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1.
No Shinkei Geka ; 52(1): 29-37, 2024 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-38246667

RESUMO

In most microvascular decompression surgeries, surgical maneuvers are performed within normal anatomical structures without any neoplasms. Thus, detailed anatomical knowledge is essential to perform safe and efficient procedures. "Rule of 3" by Rhoton AL Jr. is helpful for understanding not only the anatomy of the posterior fossa but also the three neurovascular compression syndromes. The cerebellar arteries and posterior fossa veins have substantial variability, but a basic understanding of their typical patterns is useful to explore individual cases. To use adequate surgical approaches through the cerebellar tentorial or petrosal surface in individual trigeminal neuralgia surgeries, anatomical knowledge of the bridging veins on the tentorial(the bridging veins into the tentorial sinus)and petrosal surfaces(the superior petrosal vein)is crucial. Fissure openings help to minimize cerebellar retraction, similarly to the sylvian fissure dissection in supratentorial surgeries.


Assuntos
Veias Cerebrais , Cirurgia de Descompressão Microvascular , Humanos , Cerebelo/cirurgia , Dura-Máter , Síndrome
2.
Adv Tech Stand Neurosurg ; 46: 95-107, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37318571

RESUMO

Treatments of schwannoma have dramatically improved in the previous few decades, but preservation of the functions of the originating nerve, such as facial sensation in trigeminal schwannomas, still remains challenging. As the preservation of facial sensation in trigeminal schwannomas has not been analyzed in detail, we here review our surgical experience of more than 50 trigeminal schwannoma patients, particularly focusing on their facial sensation. Since the facial sensation in each trigeminal division showed a different perioperative course even in a single patient, we investigated patient-based outcomes (average of the three divisions in each patient) and division-based outcomes separately. In the evaluation of patient-based outcomes, facial sensation remained postoperatively in 96% of all the patients, and improved in 26% and worsened in 42% of patients with preoperative hypesthesia. Posterior fossa tumors tended to most rarely disrupt facial sensation preoperatively, but were the most difficult to preserve facial sensation postoperatively. Facial pain was relieved in all six patients with preoperative neuralgia. In the division-based evaluation, facial sensation remained postoperatively in 83% of all the trigeminal divisions, and improved in 41% and worsened in 24% of the divisions with preoperative hypesthesia. The V3 region was most favorable before and after surgery, with the most frequent improvement and the least frequent functional loss. To clarify current treatment outcomes of the facial sensation and to achieve more effective preservation, standardized assessment methods of perioperative facial sensation may be required. We also introduce detailed MRI investigation methods for schwannoma, including contrast-enhanced heavily T2-weighted (CISS) imaging, arterial spin labeling (ASL), and susceptibility-weighted imaging (SWI), preoperative embolization for rare vascular-rich tumors, and modified techniques of the transpetrosal approach.


Assuntos
Neoplasias dos Nervos Cranianos , Neurilemoma , Humanos , Hipestesia/patologia , Neurilemoma/diagnóstico por imagem , Neoplasias dos Nervos Cranianos/diagnóstico por imagem , Resultado do Tratamento , Sensação , Nervo Trigêmeo/cirurgia
3.
No Shinkei Geka ; 51(3): 490-499, 2023 May.
Artigo em Japonês | MEDLINE | ID: mdl-37211738

RESUMO

Vestibular schwannoma surgery necessitates intraoperative neuromonitoring to secure long-term tumor control by sufficient tumor removal and preservation of neural function. Therein, facial nerve function can be assessed in real-time and quantitatively by intraoperative continuous facial nerve monitoring with repetitive direct stimulation. The ABR and, further, CNAP, are closely monitored for the continuous assessment of the hearing function. In addition, the evoked masseter and extraocular electromyograms, SEP, MEP, and neuromonitoring of the lower cranial nerves are implemented as needed. In this article, we introduce our neuromonitoring techniques during vestibular schwannoma surgery with an illustrative video.


