Detalhe da pesquisa
1.
A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor.
Nat Chem Biol
; 13(7): 771-778, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28530711
2.
Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety.
J Neurosci
; 33(41): 16262-7, 2013 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24107957
3.
Discovery of a novel IKK-ß inhibitor by ligand-based virtual screening techniques.
Bioorg Med Chem Lett
; 21(1): 577-83, 2011 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078555
4.
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation.
Bioorg Med Chem
; 19(23): 7168-80, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22018919
5.
Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma.
Mol Pharmacol
; 77(4): 559-66, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20064974
6.
One concept, three implementations of 3D pharmacophore-based virtual screening: distinct coverage of chemical search space.
J Chem Inf Model
; 50(7): 1241-7, 2010 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20583761
7.
Characterization of new PPARgamma agonists: benzimidazole derivatives-importance of positions 5 and 6, and computational studies on the binding mode.
Bioorg Med Chem
; 18(16): 5885-95, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20656494
8.
Critical comparison of virtual screening methods against the MUV data set.
J Chem Inf Model
; 49(10): 2168-78, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799417
9.
Sequence-specific positions of water molecules at the interface between DNA and minor groove binders.
Chemphyschem
; 9(18): 2766-71, 2008 Dec 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19025733
10.
Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.
Transl Psychiatry
; 8(1): 1, 2018 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29317594
11.
Identification of HIV-1 reverse transcriptase dual inhibitors by a combined shape-, 2D-fingerprint- and pharmacophore-based virtual screening approach.
Eur J Med Chem
; 50: 216-29, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22361685
12.
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.
Eur J Med Chem
; 48: 284-95, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22222137
13.
Development of anti-viral agents using molecular modeling and virtual screening techniques.
Infect Disord Drug Targets
; 11(1): 64-93, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21303343
14.
Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.
FEBS J
; 278(9): 1444-57, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21348941
15.
Identification of chemically diverse, novel inhibitors of 17ß-hydroxysteroid dehydrogenase type 3 and 5 by pharmacophore-based virtual screening.
J Steroid Biochem Mol Biol
; 125(1-2): 148-61, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300150
16.
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1).
J Med Chem
; 54(9): 3163-74, 2011 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21466167
17.
Leoligin, the major lignan from Edelweiss, activates cholesteryl ester transfer protein.
Atherosclerosis
; 219(1): 109-15, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21820657
18.
Predicting Cyclooxygenase Inhibition by Three-Dimensional Pharmacophoric Profiling. Part I: Model Generation, Validation and Applicability in Ethnopharmacology.
Mol Inform
; 29(1-2): 75-86, 2010 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27463850
19.
Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity.
Mol Cell Biol
; 30(16): 4077-91, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20530198
20.
Hydrogen-bonding patterns of minor groove-binder-DNA complexes reveal criteria for discovery of new scaffolds.
J Chem Inf Model
; 49(4): 1063-9, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19275189