Detalhe da pesquisa
1.
N-glycosylation is a potent regulator of prion protein neurotoxicity.
J Biol Chem
; 299(9): 105101, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37507020
2.
Evidence for aggregation-independent, PrPC-mediated Aß cellular internalization.
Proc Natl Acad Sci U S A
; 117(46): 28625-28631, 2020 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33139554
3.
Alzheimer's Drug PBT2 Interacts with the Amyloid ß 1-42 Peptide Differently than Other 8-Hydroxyquinoline Chelating Drugs.
Inorg Chem
; 61(37): 14626-14640, 2022 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36073854
4.
Membrane orientation and oligomerization of the melanocortin receptor accessory protein 2.
J Biol Chem
; 295(48): 16370-16379, 2020 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32943551
5.
Intrinsic toxicity of the cellular prion protein is regulated by its conserved central region.
FASEB J
; 34(6): 8734-8748, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32385908
6.
G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Nature
; 520(7545): 94-8, 2015 Apr 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25600267
7.
Production of Artificially Doubly Glycosylated, 15N Labeled Prion Protein for NMR Studies Using a pH-Scanning Volatile Buffer System.
J Org Chem
; 85(3): 1687-1690, 2020 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31692356
8.
Copper(II) Binding to PBT2 Differs from That of Other 8-Hydroxyquinoline Chelators: Implications for the Treatment of Neurodegenerative Protein Misfolding Diseases.
Inorg Chem
; 59(23): 17519-17534, 2020 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33226796
9.
Molecular Features of the Zn2+ Binding Site in the Prion Protein Probed by 113Cd NMR.
Biophys J
; 116(4): 610-620, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30678993
10.
X-ray Absorption Spectroscopy Investigations of Copper(II) Coordination in the Human Amyloid ß Peptide.
Inorg Chem
; 58(9): 6294-6311, 2019 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013069
11.
Correction: Human ß-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
PLoS Genet
; 12(1): e1005801, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26744891
12.
The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects.
J Biol Chem
; 292(18): 7651-7661, 2017 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28264929
13.
Human ß-Defensin 3 [corrected] Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid.
PLoS Genet
; 11(12): e1005673, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26646717
14.
Electrostatic Similarity Analysis of Human ß-Defensin Binding in the Melanocortin System.
Biophys J
; 109(9): 1946-58, 2015 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26536271
15.
A new paradigm for enzymatic control of α-cleavage and ß-cleavage of the prion protein.
J Biol Chem
; 289(2): 803-13, 2014 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24247244
16.
n-Dopants Based on Dimers of Benzimidazoline Radicals: Structures and Mechanism of Redox Reactions.
Chemistry
; 21(30): 10878-85, 2015 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26088609
17.
Targeting protein-trafficking pathways alters melanoma treatment sensitivity.
Proc Natl Acad Sci U S A
; 109(2): 553-8, 2012 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22203954
18.
Combined EXAFS and DFT structure calculations provide structural insights into the 1:1 multi-histidine complexes of Cu(II) , Cu(I) , and Zn(II) with the tandem octarepeats of the mammalian prion protein.
Chemistry
; 20(31): 9770-83, 2014 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25042361
19.
Adapter reagents for protein site specific dye labeling.
Biopolymers
; 102(3): 273-9, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24599728
20.
Copper-zinc cross-modulation in prion protein binding.
Eur Biophys J
; 43(12): 631-42, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25395329