Assuntos
Neuroma Acústico , Humanos , Neuroma Acústico/cirurgia , Audição/fisiologia , Procedimentos Neurocirúrgicos/métodos , Nervo Facial/fisiologia , Nervos Cranianos
4.
Childs Nerv Syst ; 38(8): 1505-1512, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35585306

RESUMO

PURPOSE: Sporadic vestibular schwannoma (VS) is rare in children in contrast to adults, and detailed investigations of case series of these patients using a single fixed protocol are scarce. This study presents our surgical experience of pediatric VSs without clinical evidence of neurofibromatosis type 2 (NF2) at the initial diagnosis. METHODS: Among 1385 consecutive sporadic VS surgeries, 18 pediatric patients (1.3%; 11-18 years old) were retrospectively investigated. RESULTS: The most common initial symptom was hearing disturbance (72.2%), and 6 patients (33.3%) experienced a delayed diagnosis (over 2 years after initial symptom onset). Preoperative image characteristics of these tumors included a solid tumor, hypervascularity, and significant extension into the internal acoustic meatus, when compared with adults. Preoperative embolization was successfully accomplished for 2 recent hypervascular tumors. The tumor resection rate was 95-100% under sufficient intraoperative neuromonitoring, and no additional surgery was required during the follow-up period (average: 57.9 months). No patients experienced permanent facial nerve palsy, and serviceable hearing function was preserved in 6 of 11 patients. Signs of NF2, such as bilateral VSs, were not identified in any patients during the follow-up. CONCLUSION: Safe and sufficient tumor resection was achieved under detailed neuromonitoring in pediatric patients with sporadic VS, although this tends to be difficult owing to hypervascularity, a small cranium, and significant meatal extension. Preoperative embolization may help safe resection of hypervascular tumors. Subsequent development of NF2 has not been observed up to the most recent follow-up, but careful observation is essential for these younger patients.


Assuntos
Neurofibromatose 1 , Neurofibromatose 2 , Neuroma Acústico , Adolescente , Adulto , Criança , Audição , Humanos , Neurofibromatose 1/cirurgia , Neurofibromatose 2/complicações , Neurofibromatose 2/cirurgia , Neuroma Acústico/diagnóstico por imagem , Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos/métodos , Estudos Retrospectivos , Resultado do Tratamento
5.
Neurosurg Rev ; 45(1): 253-261, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34232407

RESUMO

This article reviews the evolution of microneurosurgical anatomy (MNA) with special reference to the development of anatomy, surgical anatomy, and microsurgery. Anatomy can be said to have started in the ancient Greek era with the work of Hippocrates, Galen, and others as part of the pursuit of natural science. In the sixteenth century, Vesalius made a great contribution in reviving Galenian knowledge while adding new knowledge of human anatomy. Also in the sixteenth century, Ambroise Paré can be said to have started modern surgery. As surgery developed, more detailed anatomical knowledge became necessary for treating complicated diseases. Many noted surgeons at the time were also anatomists eager to spread anatomical knowledge in order to enhance surgical practice. Thus, surgery and anatomy developed together, with advances in each benefiting the other. The concept of surgical anatomy evolved in the eighteenth century and became especially popular in the nineteenth century. In the twentieth century, microsurgery was introduced in various surgical fields, starting with Carl O. Nylen in otology. It flourished and became popularized in the second half of the century, especially in the field of neurosurgery, following Jacobson and Suarez's success in microvascular anastomosis in animals and subsequent clinical application as developed by M.G. Yasargil and others. Knowledge of surgical anatomy as seen under the operating microscope became important for surgeons to perform microneurosurgical procedures accurately and safely, which led to the fuller development of MNA as conducted by many neurosurgeons, among whom A.L. Rhoton, Jr. might be mentioned as representative.


