Detalhe da pesquisa
1.
A novel BRET-based assay to investigate binding and residence time of unmodified ligands to the human lysosomal ion channel TRPML1 in intact cells.
J Biol Chem
; 299(6): 104807, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37172730
2.
UHMK1 is a novel splicing regulatory kinase.
J Biol Chem
; 299(4): 103041, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36803961
3.
PRMT inhibition induces a viral mimicry response in triple-negative breast cancer.
Nat Chem Biol
; 18(8): 821-830, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35578032
4.
Discovery of pyrazolo[3,4-d]pyrimidines as novel mitogen-activated protein kinase kinase 3 (MKK3) inhibitors.
Bioorg Med Chem
; 98: 117561, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38157838
5.
Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity.
Antimicrob Agents Chemother
; 67(11): e0058923, 2023 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37819090
6.
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery.
Bioorg Med Chem Lett
; 60: 128588, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104640
7.
RNA interference may result in unexpected phenotypes in Caenorhabditis elegans.
Nucleic Acids Res
; 47(8): 3957-3969, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30838421
8.
Crystal structure of DRIK1, a stress-responsive receptor-like pseudokinase, reveals the molecular basis for the absence of ATP binding.
BMC Plant Biol
; 20(1): 158, 2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32293271
9.
Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer.
Bioorg Med Chem Lett
; 30(8): 127040, 2020 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32085971
10.
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.
Mol Cell
; 48(2): 195-206, 2012 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22959275
11.
Cloning, expression and purification of kinase domains of cacao PR-1 receptor-like kinases.
Protein Expr Purif
; 146: 78-84, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29360581
12.
Post-Translational Modifications and RNA-Binding Proteins.
Adv Exp Med Biol
; 907: 297-317, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27256391
13.
The miR-35-41 family of microRNAs regulates RNAi sensitivity in Caenorhabditis elegans.
PLoS Genet
; 8(3): e1002536, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22412382
14.
An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.
Nat Commun
; 15(1): 3070, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38594249
15.
Novel Dihydropteridinone Derivatives As Potent Inhibitors of the Understudied Human Kinases Vaccinia-Related Kinase 1 and Casein Kinase 1δ/ε.
J Med Chem
; 67(11): 8609-8629, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38780468
16.
Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor.
J Med Chem
; 65(4): 3173-3192, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35167750
17.
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold.
J Med Chem
; 64(18): 13259-13278, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34463505
18.
PRMT5 inhibition disrupts splicing and stemness in glioblastoma.
Nat Commun
; 12(1): 979, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33579912
19.
The C-Terminal Domains SnRK2 Box and ABA Box Have a Role in Sugarcane SnRK2s Auto-Activation and Activity.
Front Plant Sci
; 10: 1105, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620147
20.
Binding and structural analyses of potent inhibitors of the human Ca2+/calmodulin dependent protein kinase kinase 2 (CAMKK2) identified from a collection of commercially-available kinase inhibitors.
Sci Rep
; 9(1): 16452, 2019 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31712618