1.
J Infect Dis
; 230(3): e737-e742, 2024 Sep 23.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38441336
RESUMO
We previously described a novel Plasmodium vivax invasion mechanism into human reticulocytes via the PvRBP2a-CD98 receptor-ligand pair. Using linear epitope mapping, we assessed the PvRBP2a epitopes involved in CD98 binding and recognized by antibodies from patients who were infected. We identified 2 epitope clusters mediating PvRBP2a-CD98 interaction. Cluster B (PvRBP2a431-448, TAALKEKGKLLANLYNKL) was the target of antibody responses in humans infected by P vivax. Peptides from each cluster were able to prevent live parasite invasion of human reticulocytes. These results provide new insights for development of a malaria blood-stage vaccine against P vivax.
Assuntos
Anticorpos Antiprotozoários , Mapeamento de Epitopos , Malária Vivax , Plasmodium vivax , Proteínas de Protozoários , Reticulócitos , Humanos , Plasmodium vivax/imunologia , Proteínas de Protozoários/imunologia , Proteínas de Protozoários/metabolismo , Proteínas de Protozoários/genética , Malária Vivax/imunologia , Malária Vivax/parasitologia , Reticulócitos/parasitologia , Reticulócitos/metabolismo , Reticulócitos/imunologia , Anticorpos Antiprotozoários/imunologia , Antígenos de Protozoários/imunologia , Antígenos de Protozoários/metabolismo , Epitopos/imunologia , Vacinas Antimaláricas/imunologia , Proteínas de Membrana
2.
PLoS Med
; 5(6): e133, 2008 Jun 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18563964