Assuntos
Microcirurgia , Neurocirurgia , Anastomose Cirúrgica , História do Século XIX , História do Século XX , Humanos , Microscopia , Procedimentos Neurocirúrgicos
6.
No Shinkei Geka ; 50(3): 625-633, 2022 May.
Artigo em Japonês | MEDLINE | ID: mdl-35670176

RESUMO

The lateral suboccipital retrosigmoid approach is one of the most established approaches for accessing the posterior cranial fossa. In order to expand the surgical field, several extensions, including(1)extended craniotomy(e.g., far lateral, transcondylar, and transsigmoid approaches), (2)additional intradural osseous or bony drilling(e.g., transmeatal and suprajugular approaches), and (3)fissure dissection(e.g., suprafloccular and infrafloccular approaches), have been described. In this report, we introduce our technique for the retrosigmoid approach and review several extensions as illustrated by schwannoma, meningioma, and epidermoid cyst surgeries.


Assuntos
Cisto Epidérmico , Neoplasias Meníngeas , Meningioma , Neurilemoma , Fossa Craniana Posterior/cirurgia , Cisto Epidérmico/cirurgia , Humanos , Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Neurilemoma/cirurgia
7.
No Shinkei Geka ; 50(3): 645-649, 2022 May.
Artigo em Japonês | MEDLINE | ID: mdl-35670178

RESUMO

Adequate control of bleeding and precise dissection techniques are required at every step of skull base surgery. Prompt identification of bleeding points, appropriate selection of hemostasis technique, and accuracy of the procedure are mandatory. Semi-sharp dissection is a multipurpose technique, while the use of sharp and blunt dissection techniques is based on each situation. In this report, we introduce our hemostasis and dissection techniques, including fibrin glue-soaked hemostatic fabric, Gore-Tex patching, and SS forceps dissection.


Assuntos
Adesivo Tecidual de Fibrina , Procedimentos Neurocirúrgicos , Adesivo Tecidual de Fibrina/uso terapêutico , Hemorragia , Humanos , Procedimentos Neurocirúrgicos/efeitos adversos , Procedimentos Neurocirúrgicos/métodos , Base do Crânio/cirurgia
8.
Neurosurg Rev ; 44(2): 699-708, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32281017

RESUMO

Surgical approaches to the fourth ventricle and its surrounding brainstem regions have changed significantly in the previous 30 years, after the establishment of cerebellomedullary fissure (CMF) opening. With the development of CMF opening techniques, CMF opening surgeries have become widely used for the treatment of various pathologies and have contributed to the improvement of surgical results in posterior fossa surgeries. We here review the historical progress of CMF opening surgeries to help the future progression of neurosurgical treatments. The authors studied the available literature to clarify how CMF opening surgeries have developed and progressed, and how much the idea and development of CMF opening techniques have affected the advancement of posterior fossa surgeries. With the establishment of angiography, anatomical studies on CMF in the 1960s were performed mainly to clarify vascular anatomy on radiological images. After reporting the microsurgical anatomy of CMF in a cadaveric study in 1982, one of the authors (T.M.) first proposed the clinical usefulness of CMF opening in 1992. This new method enabled wide exposure of the fourth ventricle without causing vermian splitting syndrome, and it took the place of the standard approach instead of the conventional transvermian approach. Several authors reported their experiences using this method from the end of the twentieth century to the early twenty-first century, and the naming of the approach, "telovelar approach" by Mussi and Rhoton in 2000 contributed to the global spread of CMF opening surgeries. The approach has become widely applied not only for tumors but also for vascular and brainstem lesions, and has assisted in the development of their surgical treatments, and brought up the idea of various fissure dissection in the posterior fossa. Studies of microsurgical anatomy of the fourth ventricle, including the CMF, has led to new surgical approaches represented by the transCMF/telovelar approach. The CMF opening method caused a revolution in posterior fossa surgeries. The idea was developed based on the experience gained while dissecting the CMF (the roof of the fourth ventricle) in the laboratory. Anatomical studies using cadaveric specimens, particularly their dissection by surgeons themselves, together with a deep understanding of brain anatomy are essential for further advancements in neurosurgical treatments.


