Detalhe da pesquisa
1.
Characterizing Pharmacokinetic-Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation.
J Pharmacol Exp Ther
; 369(2): 223-233, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30804001
2.
Pharmacological evaluation of selective α2c-adrenergic agonists in experimental animal models of nasal congestion.
J Pharmacol Exp Ther
; 349(1): 75-84, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24492651
3.
Etanercept ameliorates inflammation and pain in a novel mono-arthritic multi-flare model of streptococcal cell wall induced arthritis.
BMC Musculoskelet Disord
; 15: 409, 2014 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-25477192
4.
Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).
J Pharmacol Exp Ther
; 337(1): 256-66, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21233198
5.
Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757.
Pharmacology
; 88(1-2): 50-4, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21757975
6.
Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.
J Med Chem
; 64(8): 5137-5156, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33797901
7.
The efficacy of a NOP1 agonist (SCH486757) in subacute cough.
Lung
; 188 Suppl 1: S47-52, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19937046
8.
Concomitant activity of histamine and cysteinyl leukotrienes on porcine nasal mucosal vessels and nasal inflammation in the rat.
Pharmacology
; 85(5): 311-8, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20453555
9.
Alpha-2c-adrenergic receptors contribute to basal nasal patency in the anesthetized cat.
Pharmacology
; 85(5): 259-63, 2010.
Artigo
em Inglês
| MEDLINE | ID: mdl-20375536
10.
Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: part 2.
Bioorg Med Chem Lett
; 19(4): 1164-7, 2009 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19147350
11.
Structural determinants for histamine H(1) affinity, hERG affinity and QTc prolongation in a series of terfenadine analogs.
Bioorg Med Chem Lett
; 19(17): 5043-7, 2009 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19660947
12.
Identification of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2482-6, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19332374
13.
The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety.
Bioorg Med Chem Lett
; 19(9): 2519-23, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19339177
14.
Effect of a novel NOP receptor agonist (SCH 225288) on guinea pig irritant-evoked, feline mechanically induced and canine infectious tracheobronchitis cough.
Pharmacology
; 84(3): 153-61, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19696521
15.
Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.
J Med Chem
; 62(9): 4370-4382, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30986068
16.
Structure-activity relationships of 3-substituted N-benzhydryl-nortropane analogs as nociceptin receptor ligands for the treatment of cough.
Bioorg Med Chem Lett
; 18(24): 6340-3, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18990569
17.
Characterization of murine CEACAM1 in vivo reveals low expression on CD8+ T cells and no tumor growth modulating activity by anti-CEACAM1 mAb CC1.
Oncotarget
; 9(77): 34459-34470, 2018 Oct 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30349641
18.
Preclinical Experimental and Mathematical Approaches for Assessing Effective Doses of Inhaled Drugs, Using Mometasone to Support Human Dose Predictions.
J Aerosol Med Pulm Drug Deliv
; 29(4): 362-77, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26859446
19.
TRPV1 receptor: a target for the treatment of pain, cough, airway disease and urinary incontinence.
Drug News Perspect
; 18(3): 165-71, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15915217
20.
Effect of combined histamine H1 and H3 receptor blockade on cutaneous microvascular permeability elicited by compound 48/80.
Life Sci
; 76(16): 1787-94, 2005 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-15698856