feasibility was demonstrated by low attrition rates and high participant satisfaction. No between-group differences were demonstrated in the cardiovascular/metabolic outcomes. Significant within-group improvements were noted for high-density lipoprotein and hemoglobin A 1c in the intervention group. CONCLUSION: The study results indicate that participation in a personalized, nurse-delivered exercise, nutrition, and educational intervention is feasible and acceptable to men with prostate cancer receiving ADT. IMPLICATIONS FOR PRACTICE: Future randomized controlled research powered to detect significant differences is needed to confirm the impact of the Staying Strong & Healthy intervention on reduction of the cardiovascular/metabolic impact of ADT for men with prostate cancer.
Assuntos
Neoplasias da Próstata , Qualidade de Vida , Masculino , Humanos , Antagonistas de Androgênios/efeitos adversos , Androgênios , Projetos Piloto , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/complicações , Terapia por Exercício/métodos , Lipoproteínas HDL , Lipoproteínas LDLRESUMO
Trata-se de um relato de experiência de visita técnico-científica e intercâmbio cultural na Escola de Enfermagem Universidade da Califórnia de Los Angeles, no período de janeiro a junho de 2008, durante o desenvolvimento do curso de mestrado na Escola deEnfermagem Anna Nery da Universidade Federal do Rio de Janeiro. O propósito é apresentar as atividades desenvolvidas em disciplinas e grupo de pesquisa. A experiência contribuiu para o aprofundamento de aspectos teóricos relacionados à temática do homem portador de câncer e às possibilidades de intervenção de enfermagem. Sugere-se que estratégias institucionais sejamimplementadas pelos programas de pós-graduação, com o apoio dos órgãos de fomento para viabilizar experiências deintercâmbio internacional durante o curso de mestrado, pois favorecem grande avanço pessoal e profissional, além de estreitar laços de cooperação com pesquisadores e instituições do exterior para o desenvolvimento de pesquisas no seguimento da formação profissional.