Assuntos
Tronco Encefálico/anatomia & histologia , Tronco Encefálico/cirurgia , Quarto Ventrículo/anatomia & histologia , Quarto Ventrículo/cirurgia , Procedimentos Neurocirúrgicos/métodos , Tronco Encefálico/diagnóstico por imagem , Cerebelo/diagnóstico por imagem , Cerebelo/cirurgia , Quarto Ventrículo/diagnóstico por imagem , Humanos , Neoplasias Infratentoriais/diagnóstico por imagem , Neoplasias Infratentoriais/cirurgia , Bulbo/diagnóstico por imagem , Bulbo/cirurgia , Procedimentos Neurocirúrgicos/tendências , Radiografia/tendências
9.
Acta Neurochir (Wien) ; 163(9): 2465-2474, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33942190

RESUMO

BACKGROUND: Although many reports state that only the lateral suboccipital retrosigmoid approach (LSO) should be used for removal of cerebellopontine angle (CPA) epidermoid cysts, it is preferable to use various surgical approaches as appropriate for each patient, for radical resection with an optimal operative field under direct visualization, and for the preservation of cranial nerve (CN) functions. In the present study, we hence focused on the importance of surgical approach selection for removal of CPA epidermoid cysts and analyzed the results of CPA epidermoid cysts after surgery in our series. METHODS: Fifty-four patients who underwent surgery for CPA epidermoid cysts were retrospectively analyzed, regarding their surgical approaches, removal rates, preservation rates of CN function 1 year after surgery, and recurrence. Surgical approaches were selected for patients according to the size and extension of the tumor. RESULTS: Surgical approaches consisted of LSO (20 cases), anterior transpetrosal approach (ATP; 3 cases), combined transpetrosal approach (27 cases), and ATP + LSO (4 cases). Mean tumor content removal and capsule removal rates were 97.4% and 78.3%, respectively. Preservation rates of facial nerve function and useful hearing were 94.4% and 90.7%, respectively. The mean postoperative follow-up time was 62.8 months, and there were two cases of recurrence requiring reoperation about 10 years after surgery. CONCLUSIONS: For CPA epidermoid cyst surgeries, selection of the appropriate surgical approach for each patient and radical resection with an optimal operative field under direct visualization enable tumor removal without the need for reoperation for a long time, with preservation of CN functions.


Assuntos
Cisto Epidérmico , Ângulo Cerebelopontino/cirurgia , Nervos Cranianos , Cisto Epidérmico/cirurgia , Humanos , Estudos Retrospectivos , Resultado do Tratamento
10.
Neuroradiology ; 62(4): 463-471, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31919543

RESUMO

PURPOSE: Hypervascular vestibular schwannomas (HVSs) are a type of the vestibular schwannomas (VSs) that are extremely difficult to remove. We examined whether HVSs can be predicted by using arterial spin labeling (ASL) imaging. METHODS: A total of 103 patients with VSs underwent ASL imaging and digital subtraction angiography (DSA) before surgery. Regional cerebral blood flow (CBF) of gray matter and regional tumor blood flow (TBF) were calculated from ASL imaging, and we defined the ratio of TBF to CBF as the relative TBF (rTBF = TBF/CBF). Angiographic vascularity was evaluated by DSA, and clinical vascularity was evaluated by the degree of intraoperative tumor bleeding. Based on the angiographic and clinical vascularity, the VSs were divided into two categories: HVS and non-HVS. We compared rTBF with angiographic and clinical vascularities, retrospectively. RESULTS: The mean rTBFs of angiographic non-HVSs and HVSs were 1.29 and 2.58, respectively (p < 0.0001). At a cutoff value of 1.55, the sensitivity and specificity were 93.9% and 72.9%, respectively. The mean rTBFs of clinical non-HVS and HVSs were 1.45 and 2.22, respectively (p = 0.0002). At a cutoff value of 1.55, the sensitivity and specificity were 79.4% and 66.7%, respectively. CONCLUSION: The rTBF calculated from ASL imaging correlates well with tumor vascularity and may be useful for predicting HVSs before surgery.


