Detalhe da pesquisa
1.
Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α.
J Biol Chem
; 298(9): 102284, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35868561
2.
Insulin purification-Innovation continuum via synthesis of fundamentals, technology, and modeling.
Biotechnol Bioeng
; 2023 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37200159
3.
NMR Data-Driven Docking of HDM2-Inhibitor Complexes.
Chembiochem
; 23(6): e202100570, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35104390
4.
Identification of preferred multimodal ligand-binding regions on IgG1 FC using nuclear magnetic resonance and molecular dynamics simulations.
Biotechnol Bioeng
; 118(2): 809-822, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33107976
5.
Probing IgG1 FC-Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach.
Langmuir
; 37(41): 12188-12203, 2021 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34633195
6.
NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions.
Chembiochem
; 21(3): 315-319, 2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31283075
7.
Diffusion Profiling of Therapeutic Proteins by Using Solution NMR Spectroscopy.
Chembiochem
; 20(7): 896-899, 2019 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30515922
8.
Investigating protein-excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy.
MAbs
; 14(1): 2124902, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36166705
9.
Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.
J Med Chem
; 65(7): 5593-5605, 2022 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35298158
10.
Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments.
MAbs
; 13(1): 1978132, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34612804
11.
Profiling Insulin Oligomeric States by 1H NMR Spectroscopy for Formulation Development of Ultra-Rapid-Acting Insulin.
J Pharm Sci
; 109(1): 922-926, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31449814
12.
Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Nonhuman Primates of the Anti-PD-1 Antibody Pembrolizumab.
Mol Cancer Ther
; 19(6): 1298-1307, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32229606
13.
Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.
ACS Chem Biol
; 13(3): 820-831, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29412640
14.
NMR Binding and Functional Assays for Detecting Inhibitors of S. aureus MnaA.
J Biomol Screen
; 21(6): 579-89, 2016 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-27028606
15.
NMR-based approaches for lead discovery.
Curr Opin Drug Discov Devel
; 5(4): 630-47, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12197321
16.
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
J Med Chem
; 47(10): 2486-98, 2004 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15115392
17.
A model analysis of costs of blood pressure destabilization and edema associated with rofecoxib and celecoxib among older patients with osteoarthritis and hypertension in a Medicare Choice population.
Clin Ther
; 25(2): 647-62, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12749519
18.
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors.
ACS Med Chem Lett
; 2(8): 632-7, 2011 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900358
19.
Screening of protein kinases by ATP-STD NMR spectroscopy.
J Am Chem Soc
; 127(22): 7978-9, 2005 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15926798
20.
Structures of protein-protein complexes are docked using only NMR restraints from residual dipolar coupling and chemical shift perturbations.
J Am Chem Soc
; 124(10): 2104-5, 2002 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-11878950