Detalhe da pesquisa
1.
Use of PBPK Modeling To Evaluate the Performance of Dissolv It, a Biorelevant Dissolution Assay for Orally Inhaled Drug Products.
Mol Pharm
; 16(3): 1245-1254, 2019 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30640475
2.
Multi-cellular human bronchial models exposed to diesel exhaust particles: assessment of inflammation, oxidative stress and macrophage polarization.
Part Fibre Toxicol
; 15(1): 19, 2018 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29716632
3.
MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 IS ACTIVATED IN RESPONSE TO INHIBITED Akt SIGNALING.
J Biol Chem
; 291(51): 26588, 2016 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986870
4.
Dry powder inhaler formulation comparison: Study of the role of particle deposition pattern and dissolution.
Int J Pharm
; 607: 121025, 2021 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34418472
5.
Dry Generation of CeO2 Nanoparticles and Deposition onto a Co-Culture of A549 and THP-1 Cells in Air-Liquid Interface-Dosimetry Considerations and Comparison to Submerged Exposure.
Nanomaterials (Basel)
; 10(4)2020 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32230801
6.
Exposure of normal and chronic bronchitis-like mucosa models to aerosolized carbon nanoparticles: comparison of pro-inflammatory oxidative stress and tissue injury/repair responses.
Nanotoxicology
; 13(10): 1362-1379, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31462114
7.
Effect of particle deposition density of dry powders on the results produced by an in vitro test system simulating dissolution- and absorption rates in the lungs.
Eur J Pharm Biopharm
; 139: 213-223, 2019 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30862480
8.
Development of Combining of Human Bronchial Mucosa Models with XposeALI® for Exposure of Air Pollution Nanoparticles.
PLoS One
; 12(1): e0170428, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28107509
9.
DissolvIt: An In Vitro Method for Simulating the Dissolution and Absorption of Inhaled Dry Powder Drugs in the Lungs.
Assay Drug Dev Technol
; 15(2): 77-88, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322599
10.
Mdm2 as a sensitive and mechanistically informative marker for genotoxicity induced by benzo[a]pyrene and dibenzo[a,l]pyrene.
Toxicol Sci
; 102(2): 232-40, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18096571
11.
MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling.
J Biol Chem
; 282(4): 2288-96, 2007 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17107963