Assuntos
Angiografia Digital , Imageamento por Ressonância Magnética/métodos , Neovascularização Patológica/diagnóstico por imagem , Neuroma Acústico/diagnóstico por imagem , Marcadores de Spin , Adulto , Circulação Cerebrovascular , Feminino , Humanos , Masculino , Neuroma Acústico/cirurgia , Estudos Retrospectivos , Sensibilidade e Especificidade
11.
Acta Neurochir (Wien) ; 162(11): 2619-2628, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32803370

RESUMO

BACKGROUND: In patients with a vestibular schwannoma, some studies have reported that useful hearing preserved initially after surgery deteriorates gradually in the long term. Studies with more patients are needed to clarify the maintenance rate of postoperative hearing function and to identify prognostic of hearing function. METHOD: Ninety-one patients (mean age, 39.5 years; mean tumor size, 18.9 mm) with preserved useful hearing immediately after surgery were retrospectively analyzed. The useful hearing was defined as the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) classes A and B. Hearing tests, including auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE), were evaluated preoperatively, immediately after surgery, and at outpatient follow-up. RESULTS: At the final follow-up (mean, 63.0 months), the useful hearing was maintained in 79 patients (87%), and the hearing class remained unchanged during the follow-up period in 40 patients (44%). Significant predictors of useful hearing maintenance were AAO-HNS class A immediately after surgery, improvement of ABR, and the absence of postoperative DPOAE deterioration. Postoperative DPOAE deterioration correlated with hearing class deterioration. CONCLUSIONS: Despite hearing being preserved in vestibular schwannoma patients immediately after surgery, Thirteen percent lost their useful hearing during the long follow-up period, and hearing class worsened in 55% of the patients. This study, which analyzed one of the largest series of vestibular schwannoma patients, demonstrated that retrocochlear condition is a key factor for useful hearing maintenance. In patients with vestibular schwannoma who have preserved hearing function, regular postoperative monitoring of hearing function is as important as regular MRI.


Assuntos
Perda Auditiva/etiologia , Audição/fisiologia , Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos/efeitos adversos , Adolescente , Adulto , Idoso , Criança , Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia , Feminino , Perda Auditiva/fisiopatologia , Testes Auditivos , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/fisiopatologia , Período Pós-Operatório , Prognóstico , Estudos Retrospectivos , Adulto Jovem
12.
Neurosurg Rev ; 42(1): 73-83, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-28879421

RESUMO

The work performed in Dr. Rhoton's Lab, represented by over 500 publications on microneurosurgical anatomy, greatly contributed to improving the level of neurosurgical treatment throughout the world. The authors reviewed the development and activities of the Lab over 40 years. Dr. Albert L. Rhoton Jr., the founder of, and leader in, this field, displayed great creativity and ingenuity during his life. He devoted himself to perfecting his study methodology, employing high-definition photos and slides to enhance the quality of his published papers. He dedicated his life to the education of neurosurgeons. His "lab team," which included microneuroanatomy research fellows, medical illustrators, lab directors, and secretaries, worked together under his leadership to develop the methods and techniques of anatomical study to complete over 160 microneurosurgical anatomy projects. The medical illustrators adapted computer technologies and integrated art and science in the field of microneurosurgical anatomy. Dr. Rhoton's fellows established methods of injecting colors and pursued a series of projects to innovate surgical approaches and instruments over a 40-year period. They also continued to help Dr. Rhoton to conduct international educational activities after returning to their home countries. Rhoton's Lab became a world-renowned anatomical lab as well as a microsurgical training center and generated the knowledge necessary to perform accurate, gentle, and safe surgery for the sake of patients.


