Detalhe da pesquisa
1.
Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families.
J Pharmacol Exp Ther
; 343(3): 617-27, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22935731
2.
Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 22(14): 4528-31, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22727637
3.
Pyrazole diaminopyrimidines as dual inhibitors of KDR and Aurora B kinases.
Bioorg Med Chem Lett
; 22(14): 4750-5, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22695126
4.
Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families.
Bioorg Med Chem Lett
; 22(9): 3208-12, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22465635
5.
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases.
Bioorg Med Chem Lett
; 21(18): 5620-4, 2011 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21778056
6.
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
J Med Chem
; 51(5): 1231-41, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260617
7.
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett
; 18(8): 2691-5, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18362070
8.
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors.
Bioorg Med Chem Lett
; 18(1): 386-90, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18023347
9.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
10.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17425296
11.
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors.
Mol Cancer Ther
; 5(4): 1007-13, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648572
12.
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor.
Mol Cancer Ther
; 5(4): 995-1006, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648571
13.
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
J Med Chem
; 48(19): 6066-83, 2005 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16162008
14.
Phenoxyphenyl sulfone N-formylhydroxylamines (retrohydroxamates) as potent, selective, orally bioavailable matrix metalloproteinase inhibitors.
J Med Chem
; 45(1): 219-32, 2002 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-11754593
15.
Synthesis and evaluation of a new generation of orally efficacious benzimidazole-based poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors as anticancer agents.
J Med Chem
; 52(21): 6803-13, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19888760
16.
Thienopyridine urea inhibitors of KDR kinase.
Bioorg Med Chem Lett
; 17(5): 1246-9, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17188869
17.
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia.
Blood
; 109(8): 3400-8, 2007 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17209055
18.
High-level bacterial expression and purification of human SirT2 protein for NMR studies.
Protein Expr Purif
; 48(1): 56-60, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16442310
19.
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases.
Bioorg Med Chem Lett
; 16(16): 4326-30, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16735117
20.
Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction.
Anal Biochem
; 332(1): 90-9, 2004 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15301953