Detalhe da pesquisa
1.
Venetoclax pharmacokinetics in participants with end-stage renal disease undergoing haemodialysis.
Br J Clin Pharmacol
; 90(3): 748-758, 2024 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37855131
2.
Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.
Antimicrob Agents Chemother
; 67(4): e0142522, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-36920244
3.
UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.
Antimicrob Agents Chemother
; 62(9)2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29941635
4.
Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".
Antimicrob Agents Chemother
; 62(11)2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30355750
5.
Discovery of pyrido[2,3-d]pyrimidine-based inhibitors of HCV NS5A.
Bioorg Med Chem Lett
; 23(12): 3627-30, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642966
6.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.
Bioorg Med Chem Lett
; 23(17): 4857-61, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23876987
7.
Species-dependent metabolism of a novel selective α7 neuronal acetylcholine receptor agonist ABT-107.
Xenobiotica
; 43(9): 803-16, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23327533
8.
A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity.
PLoS Negl Trop Dis
; 17(7): e0011392, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37428804
9.
Discovery of diphenyl lactam derivatives as N-type calcium channel blockers.
Bioorg Med Chem Lett
; 22(4): 1716-8, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22277280
10.
Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca²âº channel blockers with analgesic activity.
Bioorg Med Chem
; 20(13): 4128-39, 2012 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22626552
11.
Pharmacokinetic modeling and [¹²³]5-IA-85380 single photon emission computed tomography imaging in baboons: optimization of dosing regimen for ABT-089.
J Pharmacol Exp Ther
; 336(3): 716-23, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21172907
12.
Chroman and tetrahydroquinoline ureas as potent TRPV1 antagonists.
Bioorg Med Chem Lett
; 21(5): 1338-41, 2011 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21315587
13.
Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Mol Cancer Ther
; 20(6): 999-1008, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33785651
14.
In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
J Pharmacol Exp Ther
; 334(3): 875-86, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20504913
15.
Discovery of TRPV1 antagonist ABT-116.
Bioorg Med Chem Lett
; 20(11): 3291-4, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457518
16.
Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives.
Bioorg Med Chem Lett
; 20(22): 6812-5, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855211
17.
Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain.
Bioorg Med Chem
; 18(22): 7816-25, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20965738
18.
Tumour-selective antivascular effects of the novel anti-mitotic compound A-318315: An in vivo rat regional haemodynamic study.
Clin Exp Pharmacol Physiol
; 37(5-6): 636-40, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20132238
19.
Assembling Pharma Resources to Tackle Diseases of Underserved Populations.
ACS Med Chem Lett
; 11(6): 1094-1100, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550987
20.
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned.
Int J Parasitol
; 50(5): 413-422, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32224121