Assuntos
Laboratórios/história , Procedimentos Neurocirúrgicos/história , História do Século XX , Humanos
13.
Acta Neurochir (Wien) ; 161(4): 739-743, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30830271

RESUMO

BACKGROUND: Jugular foramen tumors, particularly those that are triple dumbbell-shaped with intracranial, intraforaminal, and extracranial extensions, are difficult to access surgically. However, advances in neuroimaging, neuromonitoring, and skull base surgery have enabled their safe resection with lower rates of morbidity and mortality. METHOD: We share our experience with the surgical technique for the management of triple dumbbell-shaped jugular foramen schwannomas. CONCLUSION: The infralabyrinthine transjugular transsigmoid approach with high cervical exposure under continuous vagus nerve monitoring enables gross total resection of triple dumbbell-shaped jugular foramen schwannomas, aiming at surgical cure of these benign tumors for appropriately selected patients.


Assuntos
Forâmen Jugular/cirurgia , Neurilemoma/cirurgia , Procedimentos Neurocirúrgicos/métodos , Neoplasias da Base do Crânio/cirurgia , Humanos , Estudos Retrospectivos
14.
Acta Neurochir (Wien) ; 161(11): 2265-2269, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31392568

RESUMO

BACKGROUND: Advances in various diagnostic and/or treatment modalities, including radiological imaging, neuromonitoring, and microsurgical techniques, have resulted in treatments of vestibular schwannomas being aimed at preserving facial and hearing functions while achieving optimal tumor control. METHOD: We describe our surgical technique for hearing preservation in vestibular schwannoma surgery. CONCLUSION: The retrosigmoid transmeatal approach under continuous neuromonitoring (auditory brainstem response, cochlear nerve action potentials, and continuous facial nerve monitoring) enables gross-total resection of vestibular schwannomas, while preserving hearing and facial functions. Radiological assessment and microsurgical techniques, such as meticulous tumor dissection, are also essential for functional preservation with sufficient tumor removal.


Assuntos
Perda Auditiva/prevenção & controle , Monitorização Neurofisiológica Intraoperatória/métodos , Neuroma Acústico/cirurgia , Procedimentos Neurocirúrgicos/métodos , Complicações Pós-Operatórias/prevenção & controle , Potenciais Evocados Auditivos do Tronco Encefálico , Nervo Facial/diagnóstico por imagem , Nervo Facial/cirurgia , Feminino , Audição , Perda Auditiva/etiologia , Humanos , Masculino , Neuroma Acústico/diagnóstico por imagem , Procedimentos Neurocirúrgicos/efeitos adversos , Complicações Pós-Operatórias/etiologia
15.
Neurosurg Focus ; 43(VideoSuppl2): V3, 2017 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28967306

RESUMO

Surgical management of cerebellopontine angle meningiomas is challenging due to the intricate neurovascular structures within the limited operative field and the compression of eloquent structures including the brainstem. Surgery on tumors extending into the temporal bone is especially difficult and demands complicated approaches. However, modifications to the retrosigmoid approach utilizing intradural temporal bone drilling enable access to such tumoral extensions without any additional invasive approaches. This video demonstrates the case of a cerebellopontine angle meningioma extending into the internal acoustic meatus and jugular foramen that was surgically treated through the retrosigmoid transmeatal and suprajugular approaches under continuous vagus nerve monitoring. The video can be found here: https://youtu.be/aUD1vr6TbOc .


