Detalhe da pesquisa
1.
Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia.
Blood
; 138(23): 2313-2326, 2021 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34110416
2.
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Angew Chem Int Ed Engl
; 60(51): 26663-26670, 2021 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34614283
3.
Organocatalytic, diastereo- and enantioselective synthesis of nonsymmetric cis-stilbene diamines: a platform for the preparation of single-enantiomer cis-imidazolines for protein-protein inhibition.
J Org Chem
; 79(15): 6913-38, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25017623
4.
Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines.
Nat Commun
; 15(1): 482, 2024 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38228616
5.
Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design.
ACS Med Chem Lett
; 14(2): 141-145, 2023 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36793425
6.
From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors.
Eur J Med Chem
; 251: 115246, 2023 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36898329
7.
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
ACS Med Chem Lett
; 13(3): 475-482, 2022 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35300081
8.
Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators.
J Med Chem
; 64(11): 7296-7311, 2021 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34042448
9.
Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
Nat Commun
; 11(1): 4931, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33004795
10.
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains.
Bioorg Med Chem Lett
; 18(3): 942-5, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18180157
11.
Solution structure of recombinant somatomedin B domain from vitronectin produced in Pichia pastoris.
Protein Sci
; 16(9): 1934-45, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17766387
12.
Performance of a docking/molecular dynamics protocol for virtual screening of nutlin-class inhibitors of Mdmx.
J Mol Graph Model
; 74: 54-60, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28351017
13.
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J Mol Biol
; 428(6): 1290-1303, 2016 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26812210
14.
Efficacy of Retinoids in IKZF1-Mutated BCR-ABL1 Acute Lymphoblastic Leukemia.
Cancer Cell
; 28(3): 343-56, 2015 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26321221
15.
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells.
Nat Genet
; 47(6): 607-14, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25938942
16.
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.
J Mol Biol
; 415(5): 881-99, 2012 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-22178474
17.
A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription.
Biopolymers
; 95(1): 24-30, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20872873
18.
PqsD is responsible for the synthesis of 2,4-dihydroxyquinoline, an extracellular metabolite produced by Pseudomonas aeruginosa.
J Biol Chem
; 283(43): 28788-94, 2008 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-18728009
19.
A model for the three-dimensional structure of human plasma vitronectin from small-angle scattering measurements.
Biochemistry
; 44(2): 565-74, 2005 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15641781
20.
The solution structure of the N-terminal domain of human vitronectin: proximal sites that regulate fibrinolysis and cell migration.
J Biol Chem
; 279(28): 29359-66, 2004 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15123712