Detalhe da pesquisa
1.
Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature
; 556(7699): 122-125, 2018 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29512653
2.
Selective small-molecule inhibition of an RNA structural element.
Nature
; 526(7575): 672-7, 2015 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-26416753
3.
Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.
PLoS Pathog
; 12(5): e1005585, 2016 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27144276
4.
Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Bioorg Med Chem Lett
; 26(19): 4743-4747, 2016 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27575474
5.
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.
J Biol Chem
; 289(26): 18008-21, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821719
6.
Modulating the interaction between CDK2 and cyclin A with a quinoline-based inhibitor.
Bioorg Med Chem Lett
; 24(1): 199-203, 2014 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24332088
7.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem
; 67(5): 3935-3958, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38365209
8.
Structure Guided Discovery of Novel Pan Metallo-ß-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J Med Chem
; 67(5): 3400-3418, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387069
9.
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases.
Commun Biol
; 6(1): 649, 2023 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37337079
10.
Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.
Sci Rep
; 13(1): 13668, 2023 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37608223
11.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
12.
Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901.
Biochemistry
; 50(37): 7964-76, 2011 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21793567
13.
Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.
Eur J Med Chem
; 224: 113686, 2021 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34303079
14.
Crystal structures of MEK1 binary and ternary complexes with nucleotides and inhibitors.
Biochemistry
; 48(12): 2661-74, 2009 Mar 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-19161339
15.
Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.
J Mol Biol
; 429(7): 1030-1044, 2017 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28232034
16.
Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.
Cell Chem Biol
; 24(5): 576-588.e6, 2017 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28434876
17.
Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
J Med Chem
; 60(9): 3851-3865, 2017 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28322556
18.
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.
J Biomol Screen
; 21(6): 579-89, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27028606
19.
TarO-specific inhibitors of wall teichoic acid biosynthesis restore ß-lactam efficacy against methicillin-resistant staphylococci.
Sci Transl Med
; 8(329): 329ra32, 2016 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26962156
20.
Development of a fluorescence polarization bead-based coupled assay to target different activity/conformation states of a protein kinase.
J Biomol Screen
; 9(4): 309-21, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15191648