Assuntos
Neoplasias Cerebelares/cirurgia , Ângulo Cerebelopontino/cirurgia , Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Procedimentos Neurocirúrgicos/métodos , Osso Temporal/cirurgia , Adulto , Neoplasias Cerebelares/diagnóstico por imagem , Ângulo Cerebelopontino/diagnóstico por imagem , Embolização Terapêutica , Feminino , Humanos , Imageamento por Ressonância Magnética , Neoplasias Meníngeas/diagnóstico por imagem , Meningioma/diagnóstico por imagem , Osso Petroso/cirurgia
16.
Pol J Radiol ; 82: 638-644, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29657629

RESUMO

BACKGROUND: To retrospectively examine the usefulness of gray-scale reversal imaging of T2-weighted images (3D-T2R) in conjunction with other modes of 3D MRI for preoperative assessments in patients with glossopharyngeal neuralgia (GPN) due to neurovascular compression. MATERIAL/METHODS: Imaging findings on 3D-T2R, constructive interference in steady state (CISS), and MRA were analyzed with reference to operative charts in 10 patients with GPN. RESULTS: Offending vessels were associated with the posterior inferior cerebellar artery (PICA) in 9 of 10 patients (90%). Eight of the 10 patients (80%) had offending vessels located at the supraolivary fossette. Of those eight patients, six (75%) had a shift of the ipsilateral vertebral artery to the affected side. Five (42%) and seven (48%) contact points were associated with the root entry/exit zone and the peripheral nerve system segment, respectively. In six of nine contact points (67%), 3D-T2R demonstrated the pathomorphological features at the contact points better than CISS. CONCLUSIONS: The offending vessels were mostly associated with posterior inferior cerebellar arteries, were frequently located at the supraolivary fossette, and had attachments at the root entry/exit zone and at the peripheral segment of the glossopharyngeal nerve, which was well demonstrated on 3D-T2R.

18.
Pestic Biochem Physiol ; 119: 1-8, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25868810

RESUMO

Biotypes of Echinochloa crus-galli var. formosensis with resistance to cyhalofop-butyl, an acetyl-CoA carboxylase (ACCase) inhibitor, have been found in dry-seeded rice fields in Okayama, Japan. We collected two lines with suspected resistance (Ecf27 and Ecf108) from dry-seeded rice fields and investigated their sensitivity to cyhalofop-butyl and other herbicides. Both lines exhibited approximately 7-fold higher resistance to cyhalofop-butyl than a susceptible line. Ecf108 was susceptible to penoxsulam, an acetolactate synthase (ALS) inhibitor. On the other hand, Ecf27 showed resistance to penoxsulam and two other ALS inhibitors: propyrisulfuron and pyriminobac-methyl. The alternative herbicides butachlor, thiobencarb, and bispyribac-sodium effectively controlled both lines. To examine the molecular mechanisms of resistance, we amplified and sequenced the target-site encoding genes in Ecf27, Ecf108, and susceptible lines. Partial sequences of six ACCase genes and full-length sequences of three ALS genes were examined. One of the ACCase gene sequences encodes a truncated aberrant protein due to a frameshift mutation in both lines. Comparisons of the genes among Ecf27, Ecf108, and the susceptible lines revealed that none of the ACCases and ALSs in Ecf27 and Ecf108 have amino acid substitutions that are known to confer herbicide resistance, although a single amino acid substitution was found in each of three ACCases in Ecf108. Our study reveals the existence of a multiple-herbicide resistant biotype of E. crus-galli var. formosensis at Okayama, Japan that shows resistance to cyhalofop-butyl and several ALS inhibitors. We also found a biotype that is resistant only to cyhalofop-butyl among the tested herbicides. The resistance mechanisms are likely to be non-target-site based, at least in the multiple-herbicide resistant biotype.


