Detalhe da pesquisa
1.
Glutamate 350 Plays an Essential Role in Conformational Gating of Long-Range Radical Transport in Escherichia coli Class Ia Ribonucleotide Reductase.
Biochemistry
; 56(6): 856-868, 2017 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28103007
2.
Generation of a stable, aminotyrosyl radical-induced α2ß2 complex of Escherichia coli class Ia ribonucleotide reductase.
Proc Natl Acad Sci U S A
; 110(10): 3835-40, 2013 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431160
3.
Reverse Electron Transfer Completes the Catalytic Cycle in a 2,3,5-Trifluorotyrosine-Substituted Ribonucleotide Reductase.
J Am Chem Soc
; 137(45): 14387-95, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26492582
4.
Reversible, long-range radical transfer in E. coli class Ia ribonucleotide reductase.
Acc Chem Res
; 46(11): 2524-35, 2013 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-23730940
5.
Redox-linked changes to the hydrogen-bonding network of ribonucleotide reductase ß2.
J Am Chem Soc
; 135(17): 6380-3, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23594029
6.
STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors.
Mol Cancer Ther
; 21(2): 282-293, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34815361
7.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475697
8.
Kinetics of radical intermediate formation and deoxynucleotide production in 3-aminotyrosine-substituted Escherichia coli ribonucleotide reductases.
J Am Chem Soc
; 133(24): 9430-40, 2011 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21612216
9.
Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase.
J Am Chem Soc
; 133(40): 15942-5, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21913683
10.
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
RSC Med Chem
; 12(7): 1164-1173, 2021 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34355182
11.
An orally available non-nucleotide STING agonist with antitumor activity.
Science
; 369(6506)2020 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32820094
12.
Use of 3-aminotyrosine to examine the pathway dependence of radical propagation in Escherichia coli ribonucleotide reductase.
Biochemistry
; 48(51): 12125-32, 2009 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19916558
13.
Structural examination of the transient 3-aminotyrosyl radical on the PCET pathway of E. coli ribonucleotide reductase by multifrequency EPR spectroscopy.
J Am Chem Soc
; 131(43): 15729-38, 2009 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-19821570
14.
Impacting Global Health Through Equipment Repurposing: Measurable Progress Through the Accumulation of Many Tiny Victories.
J Pharm Sci
; 107(3): 788-793, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074379
15.
Physicochemical and formulation developability assessment for therapeutic peptide delivery--a primer.
AAPS J
; 17(1): 144-55, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398427
16.
Unnatural amino acids: better than the real things?
F1000 Biol Rep
; 1: 88, 2009 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20948602
17.
Gold(I)-catalyzed regioselective cyclizations of silyl ketene amides and carbamates with alkynes.
J Org Chem
; 72(16): 6287-9, 2007 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-17625890
18.
Phosphate triester hydrolysis promoted by an N2S(thiolate)Zn complex: mechanistic implications for the metal-dependent reactivity of peptide deformylase.
Inorg Chem
; 44(21): 7559-69, 2005 Oct 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16212382