Assuntos
Butanos/farmacologia , Echinochloa/efeitos dos fármacos , Resistência a Herbicidas , Herbicidas/farmacologia , Nitrilas/farmacologia , Oryza/crescimento & desenvolvimento , Plantas Daninhas/efeitos dos fármacos , Sementes/crescimento & desenvolvimento , Acetolactato Sintase/genética , Acetolactato Sintase/metabolismo , Acetil-CoA Carboxilase/genética , Acetil-CoA Carboxilase/metabolismo , Echinochloa/enzimologia , Echinochloa/genética , Oryza/enzimologia , Oryza/genética , Proteínas de Plantas/genética , Proteínas de Plantas/metabolismo , Plantas Daninhas/enzimologia , Plantas Daninhas/genética , Sementes/enzimologia , Sementes/genética
19.
Neuropathology ; 34(4): 406-13, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24612193

RESUMO

We studied one frontal lobe tumor and multiple spinal cord tumors (one in an extramedullary location) that had been resected from a 24-year-old man. The frontal lobe tumor was well demarcated and non-infiltrating, and consisted of eosinophilic, elongated fibrillary cells arranged in a fascicular pattern. A similar histology was reproduced in the spinal cord tumors, with additional areas showing standard features of ependymoma. Immunohistochemical and ultrastructural observations revealed that all the tumors were ependymal in nature with positivity for GFAP and epithelial membrane antigen and negativity for oligodendrocyte transcription factor 2, showing intra- and intercellular microrosettes, leading us to a diagnosis of tanycytic ependymoma for the frontal lobe tumor and tanycytic ependymoma with ordinary ependymomatous component for the spinal cord tumors. The spinal extramedullary tumor was a schwannoma. Importantly, a heterozygous truncating mutation in the NF2 gene was identified in the blood lymphocytes from the patient. It is known that multiple nervous system tumors can occur in neurofibromatosis type 2 (NF2), which is caused by mutation in the NF2 gene, and that occurrence of ependymoma, including the tanycytic variant, can be associated with this genetic condition. The present case provides further information about the clinicopathology of tanycytic ependymoma with details of the immunohistochemical, ultrastructural and genetic features.


Assuntos
Neoplasias Encefálicas/ultraestrutura , Ependimoma/ultraestrutura , Lobo Frontal/ultraestrutura , Neoplasias da Medula Espinal/ultraestrutura , Ependimoma/genética , Humanos , Masculino , Mutação , Neurofibromina 2/genética , Adulto Jovem
20.
Neurosurg Rev ; 37(4): 535-456, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24781190

RESUMO

During surgeries in the upper cerebellopontine angle (CPA), the superior petrosal veins (SPVs) often act as obstacles; and their sectioning sometimes causes serious complications. In this study, we introduced a classification system for the SPVs wherein their tributaries were classified into four groups on the basis of their courses and draining areas. We furthermore explained the detailed anatomy of the vein of the cerebellopontine fissure, which is the largest tributary. In surgeries of petrous apex meningioma, the knowledge of the displacement pattern of the vein is very helpful for avoiding major venous complications. Therefore, we elucidated its anatomical situation in relation to the original portion of the meningioma and the natural draining point of the vein into the superior petrosal sinus (SPS) in each patient. In addition, we described the methods and techniques used to expose and manage the vein of the cerebellopontine fissure during surgery using the lateral suboccipital retrosigmoid approach. Presenting two illustrative cases, we recommend that the initial exposure of the tumor should be performed through the infratentorial lateral supracerebellar route and that the suprafloccular cistern is the best area to find the vein of the cerebellopontine fissure. We emphasized the importance of the preservation of the vein of the cerebellopontine fissure and also proposed the order for exposure of SPV tributaries during upper CPA surgery using the retrosigmoid approach.


Assuntos
Neoplasias Cerebelares/cirurgia , Veias Cerebrais/anatomia & histologia , Veias Cerebrais/cirurgia , Cavidades Cranianas/cirurgia , Meningioma/cirurgia , Osso Petroso/anatomia & histologia , Osso Petroso/cirurgia , Adulto , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/cirurgia , Neoplasias Cerebelares/patologia , Ângulo Cerebelopontino/cirurgia , Cavidades Cranianas/anatomia & histologia , Feminino , Humanos , Masculino , Meningioma/patologia , Pessoa de Meia-Idade , Neoplasias da Base do Crânio/patologia , Neoplasias da Base do Crânio/cirurgia
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